Association of Breastfeeding for the First Six Months of Life and Autism Spectrum Disorders: A National Multi-Center Study in China

Huang, Saijun; Wang, Xin; Sun, Tao; Yu, Hong; Liao, Yanwei; Cao, Muqing; Cai, Li; Li, Xiuhong; Lin, Lizi; Su, Xi; Jin, Jing

doi:10.3390/nu14010045

Cited by 12 publications

(5 citation statements)

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“…A 2019 meta-analysis, involving >20 million individuals, reported that children delivered via C-section were ~30% more likely to be diagnosed with ASD than those born vaginally (36). At the same time, other research has indicated that toddlers without breastfeeding in the first 6 months of life have higher odds of developing ASD when compared to those who were exclusively breastfed (37). The results of the present study did not confirm these observations.…”

Section: Discussioncontrasting

confidence: 96%

Gut health of children with autism spectrum disorder

et al. 2022

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, frequently manifested by gastrointestinal symptoms. The investigation of alterations in the gut microbiome and its role in the gut-brain axis communication is a promising field that may aid in the understanding of ASD symptoms. The present study thus focused on a preliminary investigation of the diversity, presence and drug-resistance of particular bacterial species in the gut microbiota of ASD and neurotypical children. The study was performed in a case-control manner and the relevant information of the participants was collected using dedicated questionnaires. Stool samples were collected from urban residents and the differences in microbial communities between the study and control groups were investigated and compared using culture-dependent methods. Since phages are considered as alternatives to antibiotics, as well as a promising tool for the re-instatement of disturbed microbiotas, antibiotic resistance and phage susceptibility profiles of the isolated intestinal pathogens were defined simultaneously. As a result, antibiotic resistant and phage susceptible β-haemolytic Escherichia coli, but no Clostridioides difficile were detected in the collected sample. The differences in intestinal health and gut microbiota between the study groups were minor. On the whole, the findings of the present study may provide the basis for an extended metagenomics study of microbiota in the ASD population.

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Section: Discussioncontrasting

confidence: 96%

Gut health of children with autism spectrum disorder

et al. 2022

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“…In concordance with our data, there may be a link between the elevated risk of ASD and a family history of neurological and mental illnesses (26) . Hereditary or psychological variables may be responsible for this (27) . However, in this study, there was little to no correlation between having a good family history and any of the socioeconomic strata.…”

Section: Discussionmentioning

confidence: 99%

Socio-economic Status in Egyptian Patients with Autism Spectrum Disorder. Does it affect Autism Severity?

Zahra¹,

Mahmoud²,

Lateef³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Socioeconomic status (SES) exerts a crucial impact on the prevalence of chronic non-communicable diseases worldwide. The objective of the current study is to assess the SES in children with autism spectrum disorder (ASD) and its relation to clinical characteristics and disease severity. Patients and methods: This was a cohort including 200 children diagnosed with ASD, using the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria. Severity was assessed using the Childhood Autism Rating Scale (CARS). SES was determined using the scoring system for measurement of socioeconomic status (SES) in health research in Egypt which was originally developed by Fahmy and El Sherbini in 1983 and then updated by El -Gilany in 2012. Results: In the studied patients, 57% of the children with ASD belonged to the middle SES group, compared to 21% and 22% in the low and high SES groups, respectively. Children with lower SES scores were more likely to experience a delayed diagnosis (p = 0.016). Those with higher SES scores fared better, with lower CARS scores and higher non-verbal IQ scores (P values 0.034 and 0.003, respectively). The SES and ASD severity groups differed in a few ways, but the values did not reach statistical significance level. Conclusion: Targeting certain socioeconomic and demographic factors involved in autism could help to implement tailored preventive and management strategies.

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“…However, many previous studies, have reported lower rates in children with ASD. 16,17,27 In a case -control study of Indian children from 2-6 years, George et al reported breast feeding duration under 6 months in those with ASD. 28 Another case control study of siblings from India conducted by Manohar et al found that children with ASD were sub optimally breastfed, compared to their neurotypical siblings.…”

Section: Breastfeeding Patternsmentioning

confidence: 99%

Feeding behaviours in infancy of children later diagnosed with autism spectrum disorder

Varma

Desouza

2023

Int J Contemp Pediatr

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Background: Autism spectrum disorder, the fastest growing childhood neurodevelopmental diagnosis, shows good outcomes with early intervention. The search for behavioral early markers is an important area of research. Studies of breastfeeding and weaning behaviours in autism have reported characteristic patterns which could be early indicators of this condition. Methods: The study was a cross sectional survey of breastfeeding and weaning patterns during the first year of life in 50 children aged 15 months to 5 years, including 25 with ASD and 25 Neurotypical children. A semi-structured interview schedule and the brief assessment of mealtime behavior in children scale was used to elicit feeding history from their mothers. Data was analysed using descriptive statistics and tests of significance. Results: There were significant differences in the patterns of early feeding of children with ASD, compared to the NT children. 64% ASD children showed dysregulated vigorous sucking during breastfeeding, without knowing when to stop. 52% of them breast fed for more than 40 minutes per feed. 68% continued to breastfeed beyond the age of 2 years. A significant proportion of ASD children also showed weaning difficulties such as limited variety (40%), food refusal (36%) and disruptive mealtime behaviour (32%). Conclusions: Children with ASD show significantly more challenging breastfeeding and weaning behaviours in infancy, compared to NT children. These patterns could be identified by parents and health workers in early child development as possible early signs of ASD and prompt referral for further diagnostic evaluation.

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Association of Breastfeeding for the First Six Months of Life and Autism Spectrum Disorders: A National Multi-Center Study in China

Cited by 12 publications

References 50 publications

Gut health of children with autism spectrum disorder

Gut health of children with autism spectrum disorder

Socio-economic Status in Egyptian Patients with Autism Spectrum Disorder. Does it affect Autism Severity?

Feeding behaviours in infancy of children later diagnosed with autism spectrum disorder

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