Association of B-chronic lymphocytic leukaemia and T-large granular lymphocyte leukaemia

T-Cell Large Granular Lymphocyte Leukemia and Related Disorders

“…Other researchers have described associations between LGL leukemia and CLL [58], marginal zone lymphoma [59], and Hodgkin's disease [60]. In most cases described in the literature, both lymphoproliferative disorders were diagnosed simultaneously.…”

Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 cases

“…Of these, 20 corresponded to the combination of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and peripheral T-cell lymphoma (PTCL) ( Table 1); in most instances, however, PTCL developed in patients already followed and possibly treated for B-CLL/SLL (Table 1). To the best of our knowledge, only 3 examples of simultaneous presentation of PTCL and B-CLL/SLL at the same anatomical site have been published since 1992 [4][5][6], 1 corresponding to contemporary occurrence of large granular lymphocyte leukemia (LGL) and B-CLL in the peripheral blood [6].…”

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

“…As such, our data suggest that there may be a distinction between a monoclonal lymphocytosis and leukemic clonal proliferations. Furthermore, the strong association of T-LGL with various B-cell dyscrasia 11,[35][36][37][38][39][40] also argues for a chronic immune process that can engage multiple arms of immunity or suggests some as yet undefined constitutional or acquired dysregulation within T cells that influences the entire lymphoid compartment.…”