Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Lee, Hsin-Fu; Lin, Yun-Hsuan; Lin, Chia‐Pin; Wang, Chunli; Chang, Chi-Jen; Hsu, Lung‐An

doi:10.2169/internalmedicine.51.7173

Cited by 32 publications

(35 citation statements)

References 33 publications

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“…In addition, Framingham study revealed a higher incidence of ischemic heart disease in phenotype A (34). Similarly, Lee et al (35) suggest that blood group A is an independent risk factor for coronary artery disease and myocardial infarction in Taiwanese men younger than 45 years and women younger than 55 years. He et al (36) found that blood group B was an independent risk factor for myocardial infarction.…”

Section: Discussionmentioning

confidence: 89%

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Kaya¹,

Tanboğa²,

Kurt³

et al. 2013

Anadolu Kardiyol Derg

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Objective: We aimed to investigate the relationship between ABO blood groups and complexity of coronary lesions assessed by SYNTAX score (SS) in stable coronary artery disease (CAD) patients. Methods: Our cross-sectional and observational study population consisted of 559 stable CAD patients. From all patients, ABO blood group was determined and the SS was calculated as low SYNTAX score (0-22), intermediate SYNTAX (23-32) score and high SYNTAX score (>32). Statistical analysis was performed using Student's t-test or Mann-Whitney U test, ANOVA, or Kruskal-Wallis test and chi-square test. Multiple logistic regression analysis was used to identify the independent predictors of high SS. Results: The analysis between the SS tertiles revealed that the frequency of non-O blood group was significantly higher in the upper SS tertiles (56.2% vs. 75.9 vs. 80.2%, p<0.05). However, the frequencies of Rh types were similar in all tertiles. Multiple logistic regression analysis was applied for determining the predictors of high SS. Accordingly, non-O blood group (OR: 2.68, 95% CI 1.65-4.35, p<0.001), LV-EF (OR: 0.93, 95% CI 0.91-0.95, p<0.001), LDL(OR: 0.98, p<0.001), and e-GFR (OR: 0.99, 95% CI 0.98-0.98, p<0.001) were found to be the independent predictors of high SS. Conclusion: We showed that there were significant associations between ABO blood groups and complexity of angiographic CAD.

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Section: Discussionmentioning

confidence: 89%

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Kaya¹,

Tanboğa²,

Kurt³

et al. 2013

Anadolu Kardiyol Derg

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show abstract

“…Considerable evidence underpins CVDs to be linked with ABO blood group system [3,4,23,45] although the mechanism linking ABO blood group with CVD, particularly atherosclerosis, remains unclear. However, previous studies suggest that ABH antigen act as the principal agent for endothelial cell proliferation [3], as such plays a role in the disease process by a modulation in the vascular endothelial haemostasis [1,30]. Besides, the theory that glycosyltransferases (enzymes involved in the modification of the A, B and H antigens) regulate circulation of soluble products of cellular adhesion molecules (CAMs)biomarkers of inflammation-related diseasesmay explain the relationship [4,31].…”

Section: Introductionmentioning

confidence: 99%

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

Ureme

Anioke

Igboerika

2018

AJRB

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Objective: The study investigated the possibility of using blood groups as predictive indices for diseases associated with lipid metabolism. Methods: Lipid profiles were examined in 100 apparently healthy male (40) and female (60) subjects of different ABO blood groups aged between 18-30 years from Imo State University. Of these, 20 were blood group A, 30 were B blood type, 4 were AB blood type, and 46 were blood group O. Lipid profile parameters were determined according to enzymatic assay using a commercial kit from Randox Laboratories, United Kingdom and calculation using Friedewald’s equation. Monoclonal ABO blood grouping reagent by CLAS Technology, United Kingdom was used to determine the blood group. Results: Total Cholesterol (140.62 ± 21.66 mg/dl) and High-Density Lipoprotein (HDL) (96.20 ± 40.32 mg/dl) were highest in blood group B. Blood group A had the highest level of Triglyceride (80.84 ± 18.60 mg/dl) and Very Low-Density Lipoprotein (VLDL) (15.21 ± 6.24 mg/dl). Blood group O showed TC level of 130.60 ±34.76 mg/dl with the highest level of LDL (70.74 ± 20.15 mg/dl) and the lowest level of HDL (51.68 ± 20.50 mg/dl) compared to non- O blood types (P < 0.05). Conclusion: The study revealed that blood group O might have a higher propensity for dyslipidemia, suggesting an increased risk for disease associated with lipid metabolism.

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“…An association was found between blood type A and SCF. Recently, several studies examined the relationship between ABO blood types and coronary artery disease, and showed that non-A blood groups were associated with CAD (12,13). The present study is the first study to examine the association between SCF and ABO blood types.…”

Section: Discussionmentioning

confidence: 61%

Is there any association between ABO blood types and slow coronary flow?

Kaya¹

2019

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

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Aim: Slow coronary flow (SCF) is defined as a microvascular disorder characterized by slow advance of the contrast material administered during angiography, despite absence of epicardial coronary artery occlusion and delayed opacification of distal vascular structures. Genetically inherited ABO blood types are presumed to play role in coronary artery disease. In this study, the relationship between SCF and ABO blood types was investigated. Methods: The study was designed as a retrospective study, and included 250 cases that underwent coronary angiography procedure in our center between 2016 January and 2018 December (one hundred and twenty five cases of SCF and 125 cases of normal coronary angiogram). ABO blood types were determined using standard agglutination techniques in both study groups. Blood types were compared between both subject groups. Results: The frequency of blood type A was increased among patients with SCF in comparison with control subjects (p<0.001). High density lipoprotein cholesterol was increased in SCF group (p<0.001). Triglyceride, , total cholesterol and low density lipoprotein cholesterol levels were increased in the SCF group when compared to controls (p=0.003, p<0.001, and p<0.001, respectively). Conclusion: This study demonstrated that blood group A may be an increased risk for SCF.

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Association of Blood Group A with Coronary Artery Disease in Young Adults in Taiwan

Cited by 32 publications

References 33 publications

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease: an observational study

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

Is there any association between ABO blood types and slow coronary flow?

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