Association of Brain Cancer With Risk of Suicide

Saad, Anas M.; Elmatboly, Abdelmagid M.; Gad, Mohamed M.; Al‐Husseini, Muneer J.; Jazieh, Khalid; Alzuabi, Muayad; Alfaar, Ahmad Samir

doi:10.1001/jamanetworkopen.2020.3862

Cited by 15 publications

(22 citation statements)

References 7 publications

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“…The presence of depression and anxiety significantly reduces patients’ quality of life and can even result in suicide [ 10 ]. As recently demonstrated, patients with glioblastoma were four times more likely to commit suicide within the first year after diagnosis, compared to patients with less malignant brain tumour types, including LGG, who had a doubled risk compared to the general population [ 11 ]. Studies on the prevalence of depression in patients with brain tumours have reported large variations (range 0–93% [ 12 , 13 ]).…”

Section: Introductionmentioning

confidence: 99%

Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

et al. 2021

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Background Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patients with LGG, less is known about depression and anxiety. Methods We used nationwide registers to study the use (dispense) of antidepressants, sedatives, and anti-epileptic drugs (AEDs) before and after histopathological LGG diagnosis (WHO grade II). A total of 485 adult patients with a first-time diagnosis and a matched control cohort (n = 2412) were included. Patterns of use were analysed from one year prior to until one year following index date (date of surgery). Logistic regression analysis identified predictors for postoperative use. Results At one year before index date, patients were dispensed AEDs 4 times more than controls, while antidepressants and sedatives were similar. Sedatives and AED peaked shortly after index date at 25 and 69%, respectively. AEDs then stabilized while sedatives decreased rapidly. For antidepressants, a delayed increase was seen after index date, stabilizing at 12%. At one year after index date, the use of antidepressants, sedatives, and AEDs among patients was 2, 3, and 26 times higher, respectively, compared to controls. Predictor for use of AEDs and sedatives at one year following index was previous use and/or a related diagnosis. Female sex and later index year were additional predictors for antidepressants. Conclusions Use of antidepressants, sedatives and AEDs is elevated following diagnosis of LGG. Antidepressants were more commonly dispensed to female patients and in recent years.

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Section: Introductionmentioning

confidence: 99%

Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

et al. 2021

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“…Haider et.al reported the highest suicide rates within the first year following diagnosis among women with gynaecologic cancer, with an SMR of 2.8 8 . Further, prior research has shown that significantly higher risks of suicide were observed among patients diagnosed with breast cancer 19 , brain cancer 20 , male genital-system 21 , and skin malignant melanoma 22 within the first year of diagnosis. We thought it reasonable as the change from being a healthy individual to being a cancer patient who had a poor prognosis created a new perception of identity.…”

Section: Discussionmentioning

confidence: 97%

Suicide and Accidental Death Among Women with Primary Ovarian Cancer: A population-based study

Chen¹,

Kang²,

Zhu³

et al. 2021

Preprint

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Objective To determine the relative risk of suicide and accidental death among patients with ovarian cancer to that of the general population, and to identify risk factors associated with suicide and accidental death. Design The surveillance, epidemiology, and end results (SEER) registry provided ovarian cancer data from 18 registries. Setting Surveillance, Epidemiology, and End Results database. Population The study population comprised 149,204 patients. Methods The standardized mortality ratios (SMRs) were calculated and Fine-Gray models were fitted, with stratifications on demographic and tumor-related characteristics. Main outcome measures The standardized mortality ratios. Results Women with ovarian cancer had a higher risk of suicide and accidental death than the cancer-free group (SMR=1.86; 95% CI [1.54-2.25] and SMR=1.54; 95% CI [1.39-1.71]). Subgroup analysis indicated that only patients with type II epithelial ovarian cancer (SMR=2.31; 95% CI [1.83-2.91]) had an increased risk of suicide, and those with type I and type II epithelial ovarian cancer (SMR=1.65; 95% CI [1.39-1.97] and SMR=1.49; 95% CI [1.30-1.70]) were at a higher risk of accidental death. Patients with ovarian cancer who were younger, white, diagnosed with high-grade, non-metastatic cancer and pelvic exenteration were at a higher risk of suicide. Additionally, pelvic exenteration increased the risk of suicide but not the risk of accidental death among these women. Conclusion Women with ovarian cancer had a higher risk of suicide and accidental death compared with the general population. Clinicians should identify high-risk subgroups of ovarian cancer patients for suicide and accidental death as early as possible, with appropriate prevention strategies.

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“…Mahdi et al reported the highest suicide rates within the first year following diagnosis among women with gynecologic cancer, with an SMR of 2.8 ( 8 ). Further, prior research has shown that significantly higher risks of suicide were observed among patients diagnosed with breast cancer ( 19 ), brain cancer ( 20 ), male genital-system ( 21 ), and skin malignant melanoma ( 22 ) within the first year of diagnosis. We thought it reasonable as the change from being a healthy individual to being a cancer patient who had a poor prognosis created a new perception of identity.…”

Section: Discussionmentioning

confidence: 99%

Suicide and Accidental Death Among Women With Primary Ovarian Cancer: A Population-Based Study

Chen

Xiong

et al. 2022

Front. Med.

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BackgroundWomen with ovarian cancer had the highest suicidal rate among all patients with gynecological malignancies, but no large studies about suicide and accidental death for women with ovarian cancers in detail were conducted. We aimed to determine the relative risk of suicide and accidental death among patients with ovarian cancer to that of the general population, and to identify risk factors associated with suicide and accidental death.MethodsData are from the SEER (surveillance, epidemiology, and end results) cancer registry of women diagnosed with ovarian cancer data from 18 registries for the years 1973–2016. The study population comprised 149,204 patients after inclusion and exclusion criteria were applied. Standardized mortality ratios (SMRs) were calculated and Fine-Gray models were fitted to identify risk factors associated with suicidal and accidental death among cancer patients, with stratifications on demographic and tumor-related characteristics.ResultsWomen with ovarian cancer had a higher risk of suicide and accidental death than the cancer-free group [SMR = 1.86; 95% CI (1.54–2.25) and SMR = 1.54; 95% CI (1.39–1.71)]. Subgroup analysis indicated that only patients with type II epithelial ovarian cancer [SMR = 2.31; 95% CI (1.83–2.91)] had an increased risk of suicide, and those with type I and type II epithelial ovarian cancer [SMR = 1.65; 95% CI (1.39–1.97) and SMR = 1.49; 95% CI (1.30–1.70)] were at a higher risk of accidental death. Patients with ovarian cancer who were younger, white, diagnosed with high-grade, non-metastatic cancer and pelvic exenteration were at a higher risk of suicide. The advanced age, earlier year of diagnosis, and non-metastatic cancer were associated with a higher risk of accidental death. Additionally, pelvic exenteration increased the risk of suicide but not the risk of accidental death among women with primary ovarian cancer.ConclusionsWomen with ovarian cancer had a higher risk of suicide and accidental death compared with the general population. The findings suggested that clinicians should identify high-risk subgroups of ovarian cancer patients for suicide and accidental death as early as possible, with appropriate prevention strategies.

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Association of Brain Cancer With Risk of Suicide

Cited by 15 publications

References 7 publications

Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study

Suicide and Accidental Death Among Women with Primary Ovarian Cancer: A population-based study

Suicide and Accidental Death Among Women With Primary Ovarian Cancer: A Population-Based Study

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