Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Xie, Zhiqin; Li, Hongxia; Tan, Wenliang; Yang, Lei; Ma, Xiao-Wu; Li, Wenxin; Wang, Qingbin; Shang, Chao; Chen, Yajin

doi:10.3389/fmed.2021.787777

Cited by 10 publications

(13 citation statements)

References 43 publications

(53 reference statements)

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“…We previously studied the relationship of NAFLD with gallstone disease using NHANES 1988-1994 and found that in the US population, NAFLD was associated with cholecystectomy, but not gallstones 40. An association of cholecystectomy with liver fibrosis and cirrhosis defined by liver stiffness was reported using NHANES 2017-2018 41. However, the direction of relationships cannot be determined with certainty using cross-sectional survey data.…”

Section: Discussionmentioning

confidence: 99%

“…[40] An association of cholecystectomy with liver fibrosis and cirrhosis defined by liver stiffness was reported using NHANES 2017-2018. [41] However, the direction of relationships cannot be determined with certainty using cross-sectional survey data. Current alcohol use was associated with lower odds of gallstone disease after accounting for other factors.…”

Section: Discussionmentioning

confidence: 99%

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Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US

Ruhl

2023

Hepatology

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Background and Aims: We examined gallbladder and biliary tract mortality predictors in the US National Health and Nutrition Examination Survey (NHANES), 1988-1994, with 31 years of linked mortality data, and gallstone disease prevalence trends and associations in NHANES 2017-March 2020 prepandemic data. Approach and Results: In NHANES 1988-1994, 18,794 participants were passively followed for mortality, identified by death certificate underlying or contributing causes, by linkage to the National Death Index through 2019. In NHANES 2017-March 2020, gallstone disease history was ascertained from 9232 adults. During NHANES 1988-2019 follow-up (median, 23.3 y), 8580 deaths occurred from all causes and 72 deaths with gallbladder or biliary tract disease. In multivariable-adjusted analysis, older age, male sex, prediabetes or diabetes, and physical inactivity were associated with gallbladder and biliary tract mortality, and non-Hispanic Black and Mexican American race-ethnicity were inversely associated. Between 1988-1994 and 2017-March 2020, gallstone disease prevalence increased from 7.4% to 13.9% and gallbladder surgery from 6.0% to 11.6%. In 2017-March 2020 in multivariable-adjusted analysis, female sex, diabetes, liver disease, proton pump inhibitors, abdominal pain, increased age, BMI, and liver stiffness were associated with gallstone disease, and non-Hispanic Black and non-Hispanic Asian race and alcohol were inversely associated. Conclusions: In the US population, gallstone disease prevalence doubled over 3 decades, possibly because of the worsening of metabolic risk factors and growth of laparoscopic cholecystectomy. Gallbladder and biliary tract mortality and gallstone disease associations included factors such as prediabetes or diabetes, liver stiffness and proton pump inhibitors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US

Ruhl

2023

Hepatology

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“…Cholecystectomy and MASLD are two of the most common medical conditions when we refer to the gastrointestinal tract. Although the studies published on both topics are not usually linked to each other, there is evidence that cholecystectomy may worsen the course of MASLD [ 50 , 51 , 52 ]. Cholecystectomy has also been considered an independent risk factor for MASLD [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

“…When the search was extended to NAFLD definition, some contradictory studies were observed, but most of them considered cholecystectomy to be a risk factor for liver fibrosis. Xie et al [ 52 ] performed a study including almost 5000 patients, in which a positive correlation was concluded between cholecystectomy and liver fibrosis. Kichloo et al [ 74 ] conducted a study in hospitalized patients in which it was obtained as a result that cholecystectomy and gallstone disease may be risk factors for NAFLD.…”

Section: Discussionmentioning

confidence: 99%

A Machine Learning-Based Method for Detecting Liver Fibrosis

Suárez,

Martínez,

Torres

et al. 2023

Diagnostics

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Cholecystectomy and Metabolic-associated steatotic liver disease (MASLD) are prevalent conditions in gastroenterology, frequently co-occurring in clinical practice. Cholecystectomy has been shown to have metabolic consequences, sharing similar pathological mechanisms with MASLD. A database of MASLD patients who underwent cholecystectomy was analysed. This study aimed to develop a tool to identify the risk of liver fibrosis after cholecystectomy. For this purpose, the extreme gradient boosting (XGB) algorithm was used to construct an effective predictive model. The factors associated with a better predictive method were platelet level, followed by dyslipidaemia and type-2 diabetes (T2DM). Compared to other ML methods, our proposed method, XGB, achieved higher accuracy values. The XGB method had the highest balanced accuracy (93.16%). XGB outperformed KNN in accuracy (93.16% vs. 84.45%) and AUC (0.92 vs. 0.84). These results demonstrate that the proposed XGB method can be used as an automatic diagnostic aid for MASLD patients based on machine-learning techniques.

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“…Logistic regression models have also been used to create predictive algorithms that describe the probability of an event using nomograms or online calculators, such as assessment of fibrosis and prediction of survival of patients with HCC [139][140][141]. Alternatively, logistic regression models have been applied to calculate propensity scores, which can be used to adjust the imbalance of baseline confounders between two cohorts when the goal is to compare their identical outcomes [142,143]. Furthermore, because the outcome variables are binary, logistic regression can be used for binary classification tasks.…”

Section: Logistic Regressionmentioning

confidence: 99%

Radiobioinformatics: A novel bridge between basic research and clinical practice for clinical decision support in diffuse liver diseases

Lei

et al. 2023

iRADIOLOGY

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The liver is a multifaceted organ that is responsible for many critical functions encompassing amino acid, carbohydrate, and lipid metabolism, all of which make a healthy liver essential for the human body. Contemporary imaging methodologies have remarkable diagnostic accuracy in discerning focal liver lesions; however, a comprehensive understanding of diffuse liver diseases is a requisite for radiologists to accurately diagnose or predict the progression of such lesions within clinical contexts. Nonetheless, the conventional attributes of radiological features, including morphology, size, margin, density, signal intensity, and echoes, limit their clinical utility. Radiomics is a widely used approach that is characterized by the extraction of copious image features from radiographic depictions, which gives it considerable potential in addressing this limitation. It is worth noting that functional or molecular alterations occur significantly prior to the morphological shifts discernible by imaging modalities. Consequently, the explication of potential mechanisms by multiomics analyses (encompassing genomics, epigenomics, transcriptomics, proteomics, and metabolomics) is essential for investigating putative signal pathway regulations from a radiological viewpoint. In this review, we elaborate on the principal pathological categorizations of diffuse liver diseases, the evaluation of multiomics approaches pertaining to diffuse liver diseases, and the prospective value of predictive models. Accordingly, the overarching objective of this review is to scrutinize the interrelations between radiological features and bioinformatics as well as to consider the development of prediction models predicated on radiobioinformatics as integral components of clinical decision support systems for diffuse liver diseases.

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Association of Cholecystectomy With Liver Fibrosis and Cirrhosis Among Adults in the USA: A Population-Based Propensity Score-Matched Study

Cited by 10 publications

References 43 publications

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US

Increasing gallstone disease prevalence and associations with gallbladder and biliary tract mortality in the US

A Machine Learning-Based Method for Detecting Liver Fibrosis

Radiobioinformatics: A novel bridge between basic research and clinical practice for clinical decision support in diffuse liver diseases

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