Association of Bone Mineral Density with Chronic Obstructive Pulmonary Disease in Postmenopausal Women

Abstract

Background: Osteoporosis (OP) is common in patients with chronic obstructive pulmonary disease (COPD). The relationship between OP and COPD has been primarily studied in male patients, and few reports are available in postmenopausal women. Objective: The purpose of this study was to investigate the association between bone mineral density (BMD) and COPD in postmenopausal women. Methods: This cross-sectional study included 133 clinically stable female ex-smokers with confirmed COPD, and 31 age-matched "ex-smoker" female controls. We analyzed groups according to their airway obstruction category. BMD was measured on dual-energy X-ray absorptiometry images of the left femoral neck. Results: Patients with COPD had lower T-scores and higher prevalence of osteopenia/OP than the control group. In the COPD group, the airway obstruction category was significantly associated with the T-score after adjustment for confounders. Multivariate logistic regression analysis showed COPD was an independent marker for increased risk of osteopenia/OP in postmenopausal women. Conclusions: COPD and airway obstruction category were strongly related to BMD. Postmenopausal women with COPD, especially those with severe airway obstruction, had a higher prevalence rate and a higher risk of osteopenia and OP than female controls without COPD.

Association Between Osteoporosis Self-Assessment Tool for Asians and Airflow Limitation in Japanese Post-Menopausal Women

“…A previous study, which recruited post-menopausal women aged ≥50 years with diagnosed COPD and age-matched past smokers, demonstrated that moderate-to-very severe airway obstruction were related to osteopenia and osteoporosis BMD in patients with COPD. 28 Moreover, research conducted using data from the Third National Health and Nutrition Examination Survey reported that severe AL is a risk factor for osteopenia and osteoporosis. 29 We evaluated more participants and FEV 1 /FVC using prebronchodilator spirometry; however, there were no participants with severe or very severe AL and a small number of moderate AL (n=19) and current smokers (n=58).…”

Osteoporosis self-assessment tool for Asians as a risk assessment tool of airflow limitation in Japanese post-menopausal women

“…Moreover, lower FEV 1 /FVC was observed in the OSTA high-risk group; however, this was not signi cantly different among the three groups classi ed according to BMD category, and we found no relationship between FEV 1 /FVC and BMD in this study. A previous study, which recruited postmenopausal women aged ≥ 50 years diagnosed with COPD and age-matched past smokers, demonstrated that moderate-to-very severe airway obstruction are related to osteopenia and osteoporosis BMD in patients with COPD [23]. Moreover, research conducted using data from the Third National Health and Nutrition Examination Survey reported that severe AL is a risk factor for osteopenia and osteoporosis [24].…”

Constitutions of Deficiency and Stasis of Traditional Chinese Medicine and Related Factors among Middle‐Aged Women in Taiwan

“…The risk of osteoporosis and fragility fractures can be reduced through healthy lifestyle changes [ 18 , 19 ]. Chronic obstructive pulmonary disease and airway obstruction were also related to bone mineral density in postmenopausal women [ 20 ]. Those symptoms were consistent with the performance of constitutions in deficiency and stasis [ 7 , 21 ].…”