2013
DOI: 10.4172/2329-6887.1000111
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Association of CD69 and CD 25 Activation Markers on CD4 and CD8 Cells with Skin Tests in Drug Allergy

Abstract: Background: Diagnosis of drug allergy is difficult because few methods have been validated in the literature. In the last few years, identification of T cell activation markers to assess drug allergy has been the focus of several studies.Objective: The aim of the present work was to search for CD25 and CD69 markers on T CD4+ and T CD8+ cells in drug allergy.

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“…Next, a selection of cell activation markers was investigated on the surface of PBMC populations in blood and mucosal tissue in our cohorts. Due to panel and tissue size limitation we focused on investigating expression of CD38 – a receptor and enzyme crucial to immunometabolic pathways and effector functions in most PBMC populations ( 30 ), PD-1 – an immune checkpoint protein ( 31 ), HLA-DR – Human Leukocyte Antigen – DR isotype involved in antigen presentation ( 32 , 33 ), CD69 – general early activation marker ( 34 , 35 ) and CD45RA – a marker of naïve lymphocytes ( 36 ). When we performed multivariate analysis (PCA) of chosen surface activation markers, we observed no clear separation of our groups in blood PBMC populations ( Figure 4A ), in contrast to activation markers on populations in esophageal biopsies that showed good separation and stronger changes between our patient groups ( Figure 4B ).…”
Section: Resultsmentioning
confidence: 99%
“…Next, a selection of cell activation markers was investigated on the surface of PBMC populations in blood and mucosal tissue in our cohorts. Due to panel and tissue size limitation we focused on investigating expression of CD38 – a receptor and enzyme crucial to immunometabolic pathways and effector functions in most PBMC populations ( 30 ), PD-1 – an immune checkpoint protein ( 31 ), HLA-DR – Human Leukocyte Antigen – DR isotype involved in antigen presentation ( 32 , 33 ), CD69 – general early activation marker ( 34 , 35 ) and CD45RA – a marker of naïve lymphocytes ( 36 ). When we performed multivariate analysis (PCA) of chosen surface activation markers, we observed no clear separation of our groups in blood PBMC populations ( Figure 4A ), in contrast to activation markers on populations in esophageal biopsies that showed good separation and stronger changes between our patient groups ( Figure 4B ).…”
Section: Resultsmentioning
confidence: 99%