Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis

Rokni, Alex M; Ayasse, Marissa; Ahmed, Adnan; Guggina, Lauren; Kantor, Robert; Silverberg, Jonathan I.

doi:10.1007/s00403-022-02346-y

Cited by 9 publications

(7 citation statements)

References 53 publications

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“…Over the last decades, pulse therapy has become a safe option to treat pemphigus: it avoids the long-term side effects of oral daily treatment with corticosteroids and/or immunosuppressant drugs. 9 , 10 , 16 , 17 , 18 , 19 , 20 , 21 The main reported modalities of pulse therapy comprehend DCP and dexamethasone pulse with oral azathioprine, resulting in similar control of the disease, but a higher frequency of relapse in azathioprine regimen. 22 In Brazil, a unique report on pulse therapy for pemphigus was achieved from the literature.…”

Section: Discussionmentioning

confidence: 99%

“… 1 , 8 However, several morbidities associated with long-term daily corticosteroid use have been reported. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

“… 1 Nevertheless, in Brazil, Rituximab has been prescribed as an exceptional option, for those cases of unresponsiveness to commoner drugs, 12 , 13 , 14 which encouraged us to look for a diverse treatment in order to decrease corticoid side effects when chronically prescribed. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

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Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

Fontenelle

Filho

Vernal

et al. 2023

Anais Brasileiros de Dermatologia

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Section: Discussionmentioning

confidence: 99%

“… 1 , 8 However, several morbidities associated with long-term daily corticosteroid use have been reported. 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

Fontenelle

Filho

Vernal

et al. 2023

Anais Brasileiros de Dermatologia

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“…Prolonged systemic activation of these pathways could potentially contribute to an increased risk of CVD. Also, cases of irregular cardiac rhythm and AI myocarditis have been reported [114][115][116].…”

Section: Pemphigusmentioning

confidence: 99%

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Maranduca,

Cosovanu,

Clim

et al. 2023

Diagnostics

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Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the renin–angiotensin system (RAS) in the pathogenesis and progression of these conditions. RAS is a multicomponent cascade, primarily known for its role in regulating blood pressure and fluid balance. All of the RAS components play an important role in controlling inflammation and other immune responses. Angiotensin II, the main effector, acts on two essential receptors: Angiotensin Receptor 1 and 2 (AT1R and AT2R). A disturbance in the axis can lead to many pathological processes, including autoimmune (AI) diseases. AT1R activation triggers diverse signaling cascades involved in inflammation, fibrosis and tissue remodeling. Experimental studies have demonstrated the presence of AT1R in various cutaneous cells and immune cells, further emphasizing its potential contribution to the AI processes in the skin. Furthermore, recent investigations have highlighted the role of other RAS components, beyond angiotensin-converting enzyme (ACE) and Ang II, that may contribute to the pathophysiology of AIDD. Alternative pathways involving ACE2, Ang receptors and Ang-(1-7) have been implicated in regulating immune responses and tissue homeostasis within the skin microenvironment. Understanding the intricate involvement of the RAS in AIDD may provide novel therapeutic opportunities. Targeting specific components of the RAS, such as angiotensin receptor blockers (ARBs), ACE inhibitors (ACEIs) or alternative RAS pathway modulators, could potentially ameliorate inflammatory responses, reduce tissue damage and lessen disease manifestations. Further research is warranted to outline the exact mechanisms underlying RAS-mediated immune dysregulation in AIDD. This abstract aims to provide a concise overview of the intricate interplay between the RAS and AIDD. Therefore, we elaborate a systematic review of the potential challenge of RAS in the AIDD, including psoriasis, systemic sclerosis, vitiligo, lupus erythematosus and many more.

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“…O tratamento dos pênfigos tem por base a corticoterapia sistêmica, associada ou não a imunossupressores (LEE et al, 2021;, porém o uso crônico dos corticoides pode estar associado a graves comorbidades (AMBIEL, ROSELINO, 2014;ROKNI et al, 2022).…”

Section: Lista De Figurasunclassified

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Oliveira¹

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Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis

Cited by 9 publications

References 53 publications

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

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Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis

Cited by 9 publications

References 53 publications

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

Dexamethasone-cyclophosphamide pulse therapy outcomes comparing pemphigus vulgaris and pemphigus foliaceus groups in a Brazilian cohort study

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

Polimorfismos genéticos dos receptores da Fc&gamma; IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

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Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe