Association of chronic periodontitis with white blood cell and platelet count - A Case Control Study

Kumar, Balmuri Praveen; Khaitan, Tanya; Ramaswamy, P; Pattipati, Sreenivasulu; Uday, G; Velugubantla, Ragha Geethika

doi:10.4317/jced.51292

Cited by 26 publications

(25 citation statements)

References 9 publications

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“…In a study with fifty chronic periodontitis patients and fifty control individuals with normal periodontal tissue, Al‐Rasheed () showed that the leukocyte count was higher in the chronic periodontitis patients than in their counterparts (7.22 ± 1.42 × 10 9 cells/L vs 5.64 ± 1.56 × 10 9 cells/L, respectively; P < 0.001). Another case‐controlled study reported that the leukocyte count was higher in patients between 30 and 50 years of age with chronic periodontitis (Kumar et al , ). Furthermore, Pink et al () observed that the leukocyte count was directly correlated with a risk of periodontitis in the German population.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, early detection of periodontitis is important from a public health perspective and the leukocyte count could be a useful predictor of this disease. Although previous research has consistently shown a positive association between elevated leukocytes and periodontitis, these were few in number and were small‐sized, randomly sampled population‐based studies (Christan et al , ; Al‐Rasheed, ; Kumar et al , ). And there are few studies to examine the relationship between leukocyte count and periodontitis based on nationwide survey in Asian populations.…”

Section: Introductionmentioning

confidence: 98%

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Elevated leukocyte count is associated with periodontitis in Korean adults: the 2012–2014 KNHANES

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Elevated leukocyte count is associated with periodontitis in Korean adults: the 2012–2014 KNHANES

et al. 2016

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“…Kumar et al [29] found that WBC levels are increased in the case of periodontitis in humans. Rawlinson et al [30] stated that the chronic infl ammatory process may or may not be associated with an increase in the number of WBCs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Systemic Inflammation Parameters in Dogs with Periodontitis

et al. 2019

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Periodontal diseases are the most common diseases in veterinary medicine. The first clinical finding is chewing difficulty, saliva flow and bad oral odor. It further develops into plaque and tartar formation, gingival inflammation and hemorrhagic appearance of the gingiva, periodontal pockets formation, alveolar bone resorption and tooth loss. In this study an evaluation has been made to determine which degree reflects on the parameters of systemic inflammatory reaction with special attention to IL-6 (Interleukine-6), CRP (C-reactive protein), osteopontin, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx) and Ig (Immunglobulins = Total protein – Albumin) and hematological parameters in dogs with periodontitis. Two groups have been defined in this study. The first group included 10 healthy and owned dogs as a control group. The second group consisted of 10 owned dogs with moderate-severe periodontitis. The difference between monocyte (p <0.001) and neutrophil (p <0.05) counts was found to be significant. In addition, the difference between SOD, MDA, glutathione peroxidase, CRP, IL-6 measurements in group 1 and group 2 was significant. (p <0.001). The level of osteopontin in moderate-severe periodontitis cases was found significantly higher than the level measured in the healthy group. Measured values in the moderate-severe periodontitis cases are higher than the healthy group in terms of CRP, IL-6, and osteopontin levels. Increasing severity of periodontitis was associated with changes in oxidative stress parameters: increased MDA, decreased SOD and glutathione peroxidase levels. These differences provide important information about the evaluation of the cellular responses. There is a need for continued research into the systemic impact of periodontal disease.

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“…Reduction in blood flow especially in narrow or blocked arteries due to atherosclerotic plaque formation can be an important etiologic factor for various cardiovascular diseases. 6,7 An increase in number of active thrombocytes can occur in inflammatory and infectious process and this is known as "Reactive Thrombocytosis". 8 Periodontal pathogens such as P. gingivalis and A. actinomycetemcomitans can activate thrombocytes which occurs mainly in the granulation tissue where thrombocytes internalize bacteria or bacterial antigens and as a result produce antimicrobial peptides and cytokines.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of peripheral blood levels in patients with chronic and aggressive periodontitis: A clinico- biochemical study

2020

IJPI

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Introduction: Periodontitis is an inflammatory disease often chronic in nature characterized by destruction of both hard and soft tissues surrounding the teeth which may eventually lead to loss of teeth. Periodontitis results from immune inflammatory response to certain gram negative anaerobes in a susceptible host. Aim: The aim of the present study was to evaluate peripheral blood levels in healthy subjects, chronic and aggressive periodontitis patients and to assess whether increased levels of periodontal parameters in these subjects with chronic and aggressive periodontitis can influence the peripheral blood levels in the three study groups. Materials and Methods: The study was carried out on 55 subjects with male and female ratios of 27: 28 and included 20 controls, 20 patients with chronic periodontitis (Both localized and generalized cases) and 5 localized and 10 generalized aggressive periodontitis patients. Blood samples were collected from healthy controls (n=20) and patients with chronic periodontitis (n=20) and aggressive periodontitis (n=15). Recording of Oral Hygiene Index-Simplified (OHI-S), Bleeding Index (BI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL) was done to evaluate the periodontal status of each patient. Blood was collected and transported to a lab within four hours after venepuncture for processing and peripheral blood parameters were evaluated. Data presentation was done in the form of mean and standard deviation and analysis of data was done using one way ANOVA and Students t-test to test the statistical significance between study groups. Results: An increase in peripheral blood levels of WBC and platelets were observed in both study groups whereas RBC and hemoglobin level were found to decrease in both the study groups when compared to healthy controls and this was found to be statistically significant (P<0.001). Conclusion: The findings of the present study indicates that there is a statistically significant correlation between presence and intensity of periodontitis and peripheral blood levels.

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Association of chronic periodontitis with white blood cell and platelet count - A Case Control Study

Cited by 26 publications

References 9 publications

Elevated leukocyte count is associated with periodontitis in Korean adults: the 2012–2014 KNHANES

Elevated leukocyte count is associated with periodontitis in Korean adults: the 2012–2014 KNHANES

Evaluation of Systemic Inflammation Parameters in Dogs with Periodontitis

Evaluation of peripheral blood levels in patients with chronic and aggressive periodontitis: A clinico- biochemical study

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