2022
DOI: 10.3389/fped.2022.979777
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Association of citrulline concentration at birth with lower respiratory tract infection in infancy: Findings from a multi-site birth cohort study

Abstract: Assessing the association of the newborn metabolic state with severity of subsequent respiratory tract infection may provide important insights on infection pathogenesis. In this multi-site birth cohort study, we identified newborn metabolites associated with lower respiratory tract infection (LRTI) in the first year of life in a discovery cohort and assessed for replication in two independent cohorts. Increased citrulline concentration was associated with decreased odds of LRTI (discovery cohort: aOR 0.83 [95… Show more

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“…The Tennessee NBS program only provided data for infants whose metabolite concentrations were within the normal range (i.e., screened negative for an inherited disorder) (Figure 1). This reduced the risk of potential participant identification and removed skewed metabolite concentrations due to inborn errors of metabolism [9,17].…”
Section: Newborn Screening Metabolic Data Collectionmentioning
confidence: 99%
“…The Tennessee NBS program only provided data for infants whose metabolite concentrations were within the normal range (i.e., screened negative for an inherited disorder) (Figure 1). This reduced the risk of potential participant identification and removed skewed metabolite concentrations due to inborn errors of metabolism [9,17].…”
Section: Newborn Screening Metabolic Data Collectionmentioning
confidence: 99%