Association of C-Reactive Protein with the Presence and Extent of Angiographically Verified Coronary Artery Disease

Abstract

Prospective studies have demonstrated that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP) and fibrinogen, predict future cardiovascular disease risk. However, the association between the hsCRP and fibrinogen levels and the extent of coronary stenosis in patients with coronary artery disease (CAD) remains controversial. The aim of our casecontrol study was to assess the association of inflammatory markers with the occurrence and extent of CAD. Serum hsCRP and plasma fibrinogen levels were measured in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed ( 50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease. The hsCRP and fibrinogen levels were significantly higher in patients than in controls ( p < 0.001). Although the hsCRP and fibrinogen levels tended to increase with the number of stenotic vessels, the differences were only significant for hsCRP ( p < 0.01). Regression analysis indicated hsCRP as an independent predictor for the presence (OR = 3.573, p < 0.05) and extent of CAD (β = 1.095, p < 0.05). In conclusion, the present study is the first report concerning the frequency distribution of hsCRP in Serbian healthy subjects and CAD patients. We have shown that elevated levels of hsCRP are associated with the presence and extent of CAD.atherosclerosis; inflammation; fibrinogen; hsCRP; coronary artery disease

Association between High-Sensitivity C-Reactive Protein and Left Ventricular Diastolic Function Assessed by Echocardiography in Patients with Cardiovascular Risk Factors

“…However, previous studies focused on the effects of CRP on atherosclerosis and ischemic heart disease (Memon et al 2006;Eyileten et al 2007). There are some data regarding the relationships between hsCRP and echocardiographic parameters, which can assess the risks of cardiovascular events in patients with cardiovascular risk factors, including hypertension, diabetes, and dyslipidemia (deFilippi et al 2003;Conen et al 2006).…”

Impact of the Inflammatory and Ischemic Heart Disease Markers Into the Overall Cardiovascular Mortality in Senile Citizens of a Large City (The Data From Sahr Trial)

“…В исследовании PHS (The Physician's Health Study) у лиц без ССЗ и низким процентом курящих, пока-зали, что с высшим базовым уровнем вчСРБ, риск мозгового инсульта (МИ) в 2 раза выше, ИМ в 3 раза, а периферического атеросклероза -в 4 раза. Memon L., Spasojevic-Kalimanovska V., et al показали, что коро-нарный стеноз был более выражен, чем выше был уровень вчСРБ, риск ИМ возрастал прямо пропорцио-нально увеличению базового уровня вчСРБ [15]. В исследовании CARE (Cholesterol And Recurrent Events), включавшем более 700 пациентов с острым ИМ, показано, что у лиц с высоким содержанием вчСРБ (верхний квинтиль >6,6 мг/л) ОР развития повторных коронарных событий был на 75% выше, чем у пациентов с его низким уровнем (нижний квин-тиль <1,2 мг/л) [16], а снижение ХС-ЛПНП ниже уровня 3,2 ммоль/л не влекло за собой дальнейшего снижения смертности [17].…”

Biomarkers and Coronary Atherosclerotic Burden and Activity as Assessed by Coronary Angiography and Intra-Coronary Imaging Modalities

“…However, no association between fibrinogen levels and any of the coronary scores applied was found. Finally, Memon et al (Memon et al, 2006) measured plasma fibrinogen levels in 138 patients with angiographically assessed CAD and in 183 healthy subjects matched according to age and gender. According to the number of significantly stenosed (>or=50%) vessels, the patients were classified in four groups: those without stenosis (0-vessel disease) and those with 1, 2 or 3-vessel disease.…”