Association of circulating C-reactive protein and high-sensitivity C-reactive protein with components of sarcopenia: A systematic review and meta-analysis of observational studies

Mashhadi, Nafiseh Shokri; Moradi, Sajjad; Heidari, Zahra; Saadat, Saeed

doi:10.1016/j.exger.2021.111330

Cited by 48 publications

(34 citation statements)

References 69 publications

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“…Effective circulating biomarkers are needed to accurately assess MM and diagnose sarcopenia, including C-reactive protein (CRP), high-sensitivity CRP [15], serum creatinine [16], procollagen type III N-terminal peptide (P3NP) [17,18], serine protease high temperature requirement A1 (HtrA1) [17], c-terminal agrin fragment-22 (CAF22), osteonectin, irisin [18], and brain-derived neurotrophic factor (BDNF) [19]. However, their accuracy and usefulness remain under investigation.…”

Section: Introductionmentioning

confidence: 99%

Assessment of sarcopenia and malnutrition using estimated GFR ratio (eGFRcys/eGFR) in hospitalised adult patients

Yoshida

Nakayama

et al. 2022

Clinical Nutrition ESPEN

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Section: Introductionmentioning

confidence: 99%

Assessment of sarcopenia and malnutrition using estimated GFR ratio (eGFRcys/eGFR) in hospitalised adult patients

Yoshida

Nakayama

et al. 2022

Clinical Nutrition ESPEN

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Section: Biomarkers With Increased Concentration In Sarcopeniamentioning

confidence: 99%

“…C-reactive protein (CRP) is an acute-phase protein and a marker of systemic inflammation [ 36 , 62 ]. Ιt has been reported that high levels of CRP can lead to a decrease in the size of muscle cells and downregulate protein kinase B (Akt), which is theoretically related to dysregulation of muscle cells [ 36 , 63 ]. Several studies have shown that increasing levels of inflammatory markers, including CRP, in older adults are associated with increased muscle loss and sarcopenia [ 37 ].…”

Section: Biomarkers With Increased Concentration In Sarcopeniamentioning

confidence: 99%

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Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

et al. 2022

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Due to the multifactorial pathogenesis of sarcopenia, it is crucial to identify biomarkers that are risk factors for sarcopenia, and which therefore have a prognostic function. Aim: This narrative review aims to define a set of biomarkers associated with nutrition and sarcopenia. These biomarkers could contribute to individualized monitoring and enable preventive and therapeutic methods. Methods: Two electronic databases, PubMed and Google Scholar, were used. The search strategy was based on a controlled vocabulary (MeSH) and includes studies published up to February 2022. Discussion: Higher levels of serum uric acid are associated with higher handgrip strength and better muscle function in elderly people and, thus, may slow the progression of sarcopenia. Leptin, an adipokine secreted by adipose tissue, promotes the production of pro-inflammatory cytokines, which in turn lead to sarcopenia. This makes leptin a significant indirect biomarker for physical disability and sarcopenic obesity. Additionally, creatinine is a reliable biomarker for muscle mass status because of its easy accessibility and cost-effectiveness. Vitamin D status acts as a useful biomarker for predicting total mortality, hip fractures, early death, and the development of sarcopenia. Therefore, there is an increasing interest in dietary antioxidants and their effects on age-related losses of muscle mass and function. On the other hand, 3-Methylhistidine is a valuable biomarker for detecting increased muscle catabolism, as it is excreted through urine during muscle degradation. In addition, IGF-1, whose concentration in plasma is stimulated by food intake, is associated with the loss of skeletal muscle mass, which probably plays a crucial role in the progression of sarcopenia. Conclusions: Many nutritional biomarkers were found to be associated with sarcopenia, and can therefore be used as prognostic indexes and risk factors. Nutrition plays an important role in the prevention and management of sarcopenia, affecting muscle mass, strength, and function in elderly people.

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“…FSH has the potential to induce lipid storage, redistribution, and ectopic deposition (7)(8)(9), all factors that have been linked to chronic low-grade inflammatory state which has been recognized as a cause of age-related sarcopenia (10). For example, high-sensitivity C-reactive protein (hs-CRP), a biomarker of systemic inflammation, was found to be independently associated with sarcopenia component in a recent meta-analysis (11). Accordingly, the potential regulation of FSH on skeletal muscle mass has been proposed in the past decade, in which lean mass (mainly muscle) is negatively correlated with FSH levels in both young and old postmenopausal women (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Association Between Serum Follicle-Stimulating Hormone and Sarcopenia and Physical Disability Among Older Chinese Men: Evidence From a Cross-Sectional Study

Xu²,

Zhang³

et al. 2022

Front. Med.

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Background: Sarcopenia is a geriatric syndrome characterized by progressive loss of muscle mass, function and quality and associated with a range of adverse health outcomes including disability. Despite a negative correlation between muscle mass and follicle-stimulating hormone (FSH) levels in postmenopausal women, it is unclear if FSH is associated with sarcopenia and its poor outcomes, especially in older men.Methods: We used cross-sectional data from 360 men aged over 80 who participated in health check-ups to investigate correlations between serum FSH and sarcopenia, individual sarcopenia components, low physical performance (gait speed ≤ 0.8 m/s) and instrumental activities of daily living (IADL) disability. Sarcopenia and severe sarcopenia were diagnosed according to the revised definition of the European Working Group on Sarcopenia in Old People (EWGSOP2).Results: The prevalence of sarcopenia was 17.8% in this population. In binary logistic regression analysis, compared with higher FSH group, lower FSH group showed a significant reduction in the risk of low calf circumference (a surrogate for muscle mass; OR 0.308, 95% CI 0.109–0.868, P = 0.026) after adjusting potential confounders including age, waist circumference, education, exercise, associated biochemical parameters, other sex hormones and high-sensitivity C-reactive protein. The correlation between FSH and low handgrip strength was marginally significant (OR 0.390, 95% CI 0.151–1.005, P = 0.051). No associations were observed between FSH and sarcopenia, severe sarcopenia, and disability in adjusted models.Conclusion: In older men, circulating FSH was not associated with sarcopenia, sarcopenia severity, the majority of its components and adverse health outcome (IADL disability), with the exception of low calf circumference. Further work is needed to better elucidate the association of FSH and low muscle quantity by adopting more accurate measurement method of appendicular skeletal muscle mass such as DXA, CT or MRI.

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Association of circulating C-reactive protein and high-sensitivity C-reactive protein with components of sarcopenia: A systematic review and meta-analysis of observational studies

Cited by 48 publications

References 69 publications

Assessment of sarcopenia and malnutrition using estimated GFR ratio (eGFRcys/eGFR) in hospitalised adult patients

Assessment of sarcopenia and malnutrition using estimated GFR ratio (eGFRcys/eGFR) in hospitalised adult patients

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

Association Between Serum Follicle-Stimulating Hormone and Sarcopenia and Physical Disability Among Older Chinese Men: Evidence From a Cross-Sectional Study

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