Association of Behçet’s disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis

Chen, Tingqiao; Shao, Xinyi; Li, Hao; Chen, Yangmei; Liu, Lin; Zhong, Judan; Chen, Jin

doi:10.1007/s10238-023-01044-x

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Some studies have shown that patients with BD are more likely to have metabolic syndrome (MetS), which is reported to be present in 25.52% of patients [ 110 ]. Consistent with previous reports, a study by Chen et al confirmed an important association between BD and MetS: the risk of metabolic syndrome was 126% greater in the BD group than in the healthy control group [ 111 ]. These findings revealed that BD is significantly associated with insulin resistance, diabetes mellitus, and hypertension [ 111 ].…”

Section: Obesity and Eye Diseasessupporting

confidence: 89%

Obesity, body fat distribution and eye diseases

Bosello,

Vanzo,

Zaffalon

et al. 2024

Eat Weight Disord

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Background The prevalence of obesity, a chronic disease, is increasing, and obesity is now considered a global epidemic. Eye diseases are also increasing worldwide and have serious repercussions on quality of life as well as increasingly high costs for the community. The relationships between obesity and ocular pathologies are not yet well clarified and are not pathologically homogeneous: they seem to be somehow linked to excess body fat, especially to the distribution of adipose tissue and its ectopic deposits. Purpose Our objective was to examine the associations between obesity and anthropometric indices, including body mass index (BMI), waist circumference (WC), and the waist/hip ratio (WHR), and the risk of most widespread eye diseases, with particular attention given to the most significant metabolic mechanisms. Methods This article provides a narrative overview of the effect of obesity and anthropometric measurements of body fat on prevalent eye diseases. We used the MEDLINE/PubMed, CINAHL, EMBASE, and Cochrane Library databases from 1984 to 2024. In addition, we hand-searched references from the retrieved articles and explored a number of related websites. A total of 153 publications were considered. Results There is significant evidence that obesity is associated with several eye diseases. Waist circumference (WC) and the waist/hip ratio (WHR) have been observed to have stronger positive associations with eye diseases than BMI. Conclusions Obesity must be considered a significant risk factor for eye diseases; hence, a multidisciplinary and multidimensional approach to treating obesity, which also affects ocular health, is important. In the prevention and treatment of eye diseases related to obesity, lifestyle factors, especially diet and physical activity, as well as weight changes, both weight loss and weight gain, should not be overlooked. Level of evidence Level V narrative review.

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Section: Obesity and Eye Diseasessupporting

confidence: 89%

Obesity, body fat distribution and eye diseases

Bosello,

Vanzo,

Zaffalon

et al. 2024

Eat Weight Disord

View full text Add to dashboard Cite

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Diabetes mellitus in rheumatic diseases: clinical characteristics and treatment considerations

Fedorchenko,

Mahmudov,

Abenov

et al. 2023

Rheumatol Int

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Postoperative complications in patients with Behçet’s disease

Jung,

Park,

Kim

et al. 2024

Clin Rheumatol

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Objective To assess the proportion of postoperative complications of various surgeries in patients with Behçet’s disease (BD) and compare the risk of surgical complications between BD patients and controls. Methods We analyzed 389 BD patients who underwent surgeries at Seoul National University Hospital between January 2003 and December 2019. Controls were 1:1 matched with BD patients based on age at surgery, sex, and type of surgery. Generalized estimating equation analyses were performed to compare the postoperative complications between BD patients and controls. Results Among 632 surgeries in BD patients, 36 (5.7%) surgical site complications, including wound dehiscence (38.9%), bleeding (13.9%), infections (8.3%), anastomotic dehiscence (22.2%), and stricture (5.6%), occurred after median 12 days (IQR 7.8–22.0). Surgical site complications developed frequently after cardiac (33.3%) and vascular (22.2%) surgeries and rarely occurred after ophthalmic (1.5%) surgeries. Seventeen (2.7%) cases required reoperation within median 15 days (IQR 7.0–43.0). Four patients died within median 21 days (IQR 8.3–41.3 days). After adjustment for confounders, BD patients exhibited a significantly higher risk of surgical site complications (OR 3.4, 95% CI 1.4–8.0) and reoperation (OR 5.2, 95% CI 1.2–22.8) after cardiovascular surgery than controls. However, the risks of surgical site complications and reoperation after other types of surgery were similar in both groups. Conclusions The risk of postoperative complications varies according to the type of surgeries among BD patients. While cardiovascular surgeries result in higher perioperative complications in BD patients, ophthalmic surgeries show a safety profile similar to those in non-BD patients. Key Points• Patients with Behçet’s disease exhibited an increased risk of surgical site complications and subsequent reoperations after cardiovascular surgery than controls.• The safety profile of ophthalmic surgery was comparable between patients with Behçet’s disease and controls.• In patients with Behçet’s disease, the risk of postoperative complications varies according to the type of surgery.

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Association of Behçet’s disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis

Cited by 5 publications

References 48 publications

Obesity, body fat distribution and eye diseases

Obesity, body fat distribution and eye diseases

Diabetes mellitus in rheumatic diseases: clinical characteristics and treatment considerations

Postoperative complications in patients with Behçet’s disease

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