Association of catalase (rs7943316) and glutathione peroxidase-1 (rs1050450) polymorphisms with the risk of type 2 diabetes (T2DM)

Saravani, Samira; Miri, H R; Saravani, Ramin; Yari, Davood; Nakhaee, Alireza; Mahjoubifard, Maziar

doi:10.3103/s0891416815040096

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…Mutation or polymorphism in promotor genes can enhance or reduce messenger RNA level and consequently protein expression. Polymorphism in CAT gene promotors is predominantly linked with several disorders such as cancers, diabetes, obesity, depression, and other diseases accompanied by oxidative stress (Saravani et al, 2015). Single‐nucleotide polymorphism in the antioxidant enzyme gene is associated with the sperm DNA damage.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant enzymes and association of CAT SNP‐21 A/T (rs7943316) with male infertility

Sadia

Sultan

Khan

et al. 2021

Molecular Reproduction Devel

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Infertility is a multifactorial and polygenic disease. A vast majority of infertility is still unexplained despite modern diagnostic techniques. Oxidative stress is considered a factor for male infertility but etiology in terms of functional gene polymorphism and experimental studies on human subjects is scarcely reported. The aim of the study was to investigate the status of three antioxidant enzymes; catalase, superoxide dismutase (SOD), and glutathione reduced (GSH) in clinically diagnosed infertile males and find the potential association of CAT gene variant in the promoter region −21 A/T (rs7943316). The study consisted of 55 clinically diagnosed infertile males and 50 non‐infertile volunteers. The activity of antioxidant enzymes was measured through a spectrophotometer. Polymerase chain reaction–restriction fragment length polymorphism was performed for genotyping of single‐nucleotide polymorphism. Catalase enzyme activity was significantly decreased while SOD and GSH were substantially increased (p ≤ 0.01) in infertile men in comparison to non‐infertile. CAT gene variant rs7943316 had shown significant association in dominant, recessive model and allelic frequencies. The study concludes that rs7943316 has a substantial role in male infertility. The outcome of the study may help in resolving idiopathic infertility cases and may help in evolving novel diagnostic and therapeutic approaches. Other variants of CAT and antioxidant genes are suggested to ascertain further insight.

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Section: Introductionmentioning

confidence: 99%

Antioxidant enzymes and association of CAT SNP‐21 A/T (rs7943316) with male infertility

Sadia

Sultan

Khan

et al. 2021

Molecular Reproduction Devel

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“…Gene polymorphism plays an important role in several diseases [5], [6]. Previous studies have documented Pro198Leu polymorphisms in Type 2 Diabetes Mellitus (T2DM) [7], [8]. In T2DM Caucasian patients showed that the frequencies of genotypes and alleles of the GPx-1 gene were 51% CC, 37% CT, 12% TT, and 70% C and 30% T [9], but in T2DM Iranian showed only CT genotype (100%) [7].…”

Section: Introductionmentioning

confidence: 99%

Glutathione Peroxidase-1 Pro198Leu Variant in Tuberculosis-infected Type2 Diabetes Mellitus Patients at Pulmonary Polyclinic Medan

Arrasyid

Daulay

Sari

2021

Open Access Maced J Med Sci

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BACKGROUND: Glutathione peroxidase-1 (GPx-1) is an antioxidant that plays an important to the body protection system against oxidative stress. The GPx-1 polymorphism that has been identified in individual with several diseases. AIM: This study aimed to observe the distribution of GPx-1 Pro198Leu variant in tuberculosis (TB)-infected Type 2 diabetes mellitus (T2DM) patients at pulmonary polyclinic Medan. GPx-1 Pro198Leu polymorphism was genotyped in 40 T2DM patients that also infected by TB. MATERIALS AND METHODS: Analysis of GPx-1 Pro198Leu polymorphism was done using polymerase chain reaction (PCR) and restriction fragment length polymorphism. The PCR products were digested 4 h at 37°C with Apa1 restriction enzyme. The result of Apa1 enzyme digestion was visualized with 4% agarose. RESULTS: From 40 TB-infected T2DM patients, the frequency of genotypes CC,CT, and TT were, respectively, 82.5%, 17.5%, and 0%. The frequency of C allele was higher than T allele, i.e. 91.3% and 8.7%. CONCLUSION: It was concluded that in TB-infected T2DM patients at pulmonary polyclinic Medan, the GPx-1 Pro198Leu polymorphism has CC variant higher than CT, whereas the TT genotype was not found. The frequency of the C allele is higher than the T allele.

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“…Type 2 diabetes (T2D) is detected by insulin resistance in tissues dependent to insulin and diminished insulin secretion from pancreatic beta cells (1)(2)(3). Insulin receptor substrate 1 (IRS-1) gene has been suggested significantly by playing a role in susceptibility to T2D (4).…”

Section: Introductionmentioning

confidence: 99%

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

Saravani

Noorzehi

Galavi

et al. 2017

Iran Red Crescent Med J

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Background: Since insulin receptor substrate-1 (IRS-1) is the main substrate of the insulin receptor tyrosine kinase and has been detected to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a possible candidate for development of type2 diabetes, insulin resistance, and obesity. Preilipin (PLIN) coats intracellular lipid droplets and modulates adipocyte lipolysis. Objectives: In this study, we investigated whether insulin receptor substrate-1 (IRS-1) and Perilipin (PLIN) genes polymorphism were associated with Type 2 diabetes (T2D), obesity, and lipid profiles in a sample of the Iranian population (Southeast of Iran). Methods: In this randomized case-control study (Feb, 2016

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Association of catalase (rs7943316) and glutathione peroxidase-1 (rs1050450) polymorphisms with the risk of type 2 diabetes (T2DM)

Cited by 16 publications

References 22 publications

Antioxidant enzymes and association of CAT SNP‐21 A/T (rs7943316) with male infertility

Antioxidant enzymes and association of CAT SNP‐21 A/T (rs7943316) with male infertility

Glutathione Peroxidase-1 Pro198Leu Variant in Tuberculosis-infected Type2 Diabetes Mellitus Patients at Pulmonary Polyclinic Medan

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

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