Association of Circulating Biomarkers (Adrenomedullin, TNFR1, and NT-proBNP) With Renal Function Decline in Patients With Type 2 Diabetes: A French Prospective Cohort

Saulnier, Pierre‐Jean; Gand, Elise; Velho, Gilberto; Mohammedi, Kamel; Zaoui, Philippe; Fraty, M.; Halimi, Jean Michel; Roussel, Ronan; Ragot, Stéphanie; Hadjadj, Samy

doi:10.2337/dc16-1571

Cited by 47 publications

(42 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A range of other potential biomarkers have been studied in the context of DKD (6). The current study aligns with recent studies describing the prognostic utility of tumor necrosis factor receptor (TNFR) 1 and TNFR2 (9,12,34,35). Our biomarker panel provided a similar discriminative ability (sensitivities of 83-94% and specificities of 72-80% for clinical plus biomarker model 2) to published data on TNFR1/TNFR2 for predicting renal decline (sensitivities of 68-72% and specificities of 81-86%) (36).…”

Section: Discussionsupporting

confidence: 76%

“…Adopting this approach showed that most rapid decliners in the current study were in the highest apoA4/C1QB quartile or the lowest CD5L/IBP3 quartile (data not shown), but these results should be interpreted with caution because of small cell numbers. A recent study of 1,135 participants with type 2 diabetes with baseline renal function similar to those in the current study (12) showed that plasma adrenomedullin, TNFR1, and N-terminal pro B-type natriuretic peptide were associated with rapid eGFR decline, independent of established risk factors, and that they significantly increased the receiver operating characteristic AUC (ΔAUC = 0.027-0.054, P , 0.0001). We found a similar significant increase in AUC after the addition of the biomarkers to the clinical prediction model for eGFR trajectory ( Table 2) (ΔAUC = 0.07, P = 0.039).…”

Section: Discussionsupporting

confidence: 69%

“…Given the prognostic limitations of ACR and eGFR, there has been a focus on alternative biomarkers that could identify patients who are at increased risk of DKD. This includes studies of a range of plasma proteins (6)(7)(8)(9)(10)(11)(12), but most of these have been limited by small sample sizes; the exclusion of patients without albuminuria and/or CKD; and/or the inclusion of patients who are not representative of type 2 diabetes in the community, such as those participating in clinical trials or those who have been selected from hospital outpatient clinics.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Peters

Davis

Ito³

et al. 2017

Diabetes Care

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 69%

mentioning

confidence: 99%

See 1 more Smart Citation

Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Peters

Davis

Ito³

et al. 2017

Diabetes Care

View full text Add to dashboard Cite

show abstract

“…27 In patients with diabetes, elevated sTNFR-1 concentrations have been associated with CKD progression and development of ESRD. 6,28 However, it is unknown whether sTNFR-1 concentrations are associated with kidney function decline in a population without cardiovascular disease and low prevalence of diabetes. In this context, this study leverages the MESA's longitudinal follow-up to suggest that serum sTNFR-1 concentrations may be important before the development of kidney decline, regardless of baseline kidney function.…”

Section: Discussionmentioning

confidence: 99%

Association of Soluble TNFR-1 Concentrations with Long-Term Decline in Kidney Function: The Multi-Ethnic Study of Atherosclerosis

Bhatraju

Zelnick

Shlipak

et al. 2018

JASN

View full text Add to dashboard Cite

Background TNF receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. Higher soluble TNF receptor-1 (sTNFR-1) concentrations are associated with kidney disease progression among persons with established diabetic kidney disease. However, no studies have assessed sTNFR-1's role in longterm kidney function changes in a multiethnic population without cardiovascular disease at baseline. MethodsWe tested associations between baseline sTNFR-1 concentrations and 10-year decline in eGFR (incident $40% decline and annual proportional decline) among 2548 participants in the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective cohort study. Serum creatinine concentrations were determined at enrollment and study years 3, 5, and 10.Results Mean age of participants was 61 years old, 53% were women, and mean baseline eGFR was 79 ml/min per 1.73 m 2 . Serum sTNFR-1 was inversely associated with baseline eGFR. Over median follow-up of 9.3 years, 110 participants developed $40% decline in eGFR; each SD higher concentration of sTNFR1 was associated with higher risk of 40% eGFR decline (adjusted hazard ratio, 1.43; 95% confidence interval [95% CI], 1.16 to 1.77; P,0.001). The highest sTNFR-1 tertile was associated with adjusted annualized decline in eGFR of 1.94% (95% CI, 1.79 to 2.09). Associations persisted across subgroups defined by demographics, hypertension, diabetes, and baseline CKD status.Conclusions Elevated serum sTNFR-1 concentrations are associated with faster declines in eGFR over the course of a decade in a multiethnic population, independent of previously known risk factors for kidney disease progression.

show abstract

“…The specific characteristics of the 11 studies are shown in Table . . Overall, the analysis included 6526 participants from 11 cohorts with TNFR‐1 measurements and 5385 participants from 10 prospective studies with TNFR‐2 measurements.…”

Section: Resultsmentioning

confidence: 99%

Circulating TNF receptors 1 and 2 predict progression of diabetic kidney disease: A meta‐analysis

Luo

Wang

et al. 2019

Diabetes Metabolism Res

View full text Add to dashboard Cite

Background:We conducted a meta-analysis to investigate the association of circulating tumor necrosis factor-1 (TNFR-1) and TNFR-2 with diabetic kidney disease (DKD) progression, which is the first-ever quantitative analysis of these associations thus far. Whether TNFRs were better than albumin-creatinine ratio (ACR) in predicting DKD progression was also explored. Methods:A systematic search of the PubMed, EMBASE, and Cochrane Library databases up to 1 February 2018, was conducted. The main outcome was DKD progression, which was defined as eGFR decline, macroalbuminuria, or incidence of DKD-related events. Eligible studies were included for pooled analysis using either fixed-effects or random-effects models to incorporate between-study variation by different measurement standards. Publication bias was evaluated using Egger's test. Results:The meta-analysis included 6526 participants from 11 cohorts with circulating TNFR-1 measurements and 5385 participants from 10 prospective studies with circulating TNFR-2 measurements. Compared with the lowest level category, diabetic patients with the highest TNFR-1 or TNFR-2 level category exhibited a higher risk of DKD progression (RR 2.51, 95% CI [1.92-3.27] for TNFR-1; 3.23 [1.99-5.26] for TNFR-2). The risk of DKD progression was also increased with the per unit increment of TNFR-1 or ] for TNFR-1; 1.69 [1.31-2.17] for TNFR-2).Although existing studies did not support a direct comparison between ACR and TNFRs, it was undeniable that TNFRs could improve the predictive value in DKD progression. Conclusions:Circulating TNFR-1 and TNFR-2 are reliable predictors of DKD progression. Whether TNFRs are better than ACR at predicting DKD progression needs to be further investigated.

show abstract

Association of Circulating Biomarkers (Adrenomedullin, TNFR1, and NT-proBNP) With Renal Function Decline in Patients With Type 2 Diabetes: A French Prospective Cohort

Abstract: In addition to established risk factors, MR-proADM, sTNFR1, and NT-proBNP improve risk prediction of loss of renal function in patients with type 2 diabetes.

Cited by 47 publications

References 49 publications

Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II

Association of Soluble TNFR-1 Concentrations with Long-Term Decline in Kidney Function: The Multi-Ethnic Study of Atherosclerosis

Circulating TNF receptors 1 and 2 predict progression of diabetic kidney disease: A meta‐analysis

Contact Info

Product

Resources

About