Association of caffeine intake and histological features of chronic hepatitis C

25 years of Hepatitis C

“…We drew attention fact that the amount of caffeine necessary to reduce the degree of fibrosis was significantly lower than in English literature (125 mg or only 4 Brazilian cups of coffee versus 250 mg or 308 mg daily). This difference can be attributed to several factors but interestingly, in our population coffee represented more than 90% of the daily caffeine intake, while in other studies a large contingent of caffeine derived from soft drinks and processed juices (12,14,22) . The study of Oliveira et al confirms our findings of the relationship between lower grade of fibrosis and the ingestion of higher doses of caffeine, although this association was not find in multivariate analysis.…”

“…It has long been aware of the beneficial effects of coffee on serum liver enzymes and the alcoholic liver disease, but since 2009 several studies have shown that caffeine intake, especially in the form of coffee, has a protective effect on the development of hepatitis C virus (12,14,21,22) . In our previously published study (21) , we observed a reduction in liver fibrosis in patients taking higher doses of caffeine in univariate and multivariate analysis when compared to patients with lower daily intake of caffeine, but did not observe a relationship between caffeine with inflammatory activity in liver biopsy.…”

Effects of caffeine consumption in patients with chronic hepatitis C: A systematic review and meta-analysis

“…Thirty articles underwent full-length review, of which 19 articles were excluded because they were not related to hepatitis C (12 articles), did not have controls or comparison of high versus low caffeine intake (5 articles), was a letter to the editor (1 article), or was an abstract (1 article). Eleven studies were included in the qualitative analysis [16][17][18][19][20][21][22][23][24][25][26], and five studies were included in the meta-analysis [17,[21][22][23][24]. Fig.…”

Insulin resistance and chronic liver disease

“…In various studies including a large prospective study, patients with HCV-related liver disease with a regular coffee consumption show a lower rate of disease progression such as hepatic fibrosis [131][132][133] and HCC [134][135][136][137][138] . Recently, it was also reported that more than 3 cups per day coffee drinkers are three times more likely to have a virological response to peginterferon plus ribavirin treatment than non-drinkers [139] .…”