Association of body composition with function in women with early breast cancer

Aleixo, Gabriel F. P.; Deal, Allison M.; Nyrop, Kirsten A.; Muss, Hyman B.; Damone, Emily; Williams, Grant R.; Yu, Hyeon; Shachar, Shlomit Strulov

doi:10.1007/s10549-020-05624-3

Cited by 11 publications

(39 citation statements)

References 33 publications

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“…Similar findings regarding the importance of body composition in cancer outcomes have also been shown in other cancer studies. Recently, Aleixo et al reported that poor body composition with high visceral adipose tissue and lower muscle tissue and density is associated with physical function which, in turn, may affect treatment tolerability and other cancer outcomes among women with early stage breast cancer [36]. Moreover, Sheean and colleagues showed that obese women with estrogen receptor-positive metastatic breast cancer had significantly higher levels of abdominal obesity and serum biomarkers of inflammation, with a lower quality of life compared to women without obesity [37].…”

Section: Discussionmentioning

confidence: 99%

The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

et al. 2020

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Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.

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Section: Discussionmentioning

confidence: 99%

The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

et al. 2020

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“…Surprisingly, we were unable to find any other longitudinal study on whole-body or locomotor muscle mass for breast-cancer patients undergoing chemotherapy. As a loss of skeletal muscle mass is strongly associated with poor functional outcomes ( Fearon et al, 2011 ; Baracos et al, 2018 ; Cruz-Jentoft et al, 2019 ; Aleixo et al, 2020a ) and chemotherapy efficacy ( Caan et al, 2018 ; Lee et al, 2021 ) in breast cancer patients, further studies are needed to better characterize the loss of muscle mass in order to counteract it effectively thereafter.…”

Section: Chemotherapy-induced Skeletal Muscle Macroscopic Alterations In Breast Cancer Patientsmentioning

confidence: 99%

Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers

Mallard

Hucteau

Hureau

et al. 2021

Front. Cell Dev. Biol.

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Breast cancer represents the most commonly diagnosed cancer while neoadjuvant and adjuvant chemotherapies are extensively used in order to reduce tumor development and improve disease-free survival. However, chemotherapy also leads to severe off-target side-effects resulting, together with the tumor itself, in major skeletal muscle deconditioning. This review first focuses on recent advances in both macroscopic changes and cellular mechanisms implicated in skeletal muscle deconditioning of breast cancer patients, particularly as a consequence of the chemotherapy treatment. To date, only six clinical studies used muscle biopsies in breast cancer patients and highlighted several important aspects of muscle deconditioning such as a decrease in muscle fibers cross-sectional area, a dysregulation of protein turnover balance and mitochondrial alterations. However, in comparison with the knowledge accumulated through decades of intensive research with many different animal and human models of muscle atrophy, more studies are necessary to obtain a comprehensive understanding of the cellular processes implicated in breast cancer-mediated muscle deconditioning. This understanding is indeed essential to ultimately lead to the implementation of efficient preventive strategies such as exercise, nutrition or pharmacological treatments. We therefore also discuss potential mechanisms implicated in muscle deconditioning by drawing a parallel with other cancer cachexia models of muscle wasting, both at the pre-clinical and clinical levels.

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“…The most frequently studied patient groups were those with breast (n = 13), gastrointestinal (n = 8), lung (n = 6), and gynecologic cancers (n = 3). Eleven studies focused on patients who were receiving cancer treatment (Guest et al, 2013;Inglis et al, 2020;Kilgour et al, 2013;Kisiel-Sajewicz et al, 2013;Kumar et al, 2004;Morishita et al, 2018;Neefjes et al, 2017;Newton et al, 2018;Van Weert et al, 2006;Veni et al, 2019;Wang et al, 2020), five studies included patients who had completed chemotherapy (Basen-Engquist et al, 2009;Kalter et al, 2016;Tonosaki, 2012a;Winters-Stone et al, 2008, three studies included patients who were scheduled for chemotherapy (Aleixo et al, 2020;Coleman et al, 2011;Tonosaki, 2012b), and two studies included patients who were receiving palliative care (Brown et al, 2005;Schvartsman et al, 2017).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The quality of the selected studies was considered to be moderate to good. Most of the studies adequately reported the demographics of the study population and study setting (Aleixo et al, 2020;Brown et al, 2005;Coleman et al, 2011;Dhruva et al, 2010;Inglis et al, 2020;Kalter et al, 2016;Kilgour et al, 2013;Morishita et al, 2018;Neefjes et al, 2017;Tonosaki, 2012aTonosaki, , 2012bVeni et al, 2019;Wang et al, 2020;Winters-Stone et al, 2019). One study had a small sample size (n = 14) (Tonosaki, 2012b).…”

Section: Study Qualitymentioning

confidence: 99%

The Relationship Between Muscle Strength and Body Composition Measures and Cancer-Related Fatigue: A Systematic Review and Meta-Analysis

Li¹,

Chou²,

Shun³

2021

ONF

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Association of body composition with function in women with early breast cancer

Cited by 11 publications

References 33 publications

The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

Skeletal Muscle Deconditioning in Breast Cancer Patients Undergoing Chemotherapy: Current Knowledge and Insights From Other Cancers

The Relationship Between Muscle Strength and Body Composition Measures and Cancer-Related Fatigue: A Systematic Review and Meta-Analysis

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