Association of Calcium and Phosphate Balance, Vitamin D, PTH, and Calcitonin in Patients With Adolescent Idiopathic Scoliosis

Goździalska, Anna; Jaśkiewicz, Jerzy; Knapik-Czajka, Małgorzata; Drąg, Jagoda; Gawlik, Maciej; Cieśla, Maciej; Kulis, Aleksandra; Zarzycki, Daniel; Lipik, Ewa

doi:10.1097/brs.0000000000001286

Cited by 45 publications

(64 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is a multifactorial disease with uncertain primary etiology and pathogenesis [24]. The potential role of Vitamin-D in the developing adolescent scoliosis is recently being considered [25], [26]. The results of the present study provide adequate evidence of a positive relation between VDD (<25 nmol/L) and clinically detected scoliosis in adolescents.…”

Section: Discussionsupporting

confidence: 55%

Vitamin D Deficiency and Clinically Detected Scoliosis among Male Adolescents at High-Altitude Area in Southwestern Saudi Arabia

Assiri

Mahfouz

Awadalla

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES: Reports suggest that Vitamin D deficiency (VDD) is common and is a general health challenge worldwide and at high altitude in particular. AIM: The objectives were to explore Vitamin D status, to examine the association of VDD and clinically detected scoliosis, and to find a cutoff point of Vitamin D level predicting clinical scoliosis in Abha City (high-altitude area). METHODS: A nested case–control design was conducted among a screened population of 417 male adolescents from intermediate and secondary schools in Abha City, Southwest Saudi Arabia. From the surveyed adolescents, 62 cases with clinically detected scoliosis and 205 age-matched controls without scoliosis were selected. For both groups, serum level of 25-hydroxyvitamin D was assessed by standardized technique. RESULTS: More than two-thirds (68.5%) of male adolescents suffered from VDD (<25 nmol/L). The risk of clinical scoliosis was significantly higher among adolescents with VDD compared to those without deficiency (grade adjusted odds ratio = 6.88, 95% CI: 2.63–17.99). Receiver operating characteristic curve analysis showed acceptable discriminative ability of serum Vitamin D (area under the curve = 0.702) to predict scoliosis at a threshold value of ≤20.2 nmol/L. CONCLUSIONS: Overall levels of Vitamin D in the study adolescents suggest a high prevalence of VDD at high-altitude area in Southwest Saudi Arabia. There is evidence for a positive association between VDD and clinically detected scoliosis. A threshold cutoff value of 20.2 nmol/L has been identified to predict clinically detected scoliosis. The role of possible preventive effect of Vitamin D supplementation should be considered by school health authorities.

show abstract

Section: Discussionsupporting

confidence: 55%

Vitamin D Deficiency and Clinically Detected Scoliosis among Male Adolescents at High-Altitude Area in Southwestern Saudi Arabia

Assiri

Mahfouz

Awadalla

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…Vitamin D is a major factor involved in the bone growth; if deficient during first years of life, it is associated with poor skeletal mineralization, leading to a wide variety of skeletal deformities. While some studies have reported that vitamin D deficiency is frequent in patients with AIS, the modality by which vitamin D influences scoliosis is not established [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Căţan

Cerbu

Amăricăi

et al. 2020

IJERPH

View full text Add to dashboard Cite

(1) Background: Adolescent idiopathic scoliosis (AIS) can be associated with vitamin D deficiency and osteopenia. Plantar pressure and stabilometry offer important information about posture. The objectives of our study were to compare static plantar pressure and stabilometric parameters, serum 25-OH-vitamin D3 and calcium levels, and bone mineral densitometry expressed as z-score in patients with moderate AIS and healthy subjects. (2) Methods: 32 female adolescents (idiopathic S shaped moderate scoliosis, main lumbar curve) and 32 gender and age-matched controls performed: static plantar pressure, stabilometry, serum 25-OH-vitamin D3 and calcium levels, and dual X-ray absorptiometry scans of the spine. (3) Results: In scoliosis patients, significant differences were recorded between right and left foot for total foot, first and fifth metatarsal, and heel loadings. Stabilometry showed a poorer postural control when compared to healthy subjects (p < 0.001). Patients had significantly lower vitamin D, calcium levels, and z-scores. Lumbar Cobb angle was significantly correlated with the z-score (r = −0.39, p = 0.02), with right foot fifth metatarsal load (r = −0.35, p = 0.04), center of pressure CoPx (r = −0.42, p = 0.01), CoP displacement (r = 0.35, p = 0.04) and 90% confidence ellipse area (r = −0.38, p = 0.03). (4) Conclusions: In our study including female adolescents with idiopathic S shaped moderate scoliosis, plantar pressure and stabilometric parameters were influenced by the main scoliotic curve.

show abstract

“…In most of such cases, the fractured bones are pieced together in their native format and incubated at fairly warm temperatures (40-50°) after wrapping with plants leaves such as wild Ocimum gratissimum [26,31] such fractures often healed up after few days (7-21 days). Further studies on this traditional method of fixing fractures using broken/fractured chicken legs have confirmed the possible efficacy of this method in the local treatment of fractures [27,32]. Although, most of these methodologies are empirical, the possibility of enhanced osteoblastic activity due to increased vitamin D supplementation from the leaves cannot be totally ruled out.…”

Section: Fixing Of Fracturesmentioning

confidence: 96%

Plant Sources of Vitamin D and Its Medicinal Application in Sub-Sahara Africa

Omotosho¹

2019

Fads and Facts About Vitamin D

View full text Add to dashboard Cite

Vitamin D is one of the fat-soluble vitamins structurally derived from cholesterol and similar to the reproductive hormones by possessing the ABCD hexagonal rings. Its open seco-B triene B ring along with the possession of 1,25 dihydroxycholesterol side chain has been postulated as possible configuration allowing for its flexibility to interact with many tissues including bones causing myriads of biological effects that are medicinally beneficial. Aside from the established role of vitamin D in bone and mineral metabolic diseases, exploiting this property of the vitamin had been in practice in orthodox medical practice and even in traditional sub-Sahara method of managing many disease conditions.

show abstract

Association of Calcium and Phosphate Balance, Vitamin D, PTH, and Calcitonin in Patients With Adolescent Idiopathic Scoliosis

Abstract: 4.

Cited by 45 publications

References 26 publications

Vitamin D Deficiency and Clinically Detected Scoliosis among Male Adolescents at High-Altitude Area in Southwestern Saudi Arabia

Vitamin D Deficiency and Clinically Detected Scoliosis among Male Adolescents at High-Altitude Area in Southwestern Saudi Arabia

Assessment of Static Plantar Pressure, Stabilometry, Vitamin D and Bone Mineral Density in Female Adolescents with Moderate Idiopathic Scoliosis

Plant Sources of Vitamin D and Its Medicinal Application in Sub-Sahara Africa

Contact Info

Product

Resources

About