Association of cadmium and arsenic exposure with salivary telomere length in adolescents in Terai, Nepal

Fillman, Toki; Shimizu-Furusawa, Hana; Ng, Chris Fook Sheng; Parajuli, Rajendra Prasad; Watanabe, Chiho

doi:10.1016/j.envres.2016.04.037

Cited by 47 publications

(32 citation statements)

References 70 publications

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“…In comparison with the previous reports, the urinary arsenic concentration among the Myanmar population was much lower than those in the Argentinian population (median = 230 μg/L), the Bangladesh population (mean = 336.7 μg/L), the Nepalese population (mean = 196 μg/g creatinine) and the Indian population (mean = 290 μg/L) [ 36 , 37 , 38 , 39 ]. In the case of cadmium, the urinary cadmium concentration in this study (geometric mean (GM) = 0.87 μg/g creatinine) was comparatively higher than in the previous findings on those from Bangladesh (median = 0.63 μg/g creatinine), the United States (mean = 0.46 μg/g creatinine), Nepal (GM = 0.33 μg/g creatinine), China (GM = 0.55 μg/g creatinine) and South Africa (GM = 0.27 μg/g creatinine) [ 17 , 19 , 38 , 40 , 41 ]. The median selenium concentration of this study was lower than 30 μg/g creatinine and was similar to the concentration of the normal reference range [ 42 ].…”

Section: Discussioncontrasting

confidence: 74%

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Wai

Mar

Kosaka

et al. 2017

IJERPH

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Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01–1.21; p = 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72–0.95; p = 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31–13.65; p = 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.

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Section: Discussioncontrasting

confidence: 74%

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Wai

Mar

Kosaka

et al. 2017

IJERPH

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“…14,15 Whereas a few published studies of the association between arsenic exposure and telomere length (TL) tend to be small, recent epidemiologic studies linked arsenic exposure to longer TL in peripheral blood and saliva and altered peripheral blood expression of genes involved in telomere maintenance. 10,[18][19][20][21][22] This study examined the effects of as exposure on hTERT mRNA levels in blood cells from CVD patients exposed to a varied range of As. In this study, Asexposed patients group showed approx.…”

Section: Discussionmentioning

confidence: 99%

Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Khaleda

Forkan

Wali

et al. 2019

Bangladesh Med Res Counc Bull

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Background: Exposure to inorganic arsenic (iAs) through drinking water is currently a serious threat to public health of millions of people worldwide including Bangladesh. Some recent studies have shown that telomere dysfunction is emerging as an important factor in the pathogenesis of different cardiovascular diseases. Arsenic plays significant role on telomere dysfunction by altering the expression of telomere-related genes. The study was aimed to investigate the effects of arsenic on hTERT mRNA levels and their combined role in increasing CVD susceptibility. Methods: In this cross sectional study, total of 50 CVD patients who underwent open heart surgery were recruited for this study. Urine, nail and cardiac tissue samples were collected and analyzed for As. Blood samples were quantified for hTERT expression analysis using real-time polymerase chain reaction. Results: The hTERT mRNA expression was found approx. 10 fold higher in the As-exposed patients than the As-unexposed patients (p<0.01). A strong positive correlation (p<0.01, R>0.3) was found between the hTERT mRNA levels and As contents in the cardiac tissue, nail and urine samples of the study subjects. The significant increase (approx. 4 fold) in the hTERT mRNA expression was found in the patients with coronary artery disease (CAD) than the non-CAD patients. Conclusions: The results of the study suggest that arsenic exposure increases hTERT mRNA expression which may in turn modify As-induced cardiovascular outcomes. The findings of this study will help to look deep into the association of As exposure in cardiovascular disease pathogenesis to open a new window in the diagnosis and treatment procedure of CVD. Bangladesh Med Res Counc Bull 2019; 45: 03-10

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“…The authors observed that pollution from illegal waste sites was significantly associated with shorter telomere length, higher oxidative stress levels, and lower telomerase activity, which are known factors of cellular senescence and aging-related meiotic dysfunction in women [102]. Even low levels of cadmium shortened buccal cell telomere length in adolescents environmentally exposed to this metal [103]. Arsenic exposure to drinking water increased telomere length in individuals from West Bengal, India.…”

Section: Occupational and Environmental Exposuresmentioning

confidence: 89%

“…Yet, most studies with regard to telomere length in children are conducted on the effects of environmental exposure and socioeconomic and psychological status [72,73,98,99,101,103]. A recently published study analyzed whether nutritional factors are associated with telomere length in children [112].…”

Section: What Can Be Done To Help Maintain Telomere Length?mentioning

confidence: 99%

Telomere Length and Its Relation to Human Health

Kahl¹,

Silva²

2016

Telomere - A Complex End of a Chromosome

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Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwanted recombination-fusion, inappropriate activation of DNA damage response and play a critical role in cell division and chromosome stability. There is growing evidence that telomere stability can be affected by occupational and environmental exposure, as some of these factors have been correlated with increase in inflammation, oxidative stress, DNA damage, chromosome aberration, and epigenetic alterations. Both extremely short and long telomeres have been associated with neurodegenerative, cardiovascular diseases (CVD) and cancer risk. Occupational and environmental exposure to several synthetic and natural chemicals has been found to be associated with changes in telomere length, although the molecular mechanism is not fully understood. Telomeric DNA is relatively less capable of repair, resulting in accelerated shortening during the cell cycle and replicative senescence. It is recognized that diet plays an important role in telomere maintenance. Prevention of exposure to environmental and occupational hazards as well as psychological stressors can reduce the risk of telomere instability. This review provides a broad evaluation of the associated mechanism between human health and environmental and occupational exposure with telomere length, including recent findings and future perspectives.

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Association of cadmium and arsenic exposure with salivary telomere length in adolescents in Terai, Nepal

Cited by 47 publications

References 70 publications

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Telomere Length and Its Relation to Human Health

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