Association of BPD and IVH with early neutrophil and white counts in VLBW neonates with gestational age &lt;32 weeks

Palta, Mari; Sadek-Badawi, Mona; Carlton, David P.

doi:10.1038/jp.2008.65

Cited by 16 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Palta, M et. al found low neutrophil count (< 1*10 9 /l) predicted the BPD severity level (OR: 1.7, 95% CI:1.1–2.7) in very low birth weight (VLBW) infants [16], which is opposite to findings in the current study. Noticeably, a neutrophil count of less than 1*10 9 /l was only detected in 5 infants without BPD and 6 infants with moderate-severe BPD.…”

Section: Discussioncontrasting

confidence: 99%

Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants

Chen

Qiu

et al. 2019

BMC Pediatr

View full text Add to dashboard Cite

Objective To evaluate the association between hematological parameters at birth and the risk of moderate-severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. Methods This is a retrospective study of all extremely premature infants admitted to the neonatal intensive care unit, Shenzhen Maternity and Child Healthcare Hospital from January 2016 to May 2018. Extremely prematurity was defined as a delivery at a gestational age ≤ 28 weeks or a birth weight ≤ 1000 g. BPD was diagnosed if oxygen exposure exceeded 28 days and the severity was decided at 36 weeks PMA or discharge. Multivariable analysis was performed to assess the independence of the association between hematological parameters at birth and risk of moderate or severe BPD. Results A total of 115 extremely premature infants were analyzed in this study. The median platelet count, neutrophil and monocyte count at birth were significantly higher in infants with moderate-severe BPD compared to infants without BPD (228 vs 194*10 9 /l, P = 0.004; 5.0 vs 2.95*10 9 /l, P = 0.023; 0.88 vs 0.63*10 9 /l, P = 0.026, respectively) whereas the mean platelet volume was significantly lower in infants with moderate-severe BPD than those without BPD (9.1 vs 9.4 fl, P = 0.002). After adjusting for covariates, the risk of moderate-severe BPD was independently associated with platelet count≥207*10 9 /l (odds ratio 3.794, 95% confidence interval: 1.742–8.266, P = 0.001). Conclusion Our findings suggest that hematologic parameters at birth are different in extremely preterm infants who will develop moderate-severe BPD. A higher platelet count at birth may increase the risk of moderate-severe BPD after extremely premature birth.

show abstract

Section: Discussioncontrasting

confidence: 99%

Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants

Chen

Qiu

et al. 2019

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…A recently published study showed a strong association of early low leukocyte and neutrophil counts in preterm infants at the gestational age of <32 weeks with the severity of BPD. 21 Our data did not show higher BPD rate in the SGA group, despite lower leukocyte and neutrophil counts, compared with the AGA infants. Other investigators have reported an association between early onset neutropenia and sepsis.…”

Section: Discussioncontrasting

confidence: 73%

Intrauterine Growth Retardation in Preterm Infants ≤32 Weeks of Gestation is Associated with Low White Blood Cell Counts

Wirbelauer¹,

Thomas²,

Rieger

et al. 2010

Amer J Perinatol

View full text Add to dashboard Cite

It is unclear if very immature preterm infants who are born small for gestational age (SGA) have similar leukocyte counts as infants who are born appropriate for gestational age (AGA). Our study included 49 preterm infants with a gestational age ≤32 weeks and without exposure to chorioamnionitis and funisitis. Blood cells were counted in the first 2 hours of life. Eighteen SGA preterm infants were compared with 31 AGA preterm infants. Gestational age, sex, rate of caesarean section, and prenatal administration of corticosteroids did not differ between the groups. Median birth weight was 583 g in the SGA group versus 1100 g in the AGA group. Infants in the SGA group had significantly lower counts of leukocytes, total neutrophils, immature neutrophils, lymphocytes, and monocytes. These findings were not affected by maternal preeclampsia. No significant difference for nucleated red blood cell counts was found. Prenatal growth retardation is an independent factor for lower counts of different leukocytes in very immature preterm infants. It is not clear if these low leukocyte counts are associated with a higher risk of neonatal infections or if lower numbers of inflammatory cells protect the lung and brain of very immature SGA infants by reducing inflammatory events postnatally.

show abstract

“…Preterm participants were recruited from the Newborn Lung Project (Palta and Sadek‐Badawi ; Palta et al. ), a cohort established at the University of Wisconsin (Madison, WI) that enrolled individuals born preterm (≤36 weeks gestation) with very low birth weight (<1500 g) in 2003 and 2004 in Wisconsin. The Newborn Lung Project also included normal birth weight (NBW) term‐born children whose addresses were obtained from 2003 to 2004 Wisconsin birth records (Palta and Sadek‐Badawi ), from which 14 controls were recruited.…”

Section: Methodsmentioning

confidence: 99%

Impaired autonomic function in adolescents born preterm

et al. 2018

View full text Add to dashboard Cite

Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long‐term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm. Adolescents born preterm (less than 36 weeks gestation at birth) in 2003 and 2004 and healthy age‐matched full‐term controls participated. Wilcoxon Rank Sum tests were used to compare variables between control and preterm groups. Twenty‐one adolescents born preterm and 20 term‐born controls enrolled in the study. Preterm‐born subjects had lower time‐domain HRV, including SDRR (69.1 ± 33.8 vs. 110.1 ± 33.0 msec, respectively, P = 0.008) and RMSSD (58.8 ± 38.2 vs. 101.5 ± 36.2 msec, respectively, P = 0.012), with higher LF variability in preterm subjects. HRR after maximal exercise was slower in preterm‐born subjects at 1 min (30 ± 12 vs. 39 ± 9 bpm, respectively, P = 0.013) and 2 min (52 ± 10 vs. 60 ± 10 bpm, respectively, P = 0.016). This study is the first report of autonomic dysfunction in adolescents born premature. Given prior association of impaired HRV with adult cardiovascular disease, additional investigations into the mechanisms of autonomic dysfunction in this population are warranted.

show abstract

Association of BPD and IVH with early neutrophil and white counts in VLBW neonates with gestational age <32 weeks

Abstract: Objective: To investigate associations between early low neutrophil count from routine blood samples, white blood count (WBC), pregnancy complications and neonatal outcomes for very low birth weight infants (VLBW p1500 g) with gestational age <32 weeks.

Cited by 16 publications

References 17 publications

Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants

Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants

Intrauterine Growth Retardation in Preterm Infants ≤32 Weeks of Gestation is Associated with Low White Blood Cell Counts

Impaired autonomic function in adolescents born preterm

Contact Info

Product

Resources

About