Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study

Heshmati, Keyvan; Harris, David A.; Rosner, Bernard; Pranckevicius, Elisha; Ardestani, Ali; Cho, Nancy; Golshan, Mehra; Ng, Winnie; Ligibel, Jennifer A.; Tavakkoli, Ali; Sheu, Eric G.

doi:10.1007/s11695-018-03701-7

Cited by 15 publications

(11 citation statements)

References 27 publications

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“…Regarding breast cancer specifically, bariatric surgery reduced breast cancer risk among postmenopausal women compared to non-surgical controls, with the most significant impact on risk reduction in ER-negative tumors, with a 64% decrease in risk [ 120 , 134 , 140 ]. Moderate declines in ER-positive [ 141 ] and HER2-positive breast cancer rates were reported [ 142 ]. An additional benefit to bariatric surgery is that subsequent cancers appear less aggressive or detected earlier.…”

Section: Weight Loss and Breast Cancermentioning

confidence: 99%

The role of obesity and bariatric surgery-induced weight loss in breast cancer

Bohm

Sipe

Pye

et al. 2022

Cancer Metastasis Rev

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Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the USA. Breast cancer, in particular, is associated with obesity and is the focus of this review. The exact causal links between obesity and breast cancer remain unclear. Still, interactions have emerged between body mass index, tumor molecular subtype, genetic background, and environmental factors that strongly suggest obesity influences the risk and progression of certain breast cancers. Supportive preclinical research uses various diet-induced obesity models to demonstrate that weight loss, via dietary interventions or changes in energy expenditure, reduces the onset or progression of breast cancers. Ongoing and future studies are now aimed at elucidating the underpinning mechanisms behind weight-loss-driven observations to improve therapy and outcomes in patients with breast cancer and reduce risk. This review aims to summarize the rapidly emerging literature on obesity and weight loss strategies with a focused discussion of bariatric surgery in both clinical and preclinical studies detailing the complex interactions between metabolism, immune response, and immunotherapy in the setting of obesity and breast cancer.

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Section: Weight Loss and Breast Cancermentioning

confidence: 99%

The role of obesity and bariatric surgery-induced weight loss in breast cancer

Bohm

Sipe

Pye

et al. 2022

Cancer Metastasis Rev

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“…2,[30][31][32][33] Evidence from retrospective cohort studies found a reduced risk of breast cancer in female surgical patients with obesity. 11,34 Roux-en-Y gastric bypass (RYGB), a common type of bariatric surgery, was reported to be related with decreased risk of cancer mortality. 7 However, no such findings were detected in the current analysis, as the risks of obesity-related cancer, breast and genital cancers, and cancer mortality were not significantly different between the bariatric surgery group and matched control group.…”

Section: Discussionmentioning

confidence: 99%

Association between bariatric surgery and risks of cancer among Chinese patients with type 2 diabetes mellitus: A retrospective cohort study

Wei

Wong

et al. 2021

Journal of Diabetes

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“…In multiple studies, this effect has been statistically significant only in women. Of note, one of the most common cancers observed in these studies was breast cancer, and bariatric surgery has been associated with reduced breast cancer risk in several studies (17,21,(97)(98)(99)(100)(101)(102).…”

Section: Bariatri C Surg Ery and B Re A S T C An Cer Ris Kmentioning

confidence: 93%

Obesity and breast cancer: Preventive and therapeutic possibilities for bariatric surgery

Crafts

Tonneson

Wolfe

et al. 2022

Obesity

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Breast cancer is the most common and second deadliest malignancy in women. With rising obesity rates and building evidence for a strong association with obesity, the incidence of breast cancer can be expected to increase. Weight loss reduces breast cancer risk, the mechanisms of which are still poorly understood. As an effective therapy for obesity, bariatric surgery may be a powerful tool in breast cancer prevention and treatment. This review details the potential physiologic mechanisms that may underlie this association, as well as recently published studies that reinforce the link between bariatric surgery and a reduction in incident breast cancer. The use of bariatric surgery as an adjunct therapy in endometrial cancer also raises the potential for similar use in select breast cancer patients. Despite the expanding potential applications of bariatric surgery in this field, publications to date have been strictly observational, highlighting a need for future clinical trials.

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Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study

Cited by 15 publications

References 27 publications

The role of obesity and bariatric surgery-induced weight loss in breast cancer

The role of obesity and bariatric surgery-induced weight loss in breast cancer

Association between bariatric surgery and risks of cancer among Chinese patients with type 2 diabetes mellitus: A retrospective cohort study

Obesity and breast cancer: Preventive and therapeutic possibilities for bariatric surgery

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