Association of Burkitt's Lymphoma with the Epstein-Barr Virus in Two Developing Countries

Rao, Clementina Rama; Gutiérrez, Marina; Bhatia, Kishor; Fend, Falko; Franklin, Janet; Gallo, Guillermo; O’Conor, Gregory T.; Lalitha, N.; Magrath, Ian

doi:10.3109/10428190009065832

Cited by 34 publications

(27 citation statements)

References 29 publications

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“…Although the sample size was small, the findings in the present study were similar to results reported in the previous studies in Japan [Kunimoto et al, 1992;Fukayama et al, 1994;Sidagis et al, 1997]. Among EBV-associated-Burkitt's lymphoma in India, subtype A was predominant [Rao et al, 2000]. On the other hand, Rathaur et al [1999] reported a geographical variation of EBV subtypes among Indian patients with nasopharyngeal carcinoma.…”

Section: Discussionsupporting

confidence: 81%

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

Jayasree

Koriyama

Akiba

et al. 2002

Journal of Medical Virology

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Epidemiological and clinicopathological features of Epstein-Barr virus (EBV) associated gastric carcinoma was compared in India and Japan, two countries differing markedly in gastric cancer incidence. Using in situ hybridization assay, the presence of EBV-encoded small RNA (EBER) was examined in 215, and 2,011 gastric cancer cases in Kerala, India, and Japan, respectively. Ten cases (5%), all males, in the Indian series were EBER-positive. This frequency was similar to that in the Japanese series (6.2%). As was the case with Japanese series, the EBV-associated gastric carcinoma in the Indian series was observed most frequently in the middle part of the stomach (1 in antrum, 4 in middle part, 2 in cardia, and 3 unknown), and, histologically, the diffuse type Lauren's classification (8 cases) was more common than the intestinal type (2 cases). Virus subtyping by PCR-RFLP revealed that all of the 10 EBV strains isolated from the EBER-positive Indian cases were subtype A, and wild-type F for Bam HI F region. In Bam HI I region, 8 cases were type C and the remaining 2 cases were type D. In either series, there was no significant difference in the frequency of tumors with p53 overexpression between EBER-positive and -negative cases. However, the proportion of cells with p53 overexpression in EBER-negative tumors was significantly higher than that in EBER-positive tumors regardless of histological type in both series. In conclusion, the frequency and major clinicopathological features of EBV-associated gastric carcinoma in south India were similar to those observed in Japanese series although gastric cancer incidence in these two countries differs markedly.

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Section: Discussionsupporting

confidence: 81%

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

Jayasree

Koriyama

Akiba

et al. 2002

Journal of Medical Virology

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“…These results were in agreement with some previously studies which also found 30% EBV positive in their NHL cases [22], [26]. On other hand, different studies reported higher association of the EBV with NHL as high as 80% in other developing countries [27], [10]. It is also worth mentioning that Burkitt's lymphoma is a high-grade malignant NHL that is most commonly associated with EBV infection [10], [12], [22], [27].…”

Section: Resultssupporting

confidence: 82%

“…On other hand, different studies reported higher association of the EBV with NHL as high as 80% in other developing countries [27], [10]. It is also worth mentioning that Burkitt's lymphoma is a high-grade malignant NHL that is most commonly associated with EBV infection [10], [12], [22], [27]. Furthermore, in Africa, Burkitt's lymphoma is associated with Plasmodium falciparum malaria, and tumors usually present in the jaw, over 90 percent of these cases are associated with EBV.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Epstein-Barr Virus Latent Membrane Protein-1 in Jordanian Patients with Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma

Irshaid¹,

Jaran²,

Dilmi³

et al. 2010

J. of Biological Sciences

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Abstract-The aim of this study was to estimate the frequency of EBV infection in Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) occurring in Jordanian patients. A total of 55 patients with lymphoma were examined in this study. Of 55 patients, 30 and 25 were diagnosed as HL and NHL, respectively. The four HL subtypes were observed with the majority of the cases exhibited the mixed cellularity (MC) subtype followed by the nodular sclerosis (NS). The high grade was found to be the commonest subtype of NHL in our sample, followed by the low grade. The presence of EBV virus was detected by immunostating for expression of latent membrane protein-1 (LMP-1). The frequency of LMP-1 expression occurred more frequent in patients with HL (60.0%) than in patients with NHL (32.0%). The frequency of LMP-1 expression was also higher in patients with MC subtype (61.11%) than those patients with NS (28.57%). No age or gender difference in occurrence of EBV infection was observed among patient with HL. By contrast, the prevalence of EBV infection in NHL patients aged below 50 was lower (16.66%) than in NHL patients aged 50 or above (46.15%). In addition, EBV infection was more frequent in females with NHL (38.46%) than in male with NHL (25%). In NHL cases, the frequency of EBV infection in intermediate grade (60.0%) was high when compared with frequency of low (25%) or high grades (25%).In conclusion, analysis of LMP-1 expression indicates an important role for this viral oncogene in the pathogenesis of EBV-associated malignant lymphomas. These data also support the previous findings that people with EBV may develop lymphoma and that efforts to maintain low lymphoma should be considered for people with EBV infection.

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“…Differences in cancer incidence rates between HIC and many LIC have been documented for childhood cancer as a whole, [5][6][7] and for a variety of specific cancers, including Burkitt and Hodgkin lymphomas, [8][9][10] adrenocortical carcinoma, 11,12 and acute lymphoblastic leukemia (ALL), the most common childhood cancer worldwide. International variation in the incidence of ALL is well recognized.…”

Section: Sources and Quality Of Childhood Cancer Epidemiology Datamentioning

confidence: 99%

Childhood cancer epidemiology in low‐income countries

Howard

Metzger

Wilimas

et al. 2007

Cancer

240

183

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Global studies of childhood cancer provide clues to cancer etiology, facilitate prevention and early diagnosis, identify biologic differences, improve survival rates in low-income countries (LIC) by facilitating quality improvement initiatives, and improve outcomes in high-income countries (HIC) through studies of tumor biology and collaborative clinical trials. Incidence rates of cancer differ between various ethnic groups within a single country and between various countries with similar ethnic compositions. Such differences may be the result of genetic predisposition, early or delayed exposure to infectious diseases, and other environmental factors. The reported incidence of childhood leukemia is lower in LIC than in more prosperous countries. Registration of childhood leukemia requires recognition of symptoms, rapid access to primary and tertiary medical care (a pediatric cancer unit), a correct diagnosis, and a data management infrastructure. In LIC, where these services are lacking, some children with leukemia may die before diagnosis and registration. In this environment, epidemiologic studies would seem to be an unaffordable luxury, but in reality represent a key element for progress. Hospital-based registries are both feasible and essential in LIC, and can be developed using available training programs for data managers and the free online Pediatric Oncology Networked Data Base (www.POND4kids.org), which allows collection, analysis, and sharing of data.

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Association of Burkitt's Lymphoma with the Epstein-Barr Virus in Two Developing Countries

Cited by 34 publications

References 29 publications

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

Epstein‐Barr virus‐associated gastric carcinoma in southern India: A comparison with a large‐scale Japanese series

Prevalence of Epstein-Barr Virus Latent Membrane Protein-1 in Jordanian Patients with Hodgkin’s Lymphoma and Non-Hodgkin’s Lymphoma

Childhood cancer epidemiology in low‐income countries

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