Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study

Zeng, Xiang; Liu, Dongling; Zhao, Xin; Chao, Ling; Li, Yuchun; Li, Huijun; Li, Wen; Gui, Lihui; Wu, Weidong

doi:10.1186/s12890-019-1008-2

Cited by 17 publications

(16 citation statements)

References 41 publications

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“…To our expectation, we did not find enrichments of stomach, liver, or lung OCRs for genetic variants associated with brain-related traits. We did find enrichment of BMD in lung OCRs, a connection previously recognized (Lee et al, 2016;Kim et al, 2019;Zeng et al, 2019). The secondary GWAS enrichments in other traits and foregrounds demonstrate two trends: a GWAS trait would enrich if the GWAS was properly powered to detect genetic risk variants, and the foreground regions are from cell types or tissue of that trait's potential etiological origin.…”

Section: Genetic Risk For Substance Use Traits Is Associated With Thesupporting

confidence: 51%

Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology

Srinivasan

Phan

Lawler

et al. 2020

Preprint

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Recent large genome-wide association studies (GWAS) have identified multiple confident risk loci linked to addiction-associated behavioral traits. Genetic variants linked to addiction-associated traits lie largely in non-coding regions of the genome, likely disrupting cis-regulatory element (CRE) function. CREs tend to be highly cell type-specific and may contribute to the functional development of the neural circuits underlying addiction. Yet, a systematic approach for predicting the impact of risk variants on the CREs of specific cell populations is lacking. To dissect the cell types and brain regions underlying addiction-associated traits, we applied LD score regression to compare GWAS to genomic regions collected from human and mouse assays for open chromatin, which is associated with CRE activity. We found enrichment of addiction-associated variants in putative regulatory elements marked by open chromatin in neuronal (NeuN+) nuclei collected from multiple prefrontal cortical areas and striatal regions known to play major roles in reward and addiction. To further dissect the cell type-specific basis of addiction-associated traits, we also identified enrichments in human orthologs of open chromatin regions of mouse neuron subtypes: cortical excitatory, PV, D1, and D2. Lastly, we developed machine learning models from mouse cell type-specific regions of open chromatin to further dissect human NeuN+ open chromatin regions into cortical excitatory or striatal D1 and D2 neurons and predict the functional impact of addiction-associated genetic variants. Our results suggest that different neuron subtypes within the reward system play distinct roles in the variety of traits that contribute to addiction.

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Section: Genetic Risk For Substance Use Traits Is Associated With Thesupporting

confidence: 51%

Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology

Srinivasan

Phan

Lawler

et al. 2020

Preprint

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“…Previous studies observed a higher bone mass and fewer bone fractures among subjects from rural areas than urban areas. 110–121 Several factors such as occupation, lifestyle, physical activity, dietary pattern and traffic accident are attributed to this observation. It would be interesting to ask whether air quality could contribute to the difference in bone health between rural and urban populations.…”

Section: Discussionmentioning

confidence: 79%

Particulate Air Pollution and Osteoporosis: A Systematic Review

Pang

Ekeuku

Chin

2021

RMHP

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Air pollution is associated with inflammation and oxidative stress, which predispose to several chronic diseases in human. Emerging evidence suggests that the severity and progression of osteoporosis are directly associated with inflammation induced by air pollutants like particulate matter (PM). This systematic review examined the relationship between PM and bone health or fractures. A comprehensive literature search was conducted from January until February 2021 using the PubMed, Scopus, Web of Science, Google Scholar and Cochrane Library databases. Human cross-sectional, cohort and case–control studies were considered. Of the 1500 papers identified, 14 articles were included based on the inclusion and exclusion criteria. The air pollution index investigated by most studies were PM 2.5 and PM 10 . Current studies demonstrated inconsistent associations between PM and osteoporosis risk or fractures, which may partly due to the heterogeneity in subjects’ characteristics, study design and analysis. In conclusion, there is an inconclusive relationship between osteoporosis risk and fracture and PM exposures which require further validation.

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“…Several factors may explain the higher incidence of hip fractures among COPD patients. On the one hand, patients with poorer lung function tend to show a greater decrease in bone mass, 29 and on the other hand, patients with COPD experience more falls than those without. 7 Finally, patients with frequent COPD exacerbations are intermittently treated with high doses of systemic corticosteroids that can contribute to the appearance of fractures.…”

mentioning

confidence: 99%

<p>Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort</p>

Díez-Manglano¹,

Vidal²,

Barredo³

et al. 2020

COPD

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Purpose: To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Patients and Methods: Observational nested case-control study was conducted in Aragon, Spain in 2010. We included COPD patients aged >40 years, in the EpiChron cohort. Each COPD patient was matched for age, sex, and number of comorbidities with a control subject without COPD. Patients with an existing diagnosis of osteoporosis and those with hip fracture before 2011 were excluded. We collected baseline demographic, comorbidity, and pharmacological treatment data. During a 5-year follow-up period, we recorded the incidence of hip fracture. A logistic regression model was constructed to identify factors associated with hip fracture. Results: The study population consisted of 26,517 COPD patients and the same number of controls (median [interquartile range] age, 74 [17] years; women, 24.7%). Smoking and heart failure were more frequent in COPD patients, and obesity, hypertension, diabetes, dyslipidemia, stroke, arthritis, and visual or hearing impairment were less frequent (all p<0.001). Consumption of benzodiazepines (p=0.037), bronchodilators (p<0.001), and corticosteroids (p<0.001) was higher in the COPD group, while that of beta-blockers and thiazides was lower (both p<0.001). During follow-up, 898 (1.7%) patients experienced hip fracture, with no differences observed between COPD and control patients. Multivariate analysis revealed that independent of COPD status, age, female sex, chronic liver disease, heart failure, and benzodiazepine use were independently associated with a higher risk of hip fracture, and obesity with a lower risk. In COPD patients, use of inhaled anticholinergics was independently associated with hip fracture (OR, 1.390; 95% CI 1.134-1.702; p=0.001). Conclusion: COPD is not a risk factor for a hip fracture within 5 years. The association between the use of inhaled anticholinergics and risk of hip fracture warrants further study.

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Association of bone mineral density with lung function in a Chinese general population: the Xinxiang rural cohort study

Cited by 17 publications

References 41 publications

Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology

Addiction-associated genetic variants implicate brain cell type- and region-specific cis-regulatory elements in addiction neurobiology

Particulate Air Pollution and Osteoporosis: A Systematic Review

<p>Chronic Obstructive Pulmonary Disease and Incidence of Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort</p>

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