Association of cardiovascular health and epigenetic age acceleration

Pottinger, Tess D.; Khan, Sadiya S.; Zheng, Yinan; Zhang, Wei; Tindle, Hilary A.; Allison, Matthew; Wells, Gretchen; Shadyab, Aladdin H.; Nassir, Rami; Martin, Lisa W.; Manson, Jo Ann E.; Lloyd‐Jones, Donald M.; Greenland, Philip; Baccarelli, Andrea A.; Whitsel, Eric A.; Hou, Lifang

doi:10.1186/s13148-021-01028-2

Cited by 39 publications

(40 citation statements)

References 22 publications

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“… 26 , 27 Pottinger and his colleagues observed that poor cardiovascular health was associated with the epigenetic age acceleration in a cross‐sectional analysis of 2170 menopausal women. 28 In the present study, an increase in epigenetic age acceleration per 10–mm Hg of blood pressure was found to be <1 year. Several cardiometabolic risk factors pose threats to the premature decline of physical functioning attributable to accelerated aging, and blood pressure may play a small part in such declines.…”

Section: Discussionsupporting

confidence: 41%

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

Xiao

Zan

Liu

et al. 2022

JAHA

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Background Individuals of the same chronological age may exhibit diverse susceptibilities to death. However, few studies have investigated the associations between blood pressure and the accelerated aging. Methods and Results A cross‐sectional study was conducted in 288 adults aged ≥50 years. We assessed the DNA methylation‐based measures of biological age using CpG sites on the Illumina HumanMethylationEPIC BeadChip. Epigenetic age acceleration metrics were derived by regressing residuals (ΔAge) and ratios (aging rate) of DNA methylation age on chronological age. Dose‐response relationships between blood pressure and epigenetic age acceleration were quantified using multiple linear regression and restricted cubic regression models. We found that each 10–mm Hg increase in systolic blood pressure was associated with 0.608 (95% CI, 0.231–0.984) years increase in ΔAge and 0.007 (95% CI, 0.002–0.012) increase in aging rate; meanwhile, for pulse pressure, the increase was 1.12 (95% CI, 0.625–1.61) years for ΔAge and 0.013 (95% CI, 0.007–0.020) for aging rate. Subgroup analysis showed that the significant associations of systolic blood pressure and pulse pressure with epigenetic age acceleration appeared to be limited to women, although interactions between blood pressure and sex were not significant ( P values for interaction >0.05). The combination of women and hypertension was associated with a much higher increase in ΔAge (β [95% CI], 4.05 [1.07–7.02]) and aging rate (β [95% CI], 0.047 [0.008–0.087]), compared with male participants without hypertension. Conclusions Our findings suggested that high systolic blood pressure and pulse pressure were associated with the epigenetic age acceleration, providing important clues for relationships between blood pressure and epigenetic aging.

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Section: Discussionsupporting

confidence: 41%

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

Xiao

Zan

Liu

et al. 2022

JAHA

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“…[21,66,69] Epigenetic age may be a useful biomarker for CVD risk and provide a biological perspective on the role of epigenetic mechanisms in age-related CVD loss and CVDs. [70][71][72] GrimAge can predict CVD risk not only for White people, but also for African Americans. [73] The DNA methylation aging clock is also currently used as a biomarker for other diseases, such as stroke, Alzheimer disease, and cancer.…”

Section: Application Of Epigenetic Clocks In Cvdsmentioning

confidence: 99%

A bibliometric analysis of DNA methylation in cardiovascular diseases from 2001 to 2021

et al. 2022

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Background: DNA methylation is a dynamically reversible form of epigenetics. Dynamic regulation plays an important role in cardiovascular diseases (CVDs). However, there have been few bibliometric studies in this field. We aimed to visualize the research results and hotspots of DNA methylation in CVDs using a bibliometric analysis to provide a scientific direction for future research.Methods: Publications related to DNA methylation in CVDs from January 1, 2001, to September 15, 2021, were searched and confirmed from the Web of Science Core Collection. CiteSpace 5.7 and VOSviewer 1.6.15 were used for bibliometric and knowledge-map analyses.Results: A total of 2617 publications were included in 912 academic journals by 15,584 authors from 963 institutions from 85 countries/regions. Among them, the United States of America, China, and England were the top 3 countries contributing to the field of DNA methylation. Harvard University, Columbia University, and University of Cambridge were the top 3 contributing institutions in terms of publications and were closely linked. PLoS One was the most published and co-cited journal. Baccarelli Andrea A published the most content, while Barker DJP had the highest frequency of co-citations. The keyword cluster focused on the mechanism, methyl-containing substance, exposure/risk factor, and biomarker. In terms of research hotspots, references with strong bursts, which are still ongoing, recently included "epigenetic clock" (2017-2021), "obesity, smoking, aging, and DNA methylation" (2017-2021), and "biomarker and epigenome-wide association study" (2019)(2020)(2021).Conclusions: We used bibliometric and visual methods to identify research hotspots and trends in DNA methylation in CVDs. Epigenetic clocks, biomarkers, environmental exposure, and lifestyle may become the focus and frontier of future research.

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“…Likewise, Beach et al (2016) [28] found that childhood SES-risk was associated with widespread changes in methylation in young adulthood. Focusing more specifically on cardiometabolic health outcomes, it was reported recently that better cardiovascular health practices were associated with decreases in age acceleration on indices developed by Horvath [24] and Hannum [25], and effects were robust to calculations of intrinsic AA for both clocks [29].…”

Section: Intrinsic Dna Methylation Based Ageingmentioning

confidence: 99%

Methylation of FKBP5 is associated with accelerated DNA methylation ageing and cardiometabolic risk: replication in young-adult and middle-aged Black Americans

et al. 2021

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Methylation of FKBP5 is involved in the regulation of the stress response and is influenced by early stress exposure. Two CpG sites, cg20813374 and cg00130530, have been identified as potential reporters of early stress. We examined whether FKBP5 methylation was associated with accelerated DNA methylation ageing and indirectly predicted poorer cardiovascular health among both young adult and middle-aged Black Americans. Four hundred and forty-nine young adults, with a mean age of 28.67 and N = 469 middle-age parents and their current partners with a mean age of 57.21, provided self-reports, biometric assessments, and blood draws. Methylation values were obtained using the Illumina Epic Array. Cardiometabolic risk was calculated by summing the standardized log-transformed scores for the body mass index, mean arterial blood pressure, and HbA1c. We also used a more standard index of risk, the Framingham 10-year cardiometabolic risk index, as an alternative measure of cardiometabolic risk. To measure accelerated ageing, four widely used indices of accelerated, DNA methylation-based ageing were used controlling sex, age, other variation in FKBP5, and cell-type. Exposure to community danger was associated with demethylation of FKBP5. FKBP5 methylation was significantly associated with accelerated ageing for both young-adult and middle-aged samples, with significant indirect effects from FKBP5 methylation to cardiometabolic risk through accelerated ageing for both. Early exposure to danger may influence FKBP5 methylation. In turn, FKBP5 methylation may help explain intrinsic accelerated ageing and elevated cardiometabolic risk in adulthood for Black Americans.

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Association of cardiovascular health and epigenetic age acceleration

Cited by 39 publications

References 22 publications

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

Associations Between Blood Pressure and Accelerated DNA Methylation Aging

A bibliometric analysis of DNA methylation in cardiovascular diseases from 2001 to 2021

Methylation of FKBP5 is associated with accelerated DNA methylation ageing and cardiometabolic risk: replication in young-adult and middle-aged Black Americans

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