Association of cardiometabolic multimorbidity with motoric cognitive risk syndrome in older adults

Abstract

INTRODUCTIONMotoric cognitive risk syndrome (MCR) is a predementia syndrome that is characterized by cognitive complaints and slow gait. Cardiometabolic multimorbidity (CMM) is associated with an increased risk of dementia. However, the relationship between CMM and MCR is still unclear.METHODSWe included 4744 participants (aged 65+ years) without MCR at baseline from the National Health and Aging Trends Study (NHATS), who were followed‐up from 2011 to 2018. CMM was defined as the presence of two or more cardiometabolic diseases (including diabetes mellitus, heart disease, and stroke).RESULTSCMM was significantly associated with an increased risk of MCR (hazard ratio [HR] 1.41, 95% confidence interval [CI] 1.13–1.75) in fully adjusted models. Consistent results were observed from stratified analyses of different subgroups. Increasing numbers of cardiometabolic diseases were dose‐dependently associated with increased MCR risk (HR 1.33, 95% CI 1.20–1.48).DISCUSSIONCMM is associated with an increased risk of MCR in older adults.HIGHLIGHTS Motoric cognitive risk syndrome (MCR) is a predementia syndrome characterized by slow gait speed and cognitive complaints. Cardiometabolic multimorbidity was associated with an increased MCR risk. An increased number of cardiometabolic diseases were dose‐dependently associated with increased MCR risk.

Social frailty and the incidence of motoric cognitive risk syndrome in older adults

“…Sleep disorders were assessed by three questions regarding difficulty initiating sleep, difficulty falling back asleep, and sleep medication use. 30 Participants who responded “most nights or every night” on any question were defined as having sleep disorders. BMI was used to divide participants into normal or underweight (<25 kg/m 2 ), overweight (25–30 kg/m 2 ), and obese groups (>30 kg/m 2 ).…”