Association of Body Mass Index in Midlife With Morbidity Burden in Older Adulthood and Longevity

Khan, Sadiya S.; Krefman, Amy; Zhao, Lihui; Liu, Lei; Chorniy, Anna; Daviglus, Martha L.; Schiman, Cuiping; Liu, Kiang; Shih, Ya Chen Tina; Garside, Daniel B.; Vu, Thanh-Huyen T; Lloyd-Jones, Donald M; Allen, Norrina B

doi:10.1001/jamanetworkopen.2022.2318

Cited by 12 publications

(7 citation statements)

References 38 publications

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“…The paper revealed a close relationship between body mass index indicators and the presence of comorbid conditions, these data are consistent with the data by Khan et al . [ 22 ] obtained during a prospective cohort study of 29,621 patients. Based on the data obtained, it was found that lack of physical activity is one of the main factors contributing to the obesity epidemic, and it is often the goal of intervention, because it is amenable to change at the individual level, which does not contradict the data presented by Wiklund [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…The total cost of treating obesity and related comorbidities is very high and continues to grow, which is reflected in the indirect impact on the well-being of society and its productivity [21]. According to Khan et al [22] in the US, on average, spending per person in old age is significantly higher among overweight participants (12,390 USD [US Dollars] 95% confidence interval [CI] USD 10,427-14,354) and people with grade I and II obesity (USD 23,396, 95% CI USD 18,474-28,319) compared with participants with normal BMI (p < 0.001). Against the background of the COVID-19 pandemic, obesity was considered a clinically significant risk factor for severe disease [23].…”

Section: Introductionmentioning

confidence: 99%

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Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Tszyan

2024

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Introduction One of the urgent tasks of modern healthcare is the development of measures aimed at preventing obesity in the able-bodied population, including in the Republic of Kazakhstan, which would reduce economic losses and increase the coefficient of life expectancy in the population. Aim To identify measures for the early prevention of excess weight, obesity, and carbohydrate metabolism disorders in the able-bodied population at an industrial facility in Kazakhstan. Material and methods The study involved 662 people (574 men and 88 women) aged 19 to 64 years. The subjects were divided into 2 groups: the main group – persons with obesity (242 people) and the control group – relatively healthy persons (422 people). The diagnosis of obesity was made based on the medical history of a patient, external examination, and physical, laboratory, and instrumental assessment. Results Three main factors influencing the development of obesity have been identified: a significant level of inactivity; serum glucose; the presence of comorbidities. Other factors (gender and age, smoking) do not have a significant effect on the increase in the body mass index of persons working at an industrial facility. Conclusions Accordingly, a priority in the prevention of obesity is a healthy lifestyle, involving regular physical activity and a healthy balanced diet.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Tszyan

2024

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“…[73][74][75][76][77] In addition to greater burden of CVD, data demonstrate earlier onset of CVD among those with poor CKM health. [78][79][80] Herein, we review the evidence for risk markers of CKM health and their utility to improve precision and accuracy of risk assessment.…”

Section: Novel Risk Markers For Cvd and Ckm Health Metricsmentioning

confidence: 99%

Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association

Khan,

Coresh,

Pencina

et al. 2023

Circulation

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106

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Cardiovascular-kidney-metabolic (CKM) syndrome is a novel construct recently defined by the American Heart Association in response to the high prevalence of metabolic and kidney disease. Epidemiological data demonstrate higher absolute risk of both atherosclerotic cardiovascular disease (CVD) and heart failure as an individual progresses from CKM stage 0 to stage 3, but optimal strategies for risk assessment need to be refined. Absolute risk assessment with the goal to match type and intensity of interventions with predicted risk and expected treatment benefit remains the cornerstone of primary prevention. Given the growing number of therapies in our armamentarium that simultaneously address all 3 CKM axes, novel risk prediction equations are needed that incorporate predictors and outcomes relevant to the CKM context. This should also include social determinants of health, which are key upstream drivers of CVD, to more equitably estimate and address risk. This scientific statement summarizes the background, rationale, and clinical implications for the newly developed sex-specific, race-free risk equations: PREVENT (AHA Predicting Risk of CVD Events). The PREVENT equations enable 10- and 30-year risk estimates for total CVD (composite of atherosclerotic CVD and heart failure), include estimated glomerular filtration rate as a predictor, and adjust for competing risk of non-CVD death among adults 30 to 79 years of age. Additional models accommodate enhanced predictive utility with the addition of CKM factors when clinically indicated for measurement (urine albumin-to-creatinine ratio and hemoglobin A1c) or social determinants of health (social deprivation index) when available. Approaches to implement risk-based prevention using PREVENT across various settings are discussed.

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“…Obesity is a major health problem that increases the risk of cardiovascular diseases and shortens life expectancy [ 1 , 2 ]. However, in cardiac and non-cardiac surgery better outcome has been reported in overweight and obese than in normal weight patients, typically with a U-shaped association between body mass index (BMI) and mortality [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Association of body mass index with 30-day mortality and red blood cell transfusions in open heart surgery

Räsänen

Ellam

Hartikainen

et al. 2023

European Journal of Cardio-Thoracic Surgery

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Objectives Obesity is associated with increased burden of cardiovascular risk factors, morbidity and mortality. However, several studies have counterintuitively shown better outcome after cardiac surgery in obese than in normal weight patients, a phenomenon known as obesity paradox. Furthermore, obesity has been linked with decreased need of red blood cell transfusions. The purpose of this study was to evaluate the impact of body mass index on 30-day mortality and red blood cell transfusions in patients undergoing cardiac surgery, a clinically important topic with conflicting previous data. Methods We retrospectively investigated 1691 patients who underwent coronary and/or valve or aortic root surgery using cardiopulmonary bypass between 2013 and 2016. The patients were categorized by body mass index based on World Health Organization classification. For analysis, logistic regression was used with adjustment for potential confounding factors. Results Of the patients 28.7% were normal weight, 43.3% overweight, 20.5% mildly obese, and 7.5% severely obese. 30-day mortality was 1.9% without significant differences between the body mass index groups. 41.0% of patients received red blood cell transfusion. Overweight (odds ratio [OR] 0.75, 95% confidence interval [CI] 0.56-0.99, P = 0.045), mildly (OR 0.65, 95% CI 0.46-0.92, P = 0.016) and severely obese (OR 0.41, 95% CI 0.24-0.70, P =0.001) patients needed less frequently red blood cell transfusions than patients with normal weight. Conclusions Obesity was not associated with 30-day mortality but was associated with lower use of red blood cell transfusions in cardiac surgery.

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Association of Body Mass Index in Midlife With Morbidity Burden in Older Adulthood and Longevity

Abstract: This cohort study uses Medicare claims data to investigate the association between body mass index midlife and morbidity burden, longevity, and health care costs in adults 65 years or older.

Cited by 12 publications

References 38 publications

Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility

Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association

Association of body mass index with 30-day mortality and red blood cell transfusions in open heart surgery

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