Association of Bone Edema with the Progression of Bone Erosions Quantified by Hand Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis in Remission

Lisbona, M.; Pàmies, Anna; Ares, Jesús; Almirall, Míriam; Navallas, María; Solano, A.; Maymó, Joan

doi:10.3899/jrheum.130902

Cited by 21 publications

(18 citation statements)

References 37 publications

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“…when a joint is put under normal load from walking) has profound effects on cell behavior. A prime example of this in the clinic is bone marrow edema, where unnatural concentrations of stress on a person's bones cause cells (including hMSCs) to migrate away from the site of concentrated force, causing weakness and eventually erosion [59,60]). Alternatively, appropriate mechanical force can provide a strong environment for advantageous hMSC behavior and desirable differentiation.…”

Section: Enhanced Hmsc Functions On Electrospun Nano Scaffold With Camentioning

confidence: 99%

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

Holmes

Fang

Zarate

et al. 2016

Carbon

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Cartilage as a tissue in the body possesses a low regenerative capacity and is extremely difficult to repair. Today, treatment of cartilage injury, degeneration and defects presents critical clinical challenges, yet none of the currently available cartilage treatments provides a perfect solution. Since natural cartilage extracellular matrix is a nanoscaled structure, the main objective of this study is to design a novel biomimetic nanostructured cartilage construct via electrospinning and carbon nanomaterials for enhancing human bone marrow mesenchymal stem cell chondrogenic differentiation. For this purpose, we synthesized a carbon nanomaterial mixture, using a plasma arc discharge method, consisting of graphene nanoplatelets and single walled carbon nanotubes. This nanomaterial was then incorporated into electrospun polycaprolactone (PCL) microfibrous scaffolds, with and without an additional poly-L-lysine surface coating. Scaffolds were thoroughly characterized for both their biomimetic features and biocompatibility. Our results showed that our scaffolds with carbon nanomaterial have greatly improved mechanical properties and enhanced stem cell adhesion, proliferation and chondrogenic differentiation than PCL controls without carbon nanomaterials, and thus hold promise for improving cartilage formation in future in vivo studies and clinical applications.

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Section: Enhanced Hmsc Functions On Electrospun Nano Scaffold With Camentioning

confidence: 99%

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

Holmes

Fang

Zarate

et al. 2016

Carbon

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“…These data suggest a link between BME and structural damage in RA. Indeed, the importance of BME is supported by several studies showing that BME is a predictor of radiographic evidence of progression [ 5 – 13 ]. A recent study even showed that the persisting presence of BME is associated with an odds ratio (OR) of 60 for erosive progression at the same location [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF

et al. 2016

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BackgroundIn rheumatoid arthritis (RA) bone marrow edema (BME, osteitis) and anti-citrullinated protein antibodies (ACPA) are associated with radiographic progression. ACPA have been associated with BME, but it is unknown if this association is confined to ACPA and BME. We performed cross-sectional analysis of the association of ACPA, rheumatoid factor (RF) and anti-carbamylated protein (anti-CarP) antibodies with BME and other types of inflammation (synovitis, tenosynovitis) detected by magnetic resonance imaging (MRI).MethodsDisease-modifying antirheumatic drug (DMARD)-naïve patients with early arthritis (n = 589), included in the Leiden Early Arthritis Clinic cohort, underwent contrast-enhanced 1.5 T MRI of unilateral wrist, metacarpophalangeal and metatarsophalangeal-joints at baseline. BME, synovitis and tenosynovitis were scored by two readers. ACPA, rheumatoid factor (RF) and anti-CarP were determined at baseline.ResultsIn univariable analyses ACPA-positive patients had higher BME scores than ACPA-negative patients (median 4.5 vs. 2.0, p < 0.001), but not more synovitis and tenosynovitis. Also RF (median 3.75 vs. 2.0, p < 0.001) and anti-CarP antibodies (median 3.5 vs. 2.5, p = 0.012) were associated with higher BME scores. Because the autoantibodies were concomitantly present, analyses were stratified for the presence of different autoantibody combinations. ACPA-positive (ACPA+), RF-negative (RF-), anti-CarP-negative (anti-CarP-) patients did not have higher BME-scores than ACPA-negative (ACPA-), RF-, anti-CarP- patients. However ACPA+, RF-positive (RF+), anti-CarP- patients and ACPA+, RF+, anti-CarP-positive (anti-CarP+) patients had higher BME scores than ACPA-, RF-, anti-CarP- patients (median 5.0 and 4.5 vs. 2.0, p < 0.001 and p < 0.001). ACPA levels were not associated with BME scores. Analyses within RA- and UA-patients revealed similar results.ConclusionsThe presence of ACPA alone or ACPA level was not statistically significantly associated with BME scores, but the combined presence of ACPA and RF was associated with more BME. This suggests an additive role of RF to ACPA in mediating osteitis.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-016-1076-0) contains supplementary material, which is available to authorized users.

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“…On one hand, the lack of ultrasound activity predicts achievement and persistence of remission (33,34). On the other hand, there is a very high degree of confidence that residual synovial activity is a significant predictor for loss of remission (relapse, flare) and radiographic progression since controlled studies (35)(36)(37), meta-analyses (38,39), magnetic resonance imaging (MRI) studies (40)(41)(42)(43)(44)(45)(46), biological markers (14) and histology (47,48) have confirmed the cited ultrasound observations. The loss of remission tends to happen in the first year of follow-up (39), especially if treatment is withdrawn (49,50).…”

Section: Introductionmentioning

confidence: 72%

Clinical and ultrasound ankle involvement in rheumatoid arthritis in remission

Enache¹,

Popescu²,

Codreanu³

et al. 2019

Ro J Rheumatol.

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Objective. We aimed to evaluate the prevalence and differences of clinical and ultrasound involvement of ankles in rheumatoid arthritis (RA) patients in remission. Methods. RA patients were recruited in 2018 in the random order of presentation from the outpatient clinic. In the day of enrolment, all patients underwent clinical examination (by a senior rheumatologist, blind to other evaluations), inflammatory markers (e.g. C-reactive protein-CRP) and ankle ultrasound (performed and interpreted by a single rheumatologist with more than 7 years of experience). Results. The sample included 59 patients in DAS28CRP remission, 27 in SDAI remission and 20 in Boolean remission. Among these 3 categories of remission, overall clinical ankle involvement presented similar prevalence (revolving around 30%). On average, 77% of patients presented overall ultrasound ankle involvement among the 3 categories of remission, with similar frequencies of ankle joint synovial hypertrophy (SH; 33%), power Doppler (PD) positive joint SH (15%), ankle joint effusion (60%), ankle tenosynovitis (27%) and PD positive ankle tenosynovitis (15%). In the subgroup of RA patients in DAS28CRP remission, compared to patients without clinical or ultrasound ankle involvement, those with at least one involved ankle had a significantly higher median CRP (0.34 mg/dl versus 0.19 mg/dl, p = 0.042). Conclusion. Among RA patients in remission, regardless of its definition, clinical and ultrasound involvement of ankles is frequent. Clinical and ultrasound screening of ankles in RA patients in remission seems an appropriate strategy.

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Association of Bone Edema with the Progression of Bone Erosions Quantified by Hand Magnetic Resonance Imaging in Patients with Rheumatoid Arthritis in Remission

Cited by 21 publications

References 37 publications

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials

MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF

Clinical and ultrasound ankle involvement in rheumatoid arthritis in remission

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