Association of chemokine ligand 5/chemokine receptor 5 gene promoter polymorphisms with diabetic microvascular complications: A meta‐analysis

Abstract

Aims/IntroductionChemokine ligand 5 (CCL5) is a member of the CC‐chemokine family expressed in various organs. It contributes to the migration of monocytes/macrophages into injured vascular walls by binding with its receptor chemokine receptor 5 (CCR5). Many studies have accessed the association between CCL5/CCR5 gene promoter polymorphisms and diabetic microvascular complications (DMI). However, the results are conflicting and inconclusive. The aim of the present study was to evaluate the association more precisely.Materials and MethodsTrials were retrieved through PubMed, Embase, Medline, China National Knowledge Infrastructure, Web of Science and Cochrane database without restrictions on language. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the strength of association with DMI.ResultsData were obtained from 11 case–control studies that included 2,737 DMI patients and 2,435 diabetic control subjects. In the overall analysis, the CCL5‐403 G/A and CCL5‐28 C/G gene polymorphisms were not significantly associated with the risk of DMI. However, CCR5‐59029 G/A was an independent risk factor of DMI in a dominant model (OR 1.77, 95% CI 1.06–2.97). Subgroup analysis showed that the risk of the CCR5 59029A‐positive genotype was significant in Asians (OR 2.08, 95% CI 1.68–2.57). In addition, the CCR5 59029A‐positive genotype was associated with increased risk of albuminuria.ConclusionsThere were no associations of CCL5 gene promoter polymorphism with the risk of DMI. However, the 59029A polymorphism in CCR5 might affect individual susceptibility for DMI.

Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients

“…Its gene is located on the short arm of chromosome 3 (3p21.31) [11] at the promoter region. Though there are conflicting and inconclusive reports on the association of CCR5 gene promoter polymorphism with the risk of DN, the polymorphism in CCR5 might affect individual susceptibility to DN [12]. The gene, however, has been reported to have an association to nephropathy in T2DM among the Japanese and Asian Indian population [13–16].…”

Chemokine Receptor 5, a Double-Edged Sword in Metabolic Syndrome and Cardiovascular Disease

“…Previous studies have found that CCR5-59029 G/A was an independent risk factor for DKD (Yahya et al, 2019). The CCR5 59029A-positive genotype was correlated with an increased risk for albuminuria (Zhang et al, 2016). Mlynarski et al (2005) showed that the CCR5-D32 mutation increased the risk of kidney disease in men with type 1 diabetes; however, this outcome is contrary to that of Prasad et al (2007) who found that CCR5-D32 was not related to nephropathic type 2 diabetes patients.…”

Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan

“…All of the genetic markers were selected based on previous reports. The inclusion criteria of candidate SNPs were set as a combined P < 10 −4 for GWAS 18 , 19 , 23 , 29 and a P < 0.05 for meta-analysis 20 , 21 , 30 – 50 . A total of 58 SNPs in 44 susceptibility loci were evaluated in our study (details are summarized in Table S1 ).…”