Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

Abstract

A A 2016 , ' Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas ' Acta Oto- Laryngologica , vol. 136 ,no. 5 , Conclusions BMI-1 is an upstream repressor of tumor suppressor p16 and their inverse expression patterns have been linked with patient survival in OPSCC. In this material only p16 remained a relevant prognostic marker in OPSCC. Objectives HNSCC tumors carry variable phenotypes and clinical outcomes depending on their anatomical location. In OPSCC, expression of tumor suppressor p16 is used as a surrogate marker of HPV infection and has prognostic value. There are no good prognostic biomarkers for HNSCC tumors of other anatomical locations. Aim To study the expression patterns of p16 and BMI-1 in not only oropharyngeal but also oral, hypopharyngeal, and laryngeal squamous cell carcinomas and to clarify their putative connections with clinical parameters, survival, and each other. Method Hospital records on 130 patients (59 OPSCC, 18 OSCC, 20 HPSCC, and 33 LSCC) diagnosed between 1997-2008 at the Helsinki University Hospital, Finland, were reviewed. BMI-1 and p16 expressions were studied by immunohistochemistry. Results Sixty-eight per cent of OPSCC expressed p16 and expression correlated with lower age, lower T-and higher N-category, and with improved OS and DFS. BMI-1 expression was most prevalent in OPSCC and LSCC, but had no clinical correlations. No correlation between p16 and BMI-1 expression was found.ARTICLE HISTORY

Human papillomavirus dysregulates the cellular apparatus controlling the methylation status of H3K27 in different human cancers to consistently alter gene expression regardless of tissue of origin

“…The lack of a consistent reduction in BMI1 expression in HPV+ tumors suggest that it is not a key factor in HPV activation of CDKN2A and CDKN2B transcription. This is supported by a smaller independent study that found no correlation between p16 and BMI1 expression in head and neck cancers [ 42 ].…”

“…For this reason, it seems unlikely that the induction of CDKN2A and CDKN2B expression observed in both these cancers is related to a reduction in expression of the BMI1 component of PRC1. This is further supported by a study reporting that BMI1 protein expression was lost in less than half of the 40 p16 positive oropharyngeal carcinoma oral tumors tested [ 42 ]. Thus, a loss of BMI1 expression appears unrelated to increased p16 transcription, at least in the context of oropharyngeal tumors.…”

Overexpression of Malic Enzyme 2 Indicates Pathological and Clinical Significance in Oral Squamous Cell Carcinoma

“…Furthermore, a recent study reported that SOX2, Slug and ALDH are overexpressed in human head and neck cancer [30][31][32][33]. Our result indicated that a close association between SOX2, Slug, ALDH1 and ME2.…”

Expression Profile of Survivin and p16 in Laryngeal Squamous Cell Carcinoma: Contribution of Tunisian Patients

“…Previous works reported that p16 positivity was detected in 3% to 97% of LSCC. [37][38][39] This controversial result might be due to biological behavior differences of tumors and variability in technical protocols. The immunostaining of p16 in our study was found in the nucleus and cytoplasm for all cases.…”