Association of chemokine CCL5 and systemic malignancies

Kapoor, Shailendra

doi:10.1007/s10038-008-0270-6

J Hum Genet

2008

DOI: 10.1007/s10038-008-0270-6

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Association of chemokine CCL5 and systemic malignancies

Shailendra Kapoor

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2011

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Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

Jenkins¹,

Clarke²,

Canals³

et al. 2011

Journal of Biological Chemistry

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In the present study using a chemokine/cytokine screen, we identified the chemokine CCL5 (formerly known as RANTES) as a candidate-specific downstream target for aSMase. Regulation of CCL5 by aSMase was subsequently validated using both loss-offunction and gain-of-function models indicating that aSMase is both necessary and sufficient for CCL5 production. Interestingly, cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 induction, whereas cells deficient in sphingosine kinase-1 and -2 exhibited higher levels of CCL5, suggesting that sphingosine and not sphingosine 1-phosphate (S1P) is responsible for the positive signal to CCL5. Consistent with this, co-expression of aSMase and aCDase was sufficient to strongly induce CCL5. Taken together, these data identify a novel role for aSMase (particularly S-SMase) in chemokine elaboration by pro-inflammatory cytokines and highlight a novel and shared function for aSMase and aCDase.

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Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

Jenkins¹,

Clarke²,

Canals³

et al. 2011

Journal of Biological Chemistry

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show abstract

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Association of chemokine CCL5 and systemic malignancies

Cited by 1 publication

References 9 publications

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

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