Association of baseline and changes in adiponectin, homocysteine, high-sensitivity C-reactive protein, interleukin-6, and interleukin-10 levels and metabolic syndrome incidence: Tehran lipid and glucose study

Zahedi, Asiyeh Sadat; Daneshpour, Maryam Sadat; Akbarzadeh, Mahdi; Hedayati, Mehdi; Azizi, Fereidoun; Zarkesh, Maryam

doi:10.1016/j.heliyon.2023.e19911

Cited by 10 publications

(7 citation statements)

References 89 publications

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“…The gold standard measurement method for visceral fat is CT. However, previous studies on MetS prediction have been conducted without obtaining data on visceral fat [11,12,13,14,15,16,17,18,19,20,21,22] because of the time-consuming and invasive process. We built a device that measures visceral fat non-invasively and constructed human dataset that includes VFA between 2015-2020.…”

Section: Discussionmentioning

confidence: 99%

“…We built an algorithm for predicting MetS onset using visceral fat. There are multiple algorithms available worldwide for predicting MetS onset [11,12,13,14,15,16,17,18,19,20,21,22]. One challenge in predicting MetS onset is that the diagnostic de nition of MetS differs in each country.…”

Section: Discussionmentioning

confidence: 99%

“…4). There have previously been many onset prediction algorithms that use blood items [12,13,14,15,16,17,18,19,20,21,22]. The visceral fat meter developed in this study is a non-invasive device.…”

Section: Discussionmentioning

confidence: 99%

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Effect of visceral fat on onset of metabolic syndrome

Bushita,

Ozato,

Mori

et al. 2024

Preprint

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Background Metabolic syndrome (MetS) increases the risk of cardiovascular and lifestyle-related diseases. Therefore, early detection is important to prevent MetS. This study analysed the effects of visceral fat on MetS using health examination. A MetS onset prediction algorithm was developed. Methods Health examination data were obtained from the Iwaki Health Promotion Project conducted in Aomori Prefecture in Japan, wherein labels indicated the development of MetS within the three years (213 onset and 1320 non-onset cases). The data were divided into training and test data (8:2 ratio), and 18 onset prediction models were developed to support the SHapley Additive exPlanations (SHAP) value. The onset labels and non-invasive input data were used as the output and input variables, respectively. We selected the model with the highest area under the curve (AUC) score when conducting five-fold cross validation, and the AUC of the test data was calculated. Feature impact was calculated based on SHAP. Results There were 169 and 1058 people in the metabolic and non-metabolic syndrome groups, respectively. The visceral fat area was significantly higher in the onset group than in the non-onset group (p < 0.00001). The cut-off value based on the receiver operating characteristic curve was 82 cm2, and the AUC was 0.86. Machine learning was employed on six items reported to contribute to the onset of MetS in addition to visceral fat to build an onset prediction algorithm. The cross-validation AUC = 0.90 and test AUC = 0.88 indicated a high-accuracy algorithm. The visceral fat was found to be the main factor, as confirmed by conventional feature importance in machine learning. Conclusions Visceral fat is crucial to determining the onset of MetS in the future. A high-accuracy onset prediction algorithm was developed based on non-invasive parameters, including visceral fat.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of visceral fat on onset of metabolic syndrome

Bushita,

Ozato,

Mori

et al. 2024

Preprint

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“…Low IL-10 levels are associated with metabolic syndrome, and obesity is correlated with increased levels of this cytokine [ 15 , 16 ]. In a longitudinal study of Iranian adults, a decrease in IL-10 levels was observed in participants with persistent metabolic syndrome [ 40 ]. Patients with metabolic syndrome have a distinct inflammatory pattern, as the syndrome affects the expression of proinflammatory genes in adipose tissue and the circulating cytokine levels [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics

Freitas,

de Souza Silva,

Ferreira Fratelli

et al. 2024

Nutrients

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Populational aging is marked by chronic noncommunicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1β are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants’ IL-10 and IL-1β serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants’ genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient’s T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarly, IL-1β levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.

