Association of CagA+ Helicobacter pylori infection with aortic atheroma

Shmuely, Haim; Passaro, Douglas J.; Vaturi, Mordechai; Sagie, Alex; Pitlik, Silvio; Samra, Zmira; Niv, Yaron; Koren, Rivka; Harell, Daniella; Yahav, Jacob

doi:10.1016/j.atherosclerosis.2004.09.010

Cited by 30 publications

(20 citation statements)

References 26 publications

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“…Although a more extensive aortic atherosclerotic disease has been recently associated with CagA-positive H. pylori infection [6], whether this may also happen in coronary arteries has never been studied. To clarify this issue we have evaluated the association between anti-CagA antibody titer and coronary atherosclerosis in a consecutive series of anginal patients undergoing coronary angiography.…”

Section: Introductionmentioning

confidence: 99%

Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori

Niccoli¹,

Franceschi²,

Cosentino³

et al. 2010

Coronary Artery Disease

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Section: Introductionmentioning

confidence: 99%

Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori

Niccoli¹,

Franceschi²,

Cosentino³

et al. 2010

Coronary Artery Disease

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“…An increased prevalence of these strains have previously been found in several other extragastroduodenal pathologies, characterized by activation of inflammatory mediators (i.e. ischemic heart disease, rosacea) [29, 30]. According to our results, both anti- H. pylori and anti-CagA seropositivity were significantly higher in patients than in control subjects, whereas no statistically significant difference, as regards the spirometric values, was detected between H. pylori -infected COPD patients and uninfected ones [31].…”

Section: H Pylori Infection and Copdmentioning

confidence: 99%

Respiratory Diseases and <i>Helicobacter pylori</i> Infection: Is There a Link?

Roussos

Philippou²,

Mantzaris³

et al. 2006

Respiration

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Recent studies suggest an epidemiological association between Helicobacter pylori infection and several extragastroduodenal pathologies, including cardiovascular, rheumatic, skin and liver diseases. The observed associations might be explained by a role of H. pylori infection in the pathogenesis of certain extradigestive disorders, as a variety of inflammatory mediators are activated by H. pylori infection. The present review summarizes the current literature, including our own studies, concerning the association between respiratory diseases and H. pylori infection. A small number of epidemiological and serologic case-control studies suggest that patients with chronic obstructive pulmonary disease have an increased seroprevalence of H. pylori. A frequent coexistence of bronchiectasis and H. pylori infection has also been found. Moreover, recent studies have shown an increased prevalence of H. pylori infection in patients with pulmonary tuberculosis and in those with lung cancer. On the other hand, bronchial asthma does not seem to be related to H. pylori infection. At present, there is no definite proof of a causal relationship between H. pylori and respiratory diseases. The primary evidence rests on case-control studies, concerning relatively small numbers of patients. Future studies should be large enough for moderate-sized effects to be assessed or registered reliably. The activation of inflammatory mediators by H. pylori infection might be the pathogenetic mechanism underlying the observed associations. Therefore, the role of genetic predisposition of the infected host, the presence of strain-specific virulence factors and the serum concentration of proinflammatory markers in H. pylori-infected patients with respiratory diseases need further evaluation.

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“…Of note among the observational studies are one cohort study [13], one extremely large cross-sectional study [14], and one moderately-sized cross-sectional study that controlled for H. pylori risk factors [15]. Corrado et al [13] followed 668 patients in early stages of atherosclerosis for 5 years and found that baseline seropositivity for H. pylori cytotoxin-associated gene protein (CagA) was associated with increased risk of serious cardiovascular events, controlling for cardiovascular disease risk factors but not socioeconomic status or other H. pylori risk factors.…”

Section: Atherosclerosismentioning

confidence: 99%

“…Sung et al [14] studied 58,891 adult Koreans participating in a health screening program and reported that H. pylori seropositivity was positively associated with several biomarkers linked to cardiovascular disease risk after adjusting for age; although there were no data on socioeconomic status, health screening was restricted to individuals who could afford the relatively high cost. Shmuely et al [15] studied 188 patients undergoing transesophageal echocardiography for detection of aortic plaques and found seropositivity for H. pylori CagA to be strongly associated with the presence of aortic plaques after adjustment for cardiovascular risk factors, socioeconomic status, and other H. pylori risk factors.…”

Section: Atherosclerosismentioning

confidence: 99%

Extragastric diseases associated with Helicobacter pylori infection

Goodman

Joyce²,

Ismond³

2006

Curr Gastroenterol Rep

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This paper critically reviews the current literature on extragastric diseases associated with Helicobacter pylori infection, with an emphasis on methodologic issues that complicate interpretation of study findings. This review reveals common study limitations and overall uncertainty that H. pylori infection plays a role in extragastric diseases, although such a role has not been clearly ruled out for specific diseases of relevance. Evidence suggests that anti-H. pylori therapy may lead to improvement of a few extragastric diseases, in particular, idiopathic thrombocytopenic purpura, iron deficiency anemia, and chronic idiopathic urticaria, but the data from randomized controlled trials are insufficient to confirm this beneficial effect; if the benefit of anti-H. pylori therapy for specific diseases is real, it is not clear if it results from removing H. pylori-specific injurious effects, eliminating some other infectious pathogen, or reducing the total infectious burden.

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Association of CagA+ Helicobacter pylori infection with aortic atheroma

Cited by 30 publications

References 26 publications

Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori

Coronary atherosclerotic burden in patients with infection by CagA-positive strains of Helicobacter pylori

Respiratory Diseases and <i>Helicobacter pylori</i> Infection: Is There a Link?

Extragastric diseases associated with Helicobacter pylori infection

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