Association of chromosomal region 9p21.3 with Coronary Artery Disease – A local perspective

Bellary, Kalpana; Murthy, Dwarkanath K.; Vala, Dayasagar Rao; Hanumanth, Surekha Rani; Quraishi, Mohammad Kaleemullah

doi:10.1016/j.jicc.2016.12.002

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…p16INK4a and p15INK4b specifically bind to CDK inhibitors 6 and 4, causes cell-cycle arrest in G1 phase. The knock-out of CDKN2A or CDKN2B in mice is kenned to cause tumors within months (Bellary, Murthy, Vala, Hanumanth, & Quraishi, 2016;Krimpenfort et al, 2007). Another gene named methylthioadenosine phosphorylase (MTAP) is also found in 9p21.3 locus, which is observed in many different human tumors (Kadariya et al, 2009;Kim et al, 2012).…”

Section: Genetic Basis Of Cadmentioning

confidence: 99%

A review on coronary artery disease, its risk factors, and therapeutics

Malakar

Choudhury

Halder

et al. 2019

Journal Cellular Physiology

766

428

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Coronary artery disease (CAD) is one of the major cardiovascular diseases affecting the global human population. This disease has been proved to be the major cause of death in both the developed and developing countries. Lifestyle, environmental factors, and genetic factors pose as risk factors for the development of cardiovascular disease. The prevalence of risk factors among healthy individuals elucidates the probable occurrence of CAD in near future. Genome‐wide association studies have suggested the association of chromosome 9p21.3 in the premature onset of CAD. The risk factors of CAD include diabetes mellitus, hypertension, smoking, hyperlipidemia, obesity, homocystinuria, and psychosocial stress. The eradication and management of CAD has been established through extensive studies and trials. Antiplatelet agents, nitrates, β‐blockers, calcium antagonists, and ranolazine are some of the few therapeutic agents used for the relief of symptomatic angina associated with CAD.

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Section: Genetic Basis Of Cadmentioning

confidence: 99%

A review on coronary artery disease, its risk factors, and therapeutics

Malakar

Choudhury

Halder

et al. 2019

Journal Cellular Physiology

766

428

View full text Add to dashboard Cite

show abstract

“…P16INK4a e p15INK4b se ligam especificamente aos inibidores de CDK 6 e 4, causando parada do ciclo celular na fase G1. Sabese que a eliminação de CDKN2A ou CDKN2B em camundongos causa tumores em alguns meses 18 .…”

Section: Base Genéticaunclassified

Uma Revisão Dos Aspectos Mais Característicos Da Doença Arterial Coronariana E Seus Principais Fatores De Risco

Oliveira,

Silva,

Fonseca

et al. 2024

Coração Em Foco: Explorando Os Aspectos Fundamentais Da Saúde Cardíaca

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“…Existence of polymorphism (rs1537370) causes increased ANRIL expression level and so a reduction in CDKN2A and CDKN2B levels and increased VSMC proliferation that may result in atherosclerosis and predisposition to coronary artery calcification. 5 , 51 , 52 …”

Section: Introductionmentioning

confidence: 99%

Vascular calcification; Stony bridge between kidney and heart

Zaker

Ardalan

2020

J Cardiovasc Thorac Res

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Vascular calcification is a high prevalent complication that arises as a consequence of impaired calcium and phosphate balance amongst cardiovascular patients. Multiple inducer/ inhibitory molecules and pathways as well as genetic background and lifestyle play role in this phenomenon. According to which vessel layer (intima, media or both) is involved different types of vascular calcification take place. Actual mechanism and consensus pathways have not been elucidated yet and needs further investigations.

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Association of chromosomal region 9p21.3 with Coronary Artery Disease – A local perspective

Cited by 5 publications

References 30 publications

A review on coronary artery disease, its risk factors, and therapeutics

A review on coronary artery disease, its risk factors, and therapeutics

Uma Revisão Dos Aspectos Mais Característicos Da Doença Arterial Coronariana E Seus Principais Fatores De Risco

Vascular calcification; Stony bridge between kidney and heart

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