Association of breakfast consumption frequency with fasting glucose and insulin sensitivity/b cells function (HOMA-IR) in adults from high-risk families for type 2 diabetes in Europe: the Feel4Diabetes Study

Apergi, Kyriaki; Karatzi, Kalliopi; Reppas, Kyriakos; Karaglani, Eva; Usheva, Natalya; Giménez-Legarre, Natalia; Moreno, Luís A.; Dimova, Rumyana; Antal, Emese; Kivelä, Jemina; Cardon, Greet; Iotova, Violeta; Μanios, Yannis; Makrilakis, Konstantinos

doi:10.1038/s41430-022-01160-z

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Our study also showed that the consumption of breakfast is a factor in better metabolic biomarkers (Figure 4). This concurs with findings from a study of adults in families at high risk of T2DM in six European countries [54]. Another important finding of our study, as shown in the initial interviews of the patients with the dietitian, is that patients ignore the basic parameters of the disease.…”

Section: Discussionsupporting

confidence: 92%

Effectiveness of a Nutrition Education Program for Patients with Type 2 Diabetes Mellitus

Gortzi,

Dimopoulou,

Androutsos

et al. 2024

Applied Sciences

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Diabetes is a metabolic disease that is a major health problem globally. Dietary interventions contribute to the management of the disease and the improvement in patients’ quality of life. The aim of the present study was to assess the effects of a nutrition and lifestyle education intervention on a sample of patients with diabetes. The duration of the intervention was 3 months, and it focused on the promotion of the Mediterranean diet through information pamphlets, diet plans and healthy lifestyle guidelines, which were provided in addition to patients’ standard medical treatment. Patients were enrolled in the outpatient clinic of the University Hospital of Larissa (Greece). Anthropometric and biochemical parameters were recorded at baseline and follow-up using standardized equipment and methods. The intervention improved patients’ body mass index, body composition, fasting glucose, postprandial glucose, triglycerides, HDL/LDL cholesterol and cholesterol. For smoking status, alcohol consumption and physical activity categorization, physical activity improved but not the other two indices. The results of this study show that patient education should be provided according to the nutritional recommendations for T2DM plus a more individually structured intervention. It is therefore necessary to direct the attention of doctors to the need for continuous and detailed discussions with patients in relation to both the standards of a healthy diet and the benefits it brings. Patients, for their part, need to commit to following an appropriate, healthy diet.

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Section: Discussionsupporting

confidence: 92%

Effectiveness of a Nutrition Education Program for Patients with Type 2 Diabetes Mellitus

Gortzi,

Dimopoulou,

Androutsos

et al. 2024

Applied Sciences

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“…Specifically, the HOMA-IR and TyG index confirmed progressive insulin resistance in diabetic db/db mice at 28 weeks of age. Although HOMA-IR is widely utilised in clinical ( 19 , 20 ) and preclinical diabetic literature ( 3 , 21 ), TyG index is a relatively novel and inexpensive surrogate marker for insulin resistance that is positively correlated with HOMA-IR and glycated haemoglobin (HbA1c) ( 22 , 23 ). Moreover, the TyG index shows promise in identifying individuals with T2DM-associated microvascular complications ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

In vivo retinal imaging is associated with cognitive decline, blood-brain barrier disruption and neuroinflammation in type 2 diabetic mice

Majimbi,

McLenachan,

Nesbit

et al. 2023

Front. Endocrinol.

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IntroductionType 2 diabetes (T2D) is associated with chronic inflammation and neurovascular changes that lead to functional impairment and atrophy in neural-derived tissue. A reduction in retinal thickness is an early indicator of diabetic retinopathy (DR), with progressive loss of neuroglia corresponding to DR severity. The brain undergoes similar pathophysiological events as the retina, which contribute to T2D-related cognitive decline.MethodsThis study explored the relationship between retinal thinning and cognitive decline in the LepR db/db model of T2D. Diabetic db/db and non-diabetic db/+ mice aged 14 and 28 weeks underwent cognitive testing in short and long-term memory domains and in vivo retinal imaging using optical coherence tomography (OCT), followed by plasma metabolic measures and ex vivo quantification of neuroinflammation, oxidative stress and microvascular leakage.ResultsAt 28 weeks, mice exhibited retinal thinning in the ganglion cell complex and inner nuclear layer, concomitant with diabetic insulin resistance, memory deficits, increased expression of inflammation markers and cerebrovascular leakage. Interestingly, alterations in retinal thickness at both experimental timepoints were correlated with cognitive decline and elevated immune response in the brain and retina.DiscussionThese results suggest that changes in retinal thickness quantified with in vivo OCT imaging may be an indicator of diabetic cognitive dysfunction and neuroinflammation.

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“…All samples were analyzed in duplicated and run in a single assay with intra-assay and percent coefficients of variability of less than 10% for all assays. We evaluated insulin resistance by calculating the homeostasis model assessment of insulin resistance (HOMA-IR), a representative index used for evaluation of insulin resistance (Anwer et al 2008;Fukuda et al 2015;Apergi et al 2022). HOMA-IR was calculated using FBS and fasting plasma insulin concentrations according to the previous study (HOMA-IR = (FBS × plasma insulin concentration)/405) (Anwer et al 2008;Fukuda et al 2015;Apergi et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus

Hosogi

Kuwahara

et al. 2023

Biomed. Res.

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The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefural would prevent T2DM pathogenesis, we used Otsuka Long-Evans Tokushima fatty (OLETF) rats, T2DM model. Mumefural diminished hyperglycemia, HOMA-IR and plasma triglyceride concentration in OLETF rats under fasting conditions. In addition, mumefural elevated protein expression of sodium-coupled monocarboxylate transporter 1 (SMCT1) in the distal colon participating in absorption of weak organic acids, which behave as bases but not acids after absorption into the body. Mumefural also increased the interstitial fluid pH around the brain hippocampus lowered in OLETF rats compared with non-T2DM LETO rats used as control for OLETF rats. Amyloid-beta accumulation in the brain decreased in accordance with the pH elevation. On the one hand, mumefural didn't affect plasma concentrations of glucagon, GLP-1, GIP or PYY under fasting conditions. Taken together, these observations indicate that: 1) mumefural would be a useful functional food improving hyperglycemia, insulin resistance and the lowered interstitial fluid pH in T2DM; 2) the interstitial fluid pH would be one of key factors influencing the accumulation of amyloid-beta.

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Association of breakfast consumption frequency with fasting glucose and insulin sensitivity/b cells function (HOMA-IR) in adults from high-risk families for type 2 diabetes in Europe: the Feel4Diabetes Study

Cited by 6 publications

References 45 publications

Effectiveness of a Nutrition Education Program for Patients with Type 2 Diabetes Mellitus

Effectiveness of a Nutrition Education Program for Patients with Type 2 Diabetes Mellitus

In vivo retinal imaging is associated with cognitive decline, blood-brain barrier disruption and neuroinflammation in type 2 diabetic mice

Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus

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