Association of Body Mass Index with Hearing Loss in Korean Adult Population

Koo, Jong-Seop; Kim, So Young

doi:10.3390/jpm12050786

Cited by 4 publications

(6 citation statements)

References 37 publications

(36 reference statements)

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“…This differs from our original hypothesis that hearing loss-related traits would increase body constitution pertaining to a GWAS study made in European participants 40 . It is however consistent with observations from a recent large study conducted in a cohort from the Republic of Korea (2009–2016) reporting a negative association between hearing loss and BMI 13 . There are unfortunately some important ethnic differences between our source data (European ancestors) use in the reverse MR and the aforementioned observation to corroborate evidence.…”

Section: Discussionsupporting

confidence: 92%

“…Amid this uncertainty, some studies found that low BMI was also positively associated with hearing loss 12 . This association was further supported by a recent large-scale Korean population study, which reported that lower BMI (< 18.5 kg/m 2 ) was associated with an increased risk of hearing loss 13 . The associations were stronger in men and old people than in women and young generations.…”

Section: Introductionsupporting

confidence: 56%

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A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

He,

Karhunen,

Pulakka

et al. 2023

Sci Rep

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Hearing loss and hearing disorders represent possible mediating pathways in the associations between noise exposures and non-auditory health outcomes. In this context, we assessed whether the noise-obesity associations should consider hearing functions as possible mediators and applied Mendelian randomisation (MR) to investigate causal relationships between body constitution and hearing impairments. We obtained genetic associations from publicly available summary statistics from genome-wide association studies in European ancestry adult populations (N= from 210,088 to 360,564) for (i) body constitution: body mass index (BMI), waist circumference (WC) and body fat percentage (BFP), and (ii) hearing loss: sensorineural hearing loss, noise-induced hearing loss, and age-related hearing impairment (ARHI). We employed colocalisation analysis to investigate the genetic associations for BMI and ARHI liability within an FTO locus. We conducted bi-directional MR for the ‘forward’ (from body constitution to hearing) and ‘reverse’ directions. We applied the random effects inverse variance-weighted method as the main MR method, with additional sensitivity analyses. Colocalisation analysis suggested that BMI and ARHI shared a causal variant at the FTO gene. We did not find robust evidence for causal associations from body constitution to hearing loss and suggested that some associations may be driven by FTO variants. In the reverse analyses, ARHI was negatively associated with BMI [effect size – 0.22 (95% CI – 0.44 to – 0.01)] and BFP [effect size – 0.23 (95% CI – 0.45 to 0.00)], supporting the notion that ARHI may diminish body constitution. Finally, our data suggest that there is no strong evidence that hearing explains the association between noise exposure and body constitution.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 56%

A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

He,

Karhunen,

Pulakka

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We rst hypothesised that hearing loss-related traits would increase body constitution. However, a very recent study based on The National Health Insurance Service Health Screening Cohort of the Republic of Korea (2009-2016) including 291,471 participants with hearing loss and 6,088,979 control participants reported a negative association between hearing loss and BMI [13], which was consistent with our nding.…”

Section: Discussionsupporting

confidence: 91%

“…Amid this uncertainty, some studies found that low BMI was also positively associated with hearing loss [12]. This association was further supported by a recent large-scale Korean population study, which reported that lower BMI (< 18.5 kg/m2) was associated with an increased risk of hearing loss [13].…”

Section: Introductionmentioning

confidence: 86%

Adult body constitution and hearing loss: a bidirectional Mendelian randomisation study

Karhunen

Pulakka

et al. 2023

Preprint

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Hearing-loss and -disorders represent possible mediating pathways in the associations between noise exposures and non-auditory health outcomes. In this context, we questioned whether the noise-obesity associations should consider hearing functions as possible mediators and applied Mendelian randomisation (MR) to investigate causal relationships between body constitution and hearing impairments. We obtained genetic associations from publicly available summary statistics from genome-wide association studies in European adult populations (N= from 210,088 to 360,564) for (i) body constitution: body mass index (BMI), waist circumference (WC) and body fat percentage (BFP), and (ii) hearing loss: sensorineural hearing loss, noise-induced hearing loss, and age-related hearing impairment (ARHI). We employed colocalisation analysis to investigate the genetic associations for BMI and ARHI liability within an FTO locus. We conducted bi-directional MR for the ‘forward’ (from body constitution to hearing) and ‘reverse’ directions. We applied the random-effects inverse variance-weighted method as the main MR method, with additional sensitivity analyses. Colocalisation analysis suggested that BMI and ARHI shared a causal variant at the FTOgene. We did not find robust evidence for causal associations from body constitution to hearing loss and suggested that some associations may be driven by FTO variants. In the reverse analyses, ARHI was negatively associated with BMI [effect size -0.22 (95% CI -0.44 to -0.01)] and BFP [effect size -0.23 (95% CI -0.45 to 0.00)], supporting the notion that ARHI may diminish body constitution. Finally, our data suggest that hearing may have little to no effect on explaining the association between noise exposure and body constitution.

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“…ARHL has been reported to be associated with Caucasian ethnicity [ 9 ] and lower socioeconomic status [ 10 ]. Associations between hearing loss and smoking [ 11 ], alcohol [ 12 ], and other chronic diseases, such as hypertension [ 13 ], diabetes [ 14 ], dyslipidemia [ 15 ], obesity [ 16 ], underweight [ 17 ], sarcopenia [ 18 ] and adiposity [ 19 ] have been reported. Short stature has been reported to be associated with a higher risk of hearing loss, potentially due to fetal growth issues involving insulin-like growth factor 1, which affects cochlear development [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in associated factors for age-related hearing loss

Nam,

Park,

Jeong

et al. 2024

PLoS ONE

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The prevalence and age of onset of hearing loss differ according to sex. This study aimed to identify associated factors for age-related hearing loss (ARHL) and determine whether there are differences between males and females regarding associated factors for ARHL. This cross-sectional study used data from adults who underwent medical examinations including hearing tests from 2011 to 2021. A total of 2,349 individuals were included. The study conducted sex-specific analyses using both univariate and multiple regression. Univariate analysis employed logistic regression, while multiple regression involved variable selection through the augmented backward elimination method. Separate multiple logistic regression analyses were conducted for each sex. In the univariate analysis, among males, age, underweight, alcohol consumption, weight, and height exhibited statistical significance. Among females, age, hypertension, diabetes, dyslipidemia, obesity, sarcopenia, weight, height, age at menarche, and duration of hormone exposure were found to be significant factors. However, in the multiple logistic regression model for males, underweight, and smoking emerged as significant, while in females, age, weight, obesity, and age at menarche retained their significance. We found that there are different associated factors for ARHL in each sex. Assessment and counseling for smoking, obstetric history, underweight, and obesity may be beneficial in managing patients with ARHL.

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Association of Body Mass Index with Hearing Loss in Korean Adult Population

Cited by 4 publications

References 37 publications

A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

Adult body constitution and hearing loss: a bidirectional Mendelian randomisation study

Sex differences in associated factors for age-related hearing loss

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