Association of blood mercury levels with bone mineral density in adolescents aged 12–19

Xu, Ke; Gao, Bingqian; Liu, Tingfeng; Li, Jiayi; Xiang, Yixin; Fu, Yicheng; Zhao, Mingyi

doi:10.1007/s11356-023-25701-6

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…A study on adolescents aged 12-19 found that blood mercury levels were signi cantly related to bone density in adolescents. Inverse correlation (Xu et al, 2023), consistent with another study based on the US NHANES database, there is a negative correlation between blood mercury levels and spinal bone density in adults, with low blood mercury levels (< 3 ug/L) having increased osteoporosis risk (Tang et al, 2022).…”

Section: Discussionsupporting

confidence: 86%

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

zhang,

Chen,

et al. 2023

Preprint

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Osteoporosis is emerging as a growing public health concern worldwide due to the aging population, and metal exposure is widely recognized as a risk factor for human health. However, studies on the relationship between metal exposure and bone health yield inconsistent results. Limited epidemiological research exists on the associations of metal mixtures with osteopenia and osteoporosis, particularly among ethnic minorities in China. We conducted a study on 9206 ethnic Chinese (Dong and Miao) aged 30–79 years using data from the Chinese Multi-Ethnic Cohort Study (CMCS) baseline survey database. We utilized inductively coupled plasma mass spectrometry (ICP-MS) to measure the concentrations of 11 metals in urine and quantitative ultrasound to measure bone mineral density (BMD). Multivariate logistic regression model, Quantile g-computation and Principal component analysis were used to explore the correlation between single-metal exposure and metal mixture exposure with osteopenia and osteoporosis. In the single-metal exposure model, urinary concentrations of As, Cd, Cr, Fe, Hg and Mn were positively associated with the risk of osteopenia. Conversely, urinary Co and Zn were negatively associated with the risk of osteopenia. Urinary As, Cd, Cr and Mn were positively associated with the risk of osteoporosis, while urinary V was negatively associated with the risk of osteoporosis. In addition, Quantile g-comptation showed that exposure to metal mixtures was positively associated with osteopenia and osteoporosis. Principal component analysis identified principal component 1, characterized by Fe and Mn, and principal component 3, characterized by Hg and Cd, as positively associated with osteopenia and osteoporosis. These findings suggest that the co-exposure of polymetals affects the occurrence and development of osteoporosis, warranting further investigation into the complex mechanisms involved.

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Section: Discussionsupporting

confidence: 86%

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

zhang,

Chen,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…All covariates included and adjusted in this study were collected based on prior literature [25][26][27][28][29], including age, gender, race, poverty income ratio, body mass index (BMI), physical activity, total calcium, phosphorus, total protein, and total cholesterol. BMI was calculated as measured weight (kg) divided by the square of height (m 2 ) and divided into underweight, normal, overweight, and obese according to the Centers for Disease Control and Prevention's sex-specific 2000 BMI-for-age growth charts for the United States [30].…”

Section: Covariatesmentioning

confidence: 99%

The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States

Liu,

Bao,

Liu

et al. 2024

Nutrients

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Bone mineral density (BMD) is a key parameter widely used in the assessment of bone health. Although many investigations have explored the relationship between trace elements and BMD, there are fewer studies focused on serum copper and BMD, especially for adolescents. Using data extracted from the National Health and Nutrition Examination Survey, we applied a multiple-linear regression and smooth curve fitting to assess the relationship between serum copper and BMD. A total of 910 participants were finally included in this study. After adjusting for relevant covariates, serum copper was negatively associated with lumbar spine BMD (β = −0.057, 95% CI: −0.109 to −0.005), trunk bone BMD (β = −0.068, 95% CI: −0.110 to −0.026), pelvis BMD (β = −0.085, 95% CI: −0.145 to −0.024), subtotal BMD (β = −0.072, 95% CI: −0.111 to −0.033), and total BMD (β = −0.051, 95% CI: −0.087 to −0.016) (p < 0.05). In quartile analysis, the highest level of serum copper was associated with decreased BMD when compared with those at the lowest quartile (p < 0.05). The stratified analysis revealed a significant interaction between age and the effects of serum copper on trunk bone BMD (p = 0.022) and pelvis BMD (p = 0.018). Meanwhile, the higher level of serum copper was negatively associated with BMD in males, and gender modified the relationship (p < 0.001). Future longitudinal studies will be necessary for a more definitive interpretation of our results.

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Rare earth element-modified MOF materials: synthesis and photocatalytic applications in environmental remediation

Le,

Jin,

Han

et al. 2024

Rare Met.

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Association of blood mercury levels with bone mineral density in adolescents aged 12–19

Cited by 3 publications

References 27 publications

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

Metal mixture exposure and the risk of osteopenia or osteoporosis: Baseline Data from the Chinese Multi-Ethnic Cohort (CMEC) Study

The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States

Rare earth element-modified MOF materials: synthesis and photocatalytic applications in environmental remediation

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