Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus, and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study

Abstract

This study was undertaken to assess the associations of C-reactive protein (CRP) with incident type-2 diabetes mellitus (T2DM) and to determine the joint effect of obesity and hypertension on them in the large-scale population-based Korean cohort of the Korean Genome and Epidemiology study (KoGES). We included 22,946 men and women from 11 rural communities at baseline (2005–2011). Epidemiological data and blood samples were collected. Incident physician-diagnosed T2DM cases (130 men and 148 women) were self-reported or based on fasting glucose ≥126 mg/dL or HbA1c level ≥6.5% during a median follow-up of 3.0 years (58,916 person-years) between 2007 and 2014. After multivariate adjustment for T2DM risk factors, the hazard ratios for developing T2DM in the highest CRP tertile (T3), compared with the lowest (T1), was 2.80 (1.73–4.52; p for trend <0.0001) in women and 1.67 (1.00–2.45; p for trend 0.02) in men. The associations between CRP and incident T2DM were more prominent among the older group (≥50 years). And CRP and its combination with obesity and hypertension were associated with increased risk of T2DM. In conclusion, we found positive associations between CRP and incident T2DM in a large population-based Korean cohort.

High Sensitivity C-reactive Protein Concentrations, Lipid Status And Duration Of Type-1 Diabetes

“…Hs-CRP concentrations increased with prolonged duration of diabetes in our study which is in line with the studies of [2,3,5,9,10,11] which reported a relationship between duration of diabetes, increased hs-CRP concentrations and resultant chronic inflammation. However, Wong et al, 2010 found a correlation between Hs-CRP levels and DOD in females only.…”

“…Lipid profile among patients was within normal limits in our study. We observed a positive correlation between hs-CRP concentrations, triglycerides, TC and LDL-C as reported in studies [10][11][12][13][14]. This may be linked to the established association between systemic inflammation and lipid status in patients with diabetes and the fact that none of the patients recruited for our study was taking oral antihypertensive medication which is known to be associated with lower risk of obtaining elevated hs- Body mass index correlated positively with age, systolic blood pressure, diastolic blood pressure and waist circumference.…”

“…This may be linked to the established association between systemic inflammation and lipid status in patients with diabetes and the fact that none of the patients recruited for our study was taking oral antihypertensive medication which is known to be associated with lower risk of obtaining elevated hs- Body mass index correlated positively with age, systolic blood pressure, diastolic blood pressure and waist circumference. Our study showed increased BMI among patients which is similar to [2,10,11,13,14,20] but contrary to the findings of [6]. Our study also observed that BMI and WC were elevated in females compared to males which are contrary to the reports of [12,15].…”

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

“…The findings of this study are in aggrement with other studies. Gambineri and Pelusi [30] reported that inflammation associated with T2D is more prominent in diabetic women due to hyperandrogenism which contributes to abdominal obesity; insulin sensitivity which influences the finding is accordance with Kanmani et al, [29] that reported higher level of CRP in women due to excess adiposity. Also elevated level was reported by Svensson et al, [26] in female type 2 diabetics.…”

“…Also, Cardoso et al, [28] showed higher CRP which was significantly associated with younger age less than eighty years. Kanmani et al, [29] reported that the association between C-reactive protein and incidence of type 2 diabetes mellitus which is more prominent among subjects from fifty years due to severe inflammation. The current study found gender difference in the level of C-reactive protein.…”