Association of blood pressure level with nonalcoholic fatty liver disease in nonhypertensive population

Abstract

The functional crosstalk between nonalcoholic fatty liver disease (NAFLD) and hypertension has been reported by some literatures; however, in nonhypertensive individuals, there is no article describes the characteristic of NAFLD. In this study, we aimed to determine the strength of the association between NAFLD with normal blood pressure (BP) in nonhypertensive individuals. This cross-sectional study was conducted in the sixth Affiliated Hospital of Wenzhou Medical University, from October 2007 to December 2011. In brief, 24,200 subjects were enrolled to participate in the survey. Among those subjects, there were 5305 enrolled subjects, those with filling the diagnostic criteria for NAFLD (21.9%; 4803 males and 502 females). Nonhypertension was identified in 17,403 (71.9%; 8179 males and 9224 females). The PR% of NAFLD for the systolic blood pressure (SBP) in quartiles 1 to 4 was 10.83, 12.55, 20.38, and 19.97. SBP, diastolic blood pressure (DBP), sex, age, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, fasting plasma glucose, uric acid, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol are closely associated with the risk for NAFLD. SBP (odds ratio [OR]: 1.092, 95% confidence interval [CI]: 1.030–1.158; P < 0.05) and DBP (OR: 1.157, 95%CI: 1.094–1.223; P < 0.05) were found to be independent risk factors for NAFLD. Our analysis indicates that BP is significantly associated with NAFLD in nonhypertensive individuals; SBP and DBP are found to be independent risk factors for NAFLD.

Effects of Resveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease—A Meta-Analysis

“…Yet, Timmers et al reported that resveratrol supplementation in obese patients at 150 mg a day over a period of 30 days brought down SBP by 5 mmHg. These inconsistent results may be attributed to dissimilar doses of resveratrol administered in the respective studies, and primarily to the comorbidity of non-alcoholic fatty liver disease, which is frequently accompanied by hypertension, an additional risk factor for the development of the disease [ 2 , 44 ].…”

Mean Arterial Pressure Is Related to Incident Nonalcoholic Fatty Liver Disease among the Nonobese Female with Normal Low-Density Lipoprotein Cholesterol Levels: A Large Cohort Study in China

“…Blood pressure (BP), including systolic blood pressure (SBP) and diastolic blood pressure (DBP), is an important risk factor for developing NAFLD [7][8][9][10], even in individuals without hypertension [10]. Mean arterial pressure (MAP), a steady component of BP, has wildly been used in clinical practice.…”

“…That is to say, NAFLD can increase the risk of developing hypertension, whereas hypertension also increases the risk of developing NAFLD. Meanwhile, research achievements that elevated SBP or DBP which is independently correlated with an increased risk of the incident NAFLD in general population emerge in endlessly recent years [7][8][9][10]. Interestingly, two of the studies indicated elevated blood pressure is associated with incident NAFLD in subjects without hypertension [8,10].…”

“…Meanwhile, research achievements that elevated SBP or DBP which is independently correlated with an increased risk of the incident NAFLD in general population emerge in endlessly recent years [7][8][9][10]. Interestingly, two of the studies indicated elevated blood pressure is associated with incident NAFLD in subjects without hypertension [8,10]. One study by Qian et al demonstrated that both SBP and DBP are independent risk factors for incident NAFLD in nonhypertensive subjects [10], while Wu et al argued that only the elevated SBP independently increases the risk of the incidence of NAFLD in subjects with normal SBP [8].…”

“…Interestingly, two of the studies indicated elevated blood pressure is associated with incident NAFLD in subjects without hypertension [8,10]. One study by Qian et al demonstrated that both SBP and DBP are independent risk factors for incident NAFLD in nonhypertensive subjects [10], while Wu et al argued that only the elevated SBP independently increases the risk of the incidence of NAFLD in subjects with normal SBP [8]. However, as far as we know, no data is available with respect to the correlation of MAP with incident NAFLD, not to mention a comparison of MAP with SBP or DBP for the prediction of NAFLD in nonobese population.…”