2022
DOI: 10.1155/2022/6078881
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Association of Calcium and Phosphate Levels with Incident Chronic Kidney Disease in Patients with Hypoparathyroidism: A Retrospective Case-Control Study

Abstract: Objective. Reasons for the increased incidence of chronic kidney disease (CKD) in patients with chronic hypoparathyroidism are poorly understood. This study evaluated associations between levels of albumin-corrected serum calcium, serum phosphate, and calcium-phosphate product and the odds of CKD development in patients with chronic hypoparathyroidism. Design. A retrospective nested case-control study of adult patients with chronic hypoparathyroidism who had ≥1 prescription for calcitriol who developed CKD and… Show more

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Cited by 4 publications
(2 citation statements)
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“…The mechanisms underlying the increased risk of renal complications in chronic hypoparathyroidism are not definitively established. They are hypothesized to develop in part as a result of the chronically elevated serum phosphate levels, high calcium × phosphate product, serum calcium fluctuations, and hypercalciuria which are characteristic of chronic hypoparathyroidism managed with conventional therapy with long-term use of active vitamin D and elemental calcium [ 1 , 3 , 5 ]. Though conventional therapy for hypoparathyroidism aims to alleviate hypocalcemia, it does not address the consequences of chronic PTH insufficiency [ 12 ] and carries its own iatrogenic risks—such as renal injury.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The mechanisms underlying the increased risk of renal complications in chronic hypoparathyroidism are not definitively established. They are hypothesized to develop in part as a result of the chronically elevated serum phosphate levels, high calcium × phosphate product, serum calcium fluctuations, and hypercalciuria which are characteristic of chronic hypoparathyroidism managed with conventional therapy with long-term use of active vitamin D and elemental calcium [ 1 , 3 , 5 ]. Though conventional therapy for hypoparathyroidism aims to alleviate hypocalcemia, it does not address the consequences of chronic PTH insufficiency [ 12 ] and carries its own iatrogenic risks—such as renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…While the exact mechanisms responsible for this increased risk of renal complications in chronic hypoparathyroidism are not fully understood, they are hypothesized to develop in part as a result of the chronically elevated serum phosphate levels, high calcium × phosphate product, serum calcium fluctuations, and hypercalciuria which are characteristic of chronic hypoparathyroidism managed with conventional therapy with long-term use of active vitamin D and elemental calcium [ 1 , 3 , 5 ]. Therefore, treatments that replace the physiologic effects of PTH and minimize or remove the need for conventional therapy may provide beneficial effects on renal outcomes in the setting of chronic hypoparathyroidism.…”
Section: Introductionmentioning
confidence: 99%