Association of cartilage defects, and other MRI findings with pain and function in individuals with mild–moderate radiographic hip osteoarthritis and controls

Abstract

Objective To evaluate the relationship of hip radiographic osteoarthritis (ROA) and MR findings of cartilage lesions, labral tears, bone marrow edema like lesions (BMEL) and subchondral cysts with self-reported and physical function. Design Eighty five subjects were classified as controls (n= 55, KL 0, 1) or having mild-moderate ROA (n = 30, KL 2, 3). T2-weighted MR images at 3-Tesla were graded for presence of cartilage lesions, labral tears, BMELs and subchondral cysts. Posterior wall sign, cross-over sign, center-edge angle and alpha angle were also recorded. Function was assessed using Hip Osteoarthritis Outcome Score (HOOS), Timed-Up and Go (TUG) test and Y-Balance Test (YBT). Analysis compared function between subjects with and without ROA and those with and without femoral or acetabular cartilage lesions, adjusted for age. Non-parametric correlations were used to assess the relationship between radiographic scores, MR scores and function. Results Subjects with acetabular cartilage lesions had worse HOOS (Difference = 5–10%, P = 0.036–0.004), but not TUG or YBT, scores. Acetabular cartilage lesions, BMELs and subchondral cysts were associated with worse HOOS scores (ρ= 0.23–0.37, P = 0.041–0.001). Differences in function between subjects with and without ROA or femoral cartilage lesions were not significant. Other radiologic findings were not associated with function. Conclusions Acetabular cartilage defects, but not femoral cartilage defects or ROA, were associated with greater self-reported pain and disability. BMELs and subchondral cysts were related to greater hip related self-reported pain and disability. None of the radiographic or MR features were related to physical function.

What is the prevalence of imaging-defined intra-articular hip pathologies in people with and without pain? A systematic review and meta-analysis

“…Interestingly, of the included studies that reported acetabular and femoral cartilage defects independently, a trend highlighting a greater prevalence of acetabular cartilage defects was observed in symptomatic individuals. Our finding is consistent with studies reporting associations between acetabular cartilage damage and pain, clinical symptoms and reduction in function 74. The presence of cartilage defects could indicate early stages of the arthritic cascade, and the involvement of other tissues such as periarticular tissues, subchondral bone or synovial tissue 71 74 78 79…”

Anti-Arthritic Efficacy And Safety Of Crominex® 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

“…The diagnosis of OA in canine patients is based upon history, physical exam and radiographic evidence. Finally, MRI findings reveal the changes of joint and cartilage degeneration consistent with OA [26][27][28][29][30].…”

“…The diagnosis of OA in canine patients is based upon history, physical exam and radiographic evidence. Finally, MRI findings reveal the changes of joint and cartilage degeneration consistent with OA [26][27][28][29][30].Canines with OA are treated with multipronged approaches, involving invasive as well as non-invasive measures. The objectives in managing OA include minimizing joint pain by reducing the inflammation and slowing the progression of the cartilage damage and thereby increasing the joint flexibility and quality of life.…”

Evaluation of Terminalia chebula Extract for Anti-Arthritic Efficacy and Safety in Osteoarthritic Dogs

“…CT scan and/or MRI findings reveal changes of the joint and cartilage degeneration, which are consistent with OA, but are limited to humans and experimental studies [31][32][33].…”