Association of circulation very long chain saturated fatty acids with periodontitis in NHANES 2011–2014

Abstract

Background Increased levels of polyunsaturated fatty acids have been shown in several recent studies to lower the incidence of periodontitis. The impact of very long chain saturated fatty acids (VLSFAs) on periodontitis, however, has not received much attention. Therefore, our study’s goal was to ascertain how VLSFAs and periodontitis related to one another in adult Americans. Methods Our analysis comprised 1861 participants from NHANES 2011-2014 who had their serum VLSFA levels measured. Four equal parts of the serum VLSFAs (20:0,22:0,23:0,24:0, and total VLSFA) were used as independent variables. Periodontitis was the dependent variable, and it was categorized using the Eke 2012 criteria. The connection between VLSFAs and periodontitis was examined using a multivariate logistic regression analysis. Results While multiple variables were adjusted, we found a negative correlation between increased 20:0, 23:0, and total VLSFA circulating levels and periodontitis. (model 3, Q4 OR20:0: 0.00053, 95 % CI: 0.420-0.786, P-trend =0.004; OR23:0: 0.624, 95 % CI: 0.454-0.855, P-trend =0.007; OR total VLSFA:0.710, 95 % CI: 0.518-0.972, P-trend=0.049, respectively). Conclusions We conclude that rising levels of 20:0, 23:0, and total VLSFA in the blood could help lower the incidence of periodontitis. Clinical relevance High levels of serum VLSFAs may reduce the risk of periodontitis.