2015
DOI: 10.1097/psy.0000000000000231
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Association of Baseline Sleep Quality With Trajectories of Depressive Symptoms in Patients Undergoing Interferon Treatment

Abstract: Objective Some patients with hepatitis C (HCV) starting interferon-α (IFN-α) experience depression, although many patients do not develop depressive symptoms. We have found that poor sleep is associated with increased depressive symptoms on average. It is unknown whether this association holds generally or is driven by a specific, distinct subgroup. This investigation first determined whether patterns of change in depressive symptoms form clinically meaningful, distinct sub-groups; and then tested the extent t… Show more

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Cited by 3 publications
(2 citation statements)
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References 97 publications
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“…Another limitation is that each WOMAC pain development pattern is relatively steady over time, where participants' pain scores were primarily determined by their baseline levels. Although this is consistent with the findings of the previous study of pain trajectory and with other trajectory studies, such as those on depression and gait speed , this scenario could be due to the so‐called horseracing effect, in which a prolonged condition that has been ongoing before the baseline observation would in general maintain its baseline level over time, unless the important risk factors under investigation, such as dietary intake for WOMAC pain, also change substantially during the study period. But, as mentioned, dietary fiber intake changes little over time; thus, such a stable exposure limits our ability to examine the association between modified dietary fiber intake and WOMAC knee pain patterns over time.…”
Section: Discussionsupporting
confidence: 90%
“…Another limitation is that each WOMAC pain development pattern is relatively steady over time, where participants' pain scores were primarily determined by their baseline levels. Although this is consistent with the findings of the previous study of pain trajectory and with other trajectory studies, such as those on depression and gait speed , this scenario could be due to the so‐called horseracing effect, in which a prolonged condition that has been ongoing before the baseline observation would in general maintain its baseline level over time, unless the important risk factors under investigation, such as dietary intake for WOMAC pain, also change substantially during the study period. But, as mentioned, dietary fiber intake changes little over time; thus, such a stable exposure limits our ability to examine the association between modified dietary fiber intake and WOMAC knee pain patterns over time.…”
Section: Discussionsupporting
confidence: 90%
“…With a relatively short period of time and few strong time-varying risk factors for WOMAC pain change in our study, we expect that each WOMAC pain trajectory is relatively steady over time. The WOMAC patterns are similar to other trajectories defined by group-based modeling for depression (6) and gait speed (7). This phenomenon is further supported by Figure below, in which WOMAC pain patterns starting at baseline are materially the same as started from the 12-month exam (1).…”
Section: Dear Editorsupporting
confidence: 63%