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“…Водночас підвищення рівня АТ інгібується протизапальним інтерлейкіном-10 (ІЛ-10) [8]. При ожирінні рівень ІЛ-10 знижується, що асоціюється з розвитком інсулінорезистентності [9][10][11], порушенням репродуктивної функції у жінок [12] та ризиком розвитку серцево-судинних подій [13][14][15]. При ожирінні ступінь імунного запалення прямо корелює з метаболічними порушеннями [16,17].…”

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Myocardial Remodeling Markers in Hypertensive and Overweight or Obese Patients

Potaskalova,

Khaitovych,

Natrus

et al. 2023

FMEP

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Pro-inflammatory and anti-inflammatory cytokines can be used as markers of the severity of the arterial hypertension (AH) and the risk of its complications. The objective: to analyze the significance of interleukin-10 (IL-10) and interleukin-1β (IL-1β) as markers of myocardial remodeling in patients with arterial hypertension (AH) and overweight or obesity. Materials and methods. 103 patients with AH (60 women and 43 men) took part in the study. The average age of the participants was 53.21±8.5 years, the average duration of AH – 8.2±6.3 years. The patients were divided into two groups according to the level of IL-10. The first group included 80 (78%) patients with AH and body mass index (BMI) ≥25 kg/m2 who had a normal level of IL-10 (up to 32 pg/ml), the second group included 23 (22%) individuals with increased anti-inflammatory cytokine. Also, the patients were divided into two groups according to cytokine levels. The first group included 74 (72%) patients with AH and overweight or obesity (the level of IL-1β was up to 11 pg/ml), the second group included 29 (28%) patients with an elevated level of IL-1β. All subjects underwent an anthropometric measurement, clinical and laboratory examination, and determination of the level of anti-inflammatory cytokine IL-10 and pro-inflammatory cytokine IL-1β by enzyme immunoassay method. Results. The results of pro-inflammatory and anti-inflammatory cytokine concentrations (IL-1β and IL-10, respectively) were different. It was found that the level of IL-10 does not depend on the age of patients and the duration of AH, but there is a direct relationship between the level of the anti-inflammatory cytokine and BMI (35.8±5.7 kg/m2 vs. 32.4±5.7 kg/m2; p<0.05) with fasting glycemia level (r=0.3; p<0.05). It is also indicated that patients AH and increased BMI have on average a significantly longer QT interval (0.40±0.07 s vs. 0.36±0.04 s; p<0.05). It was determined that 13% of patients with elevated anti-inflammatory cytokine levels had QT prolongation. In 39% of cases, an increase in the mass index of the myocardium of the left ventricle was found (twice more among women). A direct correlation between the level of homocysteine and pro-inflammatory (r=0.31; p<0.05) and anti-inflammatory cytokines (r=0.47; p<0.05) was determined. At the same time, patients with elevated levels of IL-1β had a direct correlation with left ventricular myocardial mass index (r=0.42; p<0.05) and average daily mean arterial pressure (r=0.85; p<0.005). Conclusions. The anti-inflammatory cytokine IL-10 has greater prognostic significance than the pro-inflammatory cytokine IL-1β. An increased level of IL-10 in patients with AH and BMI ≥25 kg/m2 may indicate an adaptive reaction of the organism’s immune response. A high level of IL-10 in this cohort of patients is associated with worse control of blood pressure levels and can be considered as a predictor of the development of cardiac arrhythmias.

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Association of baseline and changes in adiponectin, homocysteine, high-sensitivity C-reactive protein, interleukin-6, and interleukin-10 levels and metabolic syndrome incidence: Tehran lipid and glucose study

Cited by 10 publications

References 89 publications

Effect of visceral fat on onset of metabolic syndrome

Effect of visceral fat on onset of metabolic syndrome

IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults’ Clinical Characteristics

Myocardial Remodeling Markers in Hypertensive and Overweight or Obese Patients

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