Association of Body Mass Index, Body Fat, and Weight Gain With Inflammation Markers Among Rural Residents in Japan.

Saito, Isao; Yonemasu, Kunio; Inami, Fujiko

doi:10.1253/circj.67.323

Cited by 84 publications

(65 citation statements)

References 34 publications

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“…Anxietyassociated roles of such cytokines (48) likely contribute to their reported effects in autoimmune and atherosclerosis diseases. This finding, in turn, is compatible with the higher risk for inflammatory diseases with increasing age and BMI (49,50). Anxiety scores, in generally healthy subjects, may hence be relevant both for psychological and physiological symptoms.…”

Section: Discussionsupporting

confidence: 66%

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study

Sklan

Lowenthal

Korner

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

126

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Anxiety involves complex, incompletely understood interactions of genomic, environmental, and experience-derived factors, and is currently being measured by psychological criteria. Here, we report previously nonperceived interrelationships between expression variations and nucleotide polymorphisms of the chromosome 7q21-22 acetylcholinesterase-paraoxonase 1 (ACHE-PON1) locus with the trait-and state-anxiety measures of 461 healthy subjects from the Health, Risk Factors, Exercise Training, and Genetics Family Study. The AChE protein controls the termination of the stress-enhanced acetylcholine signaling, whereas the PON protein displays peroxidase-like activity, thus protecting blood proteins from oxidative stress damages. Serum AChE and PON enzyme activities were both found to be affected by demographic parameters, and showed inverse, reciprocal associations with anxiety measures. Moreover, the transient scores of state anxiety and the susceptibility score of trait anxiety both appeared to be linked to enzyme activities. This finding supported the notion of corresponding gene expression relationships. Parallel polymorphisms in the ACHE and PON1 genes displayed apparent associations with both trait-and state-anxiety scores. Our findings indicate that a significant source of anxiety feelings involves inherited and acquired parameters of acetylcholine regulation that can be readily quantified, which can help explaining part of the human variance for state and trait anxiety.

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Section: Discussionsupporting

confidence: 66%

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study

Sklan

Lowenthal

Korner

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

126

View full text Add to dashboard Cite

show abstract

“…Since total serum calcium is the sum of calcium bound to albumin and globulins and the free calcium fraction, this may confirm a positive relation between serum albumin and BMI (21). Furthermore, low levels of ionised calcium were found in 44 morbidly obese subjects in a study by Andersen et al (22).…”

Section: Discussionmentioning

confidence: 85%

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Kamycheva

Sundsfjord

Jorde

2004

European Journal of Endocrinology

176

103

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Objective: To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. Design: Population based, cross-sectional study. Methods:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical history and life-style factors were completed and anthropometric data were collected. Calcium and vitamin D intakes and a physical activity score were calculated. Serum calcium and PTH were measured in a subset of 3447 men and 4507 women. Pearson correlation and linear regression were used to evaluate associations between BMI, PTH and serum calcium, and logistic regression was used to test PTH and serum calcium as predictors of obesity and to calculate odds ratio. Relative risk was calculated using frequency tables. Results: For serum calcium and PTH there was a significant positive relation to BMI in both genders (P , 0.001), which to our knowledge has not previously been reported on the basis of a large epidemiological study. Age, low calcium and vitamin D intakes were explanatory variables for serum PTH. The highest quartile of serum PTH (.4.20 pmol/l) was a significant predictor for obesity (P , 0.001) in both genders, adjusted for age, physical activity and serum calcium. Obesity rates were higher in those with PTH levels in the highest quartile compared with those in the lower quartiles, which resulted in a relative risk of 1.40 (95% confidence interval (C.I.) 1.20 -1.60) for men and 1.48 (95% C.I. 1.31 -1.67) for women. Conclusions: Serum PTH, adjusted for age, physical activity and serum calcium, is positively associated with BMI in both sexes, and serum PTH is an independent predictor of obesity in our statistical model.

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“…Chronic low-grade inflammation Obesity in humans is considered a state of chronic inflammation, 59,83,84 and serum adipokines increase with fat mass, especially with visceral fat. Inflammation is characterized by inflammatory cytokine expression, Creactive protein (CRP) production, and increased white blood cell counts and white cell activity.…”

Section: Lipids and Lipid Oxidizabilitymentioning

confidence: 99%

“…59,83,84 Adiponectin, which improves insulin sensitivity and inhibits vascular inflammation, 79 is present at a low level in the plasma of obese persons but increases with weight loss. 89 A strong inverse relationship exists between adiponectin mRNA levels and CRP levels.…”

Section: Lipids and Lipid Oxidizabilitymentioning

confidence: 99%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

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Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation. Method: This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue. Results: Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets. Conclusion: Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.

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Association of Body Mass Index, Body Fat, and Weight Gain With Inflammation Markers Among Rural Residents in Japan.

Cited by 84 publications

References 34 publications

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study

Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

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