Association of clinic and ambulatory blood pressure with vascular damage in the elderly: the EPICARDIAN study

Blanco, Francisco J.; Gil, Paloma; Arco, Carmen del; Sáez, Teresa; Aguilar, Río; Lara, I.; Cruz, Juan; Gabriel, Rafael; Suárez, C.

doi:10.1097/01.mbp.0000218010.11323.b3

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…The methods of OBP and awake ABP measurements in the selected studies are shown in Supplemental Table 1 (S1). In the meta-analysis of the 23 studies of adults (N=10249) 7,15,16,20–25,28,29,31–38,40–42,44 , office systolic/diastolic BP [mean (95 % confidence intervals)] was 1.8 (1.8–1.9)/1.9 (1.8–2.0) mmHg higher than awake ABP (both P<0.001), but in the parallel analysis of the 5 studies of children and youth (N=1829) 26,27,30,39,43 , awake ABP was 8.4 (8.2–8.5)/7.0 (6.9–7.1) mmHg higher than office BP (both P<0.001).…”

Section: Resultsmentioning

confidence: 99%

Age and the difference between awake ambulatory blood pressure and office blood pressure

Ishikawa

Edmondson

et al. 2011

Blood Pressure Monitoring

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Background Ambulatory blood pressure (ABP) is a better predictor of adverse cardiovascular events than office BP (OBP). Due to the extensive literature on the “white coat effect”, it is widely believed that ABP tends to be lower than OBP, with statements to this effect in JNC VII. However, recent evidence suggests that the difference varies systematically with age. Methods We searched PubMed to identify population studies, published before April 2009, which assessed office BP and either ABP or home BP. Because of significant heterogeneity in the outcomes, random effects models were used for the meta-analyses. Results OBP increased with age more steeply than awake ABP. OBP became higher than awake systolic/diastolic ABP at the age of 51.3/42.7 years in men (13 studies, N=3562) and 51.9/42.3 years in women (11 studies, N=2585). In the data in which OBP and HBP were measured (8 studies, N=4916), OBP was higher than HBP at all ages. In the data in which OBP, awake ABP and HBP were all measured (2 studies, N=895), awake ABP was higher than HBP at younger ages, becoming similar at the older age. Conclusion OBP tends to be higher than awake ABP only after age 50 for systolic and age 45 for diastolic, but is lower than ABP at younger ages; in contrast OBP tends to exceed HBP at all ages.

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Section: Resultsmentioning

confidence: 99%

Age and the difference between awake ambulatory blood pressure and office blood pressure

Ishikawa

Edmondson

et al. 2011

Blood Pressure Monitoring

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“…29,30 Nocturnal hypertension with respect to the nondipping pattern more frequently determines impaired vascular function underlining the importance of the magnitude of BP levels on the progression of atherosclerotic damage. 24,31,32 In the same lines, nocturnal BP contributes to the progression of vascular damage even below the threshold of nocturnal hypertension (that is, o125/75 mm Hg); by contrast, the nondipping pattern is less frequently associated with vascular damage. These findings from cross-sectional observational studies highlight the detrimental role of the magnitude of nighttime haemodynamics on vascular function, suggesting a lower threshold of nighttime BP that triggers vascular impairment.…”

Section: Vascular and Cerebral Adaptationsmentioning

confidence: 99%

Increased nighttime blood pressure or nondipping profile for prediction of cardiovascular outcomes

et al. 2010

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At present, clinic blood pressure (BP) evaluation is being increasingly complemented by ambulatory BP measurements for the evaluation of haemodynamic patterns during daily activities and sleep. Nondipping pattern, a measure of decreased attenuation of nighttime over daytime BP, has been correlated with enhanced target organ damage and adverse cardiovascular (CV) outcomes in different clinical settings beyond pure hypertensive cohorts. As the nondipping pattern is a derivative extract of both daytime and nighttime BP, it is yet questionable whether the crude estimate of nocturnal BP is superior to daytime BP and nondipping pattern in the prediction of subclinical damage and CV events. In this review, we aimed at comparing the CV predictive value of the nondipping pattern with that of nocturnal BP using cross-sectional and longitudinal data obtained from different cohort studies within the past 10 years. Our findings suggest that nocturnal BP including the phenotype of isolated nocturnal hypertension is better associated with CV target organ damage and 'hard end points' as compared with the nondipping pattern.

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“…Furthermore, sympathetic hyperactivity and specifiAvailable online 18 January 2013 cally elevated norepinephrine levels have been identified as possible promoting factors of structural vascular disease development and progression [9,10]. It is therefore conceivable that individuals with nocturnal hypertension may have a higher prevalence of subclinical atherosclerosis [11]. Elevated nocturnal blood pressure may, therefore, be a significant cardiovascular health threat.…”

Section: Introductionmentioning

confidence: 99%

Nocturnal Blood Pressure, 3-Methoxy-4-hydroxyphenylglycol and Carotid Intima-media Thickness: The SABPA Study

Uys

Malan

Rooyen

et al. 2013

Heart, Lung and Circulation

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Association of clinic and ambulatory blood pressure with vascular damage in the elderly: the EPICARDIAN study

Cited by 10 publications

References 44 publications

Age and the difference between awake ambulatory blood pressure and office blood pressure

Age and the difference between awake ambulatory blood pressure and office blood pressure

Increased nighttime blood pressure or nondipping profile for prediction of cardiovascular outcomes

Nocturnal Blood Pressure, 3-Methoxy-4-hydroxyphenylglycol and Carotid Intima-media Thickness: The SABPA Study

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