Association of bovine DRB3 alleles with immune response to FMDV peptides and protection against viral challenge

García-Briones, María Mercedes; Russell, George C.; Oliver, R. A.; Tami, Cecilia; Taboga, Oscar; Carrillo, Elisa; Palma, Eduardo L.; Sánchez‐Madrid, Francisco; Glass, Elizabeth J.

doi:10.1016/s0264-410x(00)00313-3

Cited by 53 publications

(46 citation statements)

References 13 publications

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“…In particular, the amino acid residues 70-71 of the OLA-DRβ1 domain from peptide-binding pocket 4 might be the most important sites in immune responses. Likewise, several previous studies revealed a strong association between BoLA-DRB3 and sensitivity to subclinical progression of BLV (48) and BLV-induced lymphoma (1) as well as immune response by peptide vaccine against Foot-andMouth disease virus (FMDV) (12). Furthermore, Haghparast et al (15) reported that the affinity of the FMDV epitope peptides to bind to certain BoLA-DRB3 molecules was significantly correlated with the capacity to induce T-cell proliferation.…”

Section: Discussionmentioning

confidence: 92%

The Influence of Ovine MHC Class IIDRB1Alleles on Immune Response in Bovine Leukemia Virus Infection

Konnai

Takeshima

Tajima

et al. 2003

Microbiology and Immunology

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We have reported previously that the alleles of the ovine leukocyte antigen (OLA)‐DRB1 gene that encode the Arg‐Lys (RK) motif and the Ser‐Arg (SR) motif at positions β70/71 of the OLA‐DRβ1 domain are associated with resistance and susceptibility, respectively, to development of bovine leukemia virus (BLV)‐induced ovine lymphoma. Here, to investigate the different immune response in sheep that carried alleles associated with resistance and susceptible for 30 weeks after infection with BLV, we selected sheep that had the RK/RK or SR/SR genotype among the 52 sheep analyzed by polymerase chain reaction‐restriction fragment length polymorphism and DNA sequencing of PCR product for the OLA‐DRB1 exon 2 and infected them with BLV. Although the number of BLV‐infected cells and virus titer had been maintaining low levels throughout the experimental period, the sheep with the RK/RK genotype could induce expansion of CD5− B‐cells and rapid production of neutralizing antibody in the early phase of infection. The level of incorporation of [3H]thymidine by peripheral blood mononuclear cells from the sheep with RK/RK genotype gave a strong response to BLV virion antigen and synthetic antigenic peptides that corresponded to T‐helper epitope of the BLV envelope glycoprotein gp51. In contrast, the sheep with SR/SR genotype showed a strong response to BLV virion antigen and synthetic antigenic peptides that corresponded to T‐cytotoxic and B‐cell epitopes. In such cases, the animals with the RK/RK strongly expressed IFN‐7, the animals with SR/SR genotype strongly expressed IL‐2. To determine the proliferating cells, we tried a blocking assay with monoclonal antibodies such as anti‐CD4, ‐CD8 and ‐DR molecule. We found that these proliferating cells were MHC‐restricted CD4+ T‐cells.

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Section: Discussionmentioning

confidence: 92%

The Influence of Ovine MHC Class IIDRB1Alleles on Immune Response in Bovine Leukemia Virus Infection

Konnai

Takeshima

Tajima

et al. 2003

Microbiology and Immunology

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“…In addition, two tandem peptides containing the sequence of the continuous B-cell epitope VP1 [137][138][139][140][141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156] juxtaposed to the T-cell epitope 3A [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35], in the two possible orientations (peptides BT and TB; Table 1), were prepared. Both peptides were synthesized as C-terminal carboxamides by Boc-based solid-phase methods (12) in semiautomated mode, with systematic ninhydrin control and recoupling as required.…”

Section: Methodsmentioning

confidence: 99%

“…Inclusion of one of these T-cell epitopes identified in VP1 residues 21 to 40 in a tandem peptide with the B-cell site A has been shown to overcome individual nonresponsiveness of cattle to peptide A (17). However, the recognition of this and other T-cell epitopes identified in FMDV capsid proteins is significantly restricted by the MHC polymorphism of the host species (24,26,39), and their potential to improve synthetic vaccines is, therefore, limited. Yet T-cell epitopes relevant to the induction of a protective response have also been described in the NSP of several viruses (13,27).…”

mentioning

confidence: 99%

Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus

Blanco

García-Briones

Sanz-Parra

et al. 2001

J Virol

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“…Such T cell peptides should ideally be recognised by T lymphocytes in the context of alleles of MHC class II frequently represented in the populations of the natural hosts [194]. Even when G-H loop peptides can stimulate T cells of individuals from host species [105,189,232,252], this recognition seems to be considerably restricted by the individual MHC composition [101,[104][105][106]239], and may vary depending on the sequence of the viral peptide used [105]. Immunisation with peptides including the G-H loop either alone or in combination with an independent T cell epitope has been reported recently [232], using a large number of cattle.…”

Section: Peptide Vaccinesmentioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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-Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV has become a model system in animal virology and a considerable amount of information on its structure, biology and vaccinology has been obtained. However, the disease that this virus produces (FMD) still constitutes one of the main animal health concerns. In this review, we have attempted to summarise the state of the knowledge in different basic and applied areas of FMDV research, with emphasis on those aspects relevant to the control of the disease. FMDV / structure / immunity / vaccine / variability / diagnosisRésumé -Le virus de la fièvre aphteuse : un virus connu de longue date, qui demeure une menace. Le virus de la fièvre aphteuse a été le premier virus animal identifié. Depuis lors, il est devenu un système modèle en virologie animale, et une quantité importante d'informations sur sa structure, sa biologie et sa vaccinologie a été obtenue. Cependant la maladie provoquée par ce virus constitue encore une inquiétude majeure en santé animale. Dans cette revue, nous avons tenté de résumer l'état des connaissances dans différents domaines de recherche, à la fois fondamentaux et appliqués, sur le virus de la fièvre aphteuse, en mettant l'accent sur les aspects relatifs au contrôle de la maladie. virus de la fièvre aphteuse / immunité / vaccin / variabilité / diagnostic

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Association of bovine DRB3 alleles with immune response to FMDV peptides and protection against viral challenge

Cited by 53 publications

References 13 publications

The Influence of Ovine MHC Class IIDRB1Alleles on Immune Response in Bovine Leukemia Virus Infection

The Influence of Ovine MHC Class IIDRB1Alleles on Immune Response in Bovine Leukemia Virus Infection

Identification of T-Cell Epitopes in Nonstructural Proteins of Foot-and-Mouth Disease Virus

Foot-and-mouth disease virus: a long known virus, but a current threat

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