Association of CD4⁺CD25⁺T Cells with Prevention of Severe Destructive Arthritis inBorrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody

Abstract

CD4؉ CD25 Our investigators showed previously that Borrelia burgdorferi-vaccinated gamma interferon-deficient (IFN-␥°) mice challenged with B. burgdorferi developed a prominent chronic destructive osteoarthropathy (13). The tibiotarsal joint of vaccinated and challenged mice displayed chronic hypertrophy and hyperplasia characterized by erosion of articular cartilage and focal destruction of bone. Treatment of vaccinated IFN-␥°m ice with anti-interleukin-17 (IL-17) antibody followed by challenge with B.

Expanded role for interleukin‐17 in lyme arthritis: Comment on the article by Codolo et al

“…We showed that neutralization of IL-17 in Borrelia-vaccinated and -infected mice leads to the production of an inordinate number of CD4ϩCD25ϩ T cells in the local lymph nodes (7). Administration of anti-CD25 antibody in these anti-IL-17 antibody-treated, Borreliavaccinated and -infected mice reduces the number of CD4ϩ CD25ϩ T cells in the local lymph nodes, and more importantly, results in the development of severe, destructive arthritis (7).…”

“…In summary, the studies by Codolo and colleagues (1) and those using the Borrelia vaccination and challenge model of Lyme arthritis (3)(4)(5)(6)(7)(8) can be used to further explore the complex immunologic pathways responsible for the development and resolution of Lyme arthritis.…”

Do Behçet's syndrome patients with acne and arthritis comprise a true subset? Comment on the article by Hatemi et al

“…We showed that neutralization of IL-17 in Borrelia-vaccinated and -infected mice leads to the production of an inordinate number of CD4ϩCD25ϩ T cells in the local lymph nodes (7). Administration of anti-CD25 antibody in these anti-IL-17 antibody-treated, Borreliavaccinated and -infected mice reduces the number of CD4ϩ CD25ϩ T cells in the local lymph nodes, and more importantly, results in the development of severe, destructive arthritis (7). In addition, the transfer of enriched CD4ϩCD25ϩ T cells obtained from anti-IL-17 antibody-treated, Borrelia-vaccinated and -infected mice into untreated Borrelia-vaccinated and -infected mice prevents the development of pathologic changes (8), suggesting that these cells have immunoregulatory properties.…”

“…We showed that neutralization of IL-17 in Borrelia-vaccinated and -infected mice leads to the production of an inordinate number of CD4ϩCD25ϩ T cells in the local lymph nodes (7). Administration of anti-CD25 antibody in these anti-IL-17 antibody-treated, Borreliavaccinated and -infected mice reduces the number of CD4ϩ CD25ϩ T cells in the local lymph nodes, and more importantly, results in the development of severe, destructive arthritis (7).…”

“…Within the past decade, musculoskeletal US has been recognized as a fundamental imaging technique for the diagnosis and followup of patients with rheumatic diseases (6,7), and it has already been used for the assessment of joint involvement in Behçet's syndrome. In fact, we have recently used US to evaluate knee involvement in a series of 30 consecutive Italian Behçet's syndrome patients, and the results demonstrated a high prevalence of signs of synovitis even among patients without symptoms (8).…”