Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York

Geer, Laura A.; Pycke, Benny F. G.; Waxenbaum, Joshua; Sherer, David M.; Abulafia, Ovadia; Halden, Rolf U.

doi:10.1016/j.jhazmat.2016.03.028

Cited by 169 publications

(98 citation statements)

References 36 publications

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“…For example, the significant association between prenatal TCS and head circumference in the Lassen et al (2016) study was observed in boys, but not girls; the two other studies limited to boys (Philippat et al , 2014 reported null results, as did the two studies that examined boys and girls together Geer et al 2017).…”

Section: Birth Outcomesmentioning

confidence: 85%

“…Tier 2 included 13 publications. Twelve of those publications (Wolff et al , 2010(Wolff et al , 2015Philippat et al 2012Philippat et al , 2014Watkins et al 2015;Aker et al 2016;Ashley-Martin et al 2016;Buckley et al 2016;Lassen et al 2016;Smarr et al 2017;Geer et al 2017) were based on seven different cohorts assembled in France, Puerto Rico, Denmark, Canada, and various parts of the US. One paper ) presented a case-control study that used incident cases identified among members of a French cohort.…”

Section: Methodsmentioning

confidence: 99%

“…Of the 43 studies, 24 were conducted in North America (Wolff et al , 2010(Wolff et al , 2015Clayton et al 2011;You et al 2011;Buttke et al 2012;Savage et al 2012Savage et al , 2014Koeppe et al 2013;Lankester et al 2013;Buser et al 2014;Spanier et al 2014;Adgent and Rogan 2015;Li et al 2015;Ihde et al 2015;Shiue 2015aShiue , 2015bVelez et al 2015;Ashley-Martin et al 2016;Buckley et al 2016;Poole et al 2016;Scinicariello and Buser 2016;Smarr et al 2017;Geer et al 2017), two studies in the Caribbean (Watkins et al 2015;Aker et al 2016), 10 studies in Europe (Allmyr et al 2009;Chevrier et al 2012;Philippat et al 2012Philippat et al , 2014Bertelsen et al 2013;Buhl et al 2014;Den Hond et al 2013, 2015Geens et al 2015;Lassen et al 2016), four in Asia (Chen et al 2013;Wang et al 2015;Xue et al 2015;Zhu et al 2016), and three in Australia (Cullinan et al 2012(Cullinan et al , 2015a…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…Similarly, Geer et al (2017) analyzed third trimester urine samples and cord blood samples separately and was assigned to Tier 2. The remaining five publications were assigned to Tier 1.…”

Section: Exposure Assessmentmentioning

confidence: 99%

“…For example, Wolff et al (2008) and Geer et al (2017) reported the associations between prenatal TCS and birth weight in boys and girls adjusted for sex, Philippat et al (2012) and Philippat et al (2014) excluded girls from their analyses, and Lassen et al (2016) reported findings separately for boys and girls.…”

Section: Birth Outcomesmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

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Section: Birth Outcomesmentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Overview Of Studiesmentioning

confidence: 99%

“…Similarly, Geer et al (2017) analyzed third trimester urine samples and cord blood samples separately and was assigned to Tier 2. The remaining five publications were assigned to Tier 1.…”

Section: Exposure Assessmentmentioning

confidence: 99%

Section: Birth Outcomesmentioning

confidence: 99%

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Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

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Triclosan treatment to pregnant albino rats affects offspring numbers and the liver of both the pregnant rats and their offspring, and these effects are ameliorated by co‐treatment with bee honey

Hanafy

Abo-Ouf

Mohamed

et al. 2020

The Anatomical Record

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We have assessed the effects of the broad‐spectrum bactericide triclosan on the liver of pregnant albino rats and their offspring, and evaluated the protective potential of bee honey, which has radical‐scavenging properties. The study involved treatment of 72 pregnant rats followed by examination of the pregnant rats and their offspring. The pregnant rats were divided equally into six groups (I–VI), each of which was subdivided equally into two Subgroups (A and B). Rats in the A subgroups were gavaged with a daily dose of 1.26 ml distilled water (IA), 1 ml corn oil (IIA), 1.68 ml aqueous solution of Clover Blossom honey (IIIA), 0.3 mg triclosan (IVA), 13 mg triclosan (VA), or 1.68 ml aqueous solution of honey with 13 mg triclosan (VIA), throughout pregnancy. Rats in the B subgroups received the same treatments throughout pregnancy and for 14 days after delivery. At the end of the experiments, the offspring's numbers were recorded and blood samples were taken from the pregnant rats for analysis. The livers of the studied groups were subjected for; histological study, morphometric analysis, and biochemical estimation of markers of oxidative stress. The results showed that the acceptable daily intake of triclosan did not induce significant pathological changes in the liver while high dose of triclosan induced pathological changes in the livers and reduced the numbers of offspring. Co‐administration of honey with triclosan ameliorated most pathological change. Therefore, decrease the exposure of the pregnant women to triclosan is encouraged or co‐supplementation with bee honey if exposure could not be avoided.

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Dietary Habits and Personal Care Product Use as Predictors of Urinary Concentrations of Parabens in Iranian Adolescents

Hajizadeh

Feizabadi

Feizi

2020

Environmental Toxicology and Chemistry

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Despite the widespread use of parabens as antimicrobial preservatives in personal care products (PCPs) and foodstuffs, recent studies show that exposure to parabens could result in endocrine disruption. The urinary methylparaben, ethylparaben, propylparaben, and butylparaben among 100 adolescents and their relationships with using 19 personal care and 18 food products were evaluated. Urinary paraben concentrations were significantly higher in the high-user group (8-19 products) compared to both low (0-3 products) and middle (4-7 products) user groups. The frequency of PCP use was associated with higher urinary levels of 4 parabens, and the frequency of food product use was associated with higher urinary methylparaben and ethylparaben. The use of mouthwash was associated with higher levels of methylparaben, ethylparaben, and propylparaben. Users of makeup base had higher methylparaben and propylparaben, users of eye makeup had higher propylparaben, and users of body wash, sunscreen, and lotion had higher urinary propylparaben than nonusers. Consumers of dairy products had significantly higher urinary methylparaben, propylparaben, and butylparaben, and cookie consumers had higher urinary methylparaben and ethylparaben, than nonusers. Consumers of canned foods and chips/snacks had higher methylparaben, and consumers of sauces and jams had higher ethylparaben than nonconsumers. The findings show that certain types of foods and personal care products could be important sources of paraben exposure.

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Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York

Cited by 169 publications

References 36 publications

Systematic review of the literature on triclosan and health outcomes in humans

Systematic review of the literature on triclosan and health outcomes in humans

Triclosan treatment to pregnant albino rats affects offspring numbers and the liver of both the pregnant rats and their offspring, and these effects are ameliorated by co‐treatment with bee honey

Dietary Habits and Personal Care Product Use as Predictors of Urinary Concentrations of Parabens in Iranian Adolescents

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