Association of clinical and laboratory variables with in-hospital incidence of deep vein thrombosis in patients after acute ischemic stroke

Abstract

Deep vein thrombosis (DVT) is a serious complication in patients with acute ischemic stroke (AIS). Early prediction of DVT could enable physicians to perform a proper prevention strategy. We analyzed the association of clinical and laboratory variables with DVT to evaluate the risk of DVT in patients after AIS. AIS patients admitted to the Changsha Central Hospital between January 2017 and December 2019 with length of stay in hospital ≥7 days were included. Clinical and laboratory variables for DVT at baseline were collected, and the diagnosis of DVT was confirmed by ultrasonography. Independent factors were developed by Multivariate logistic regression analysis. A total of 101 patients were included in the study. The in-hospital incidence of DVT after AIS was 19.8%(20/101). The average level of D-dimer when DVT detected was significant increased around 4-fold than that on admission ( P < .001). Pulmonary infection (odds ratio [OR] = 5.4, 95%CI:1.10–26.65, P = .037)) and increased muscle tone (OR = 0.11, 95%CI:0.02–0.58, P = .010) as independent relevant factors for DVT were confirmed. Pulmonary infection as a risk factor and increased muscle tone as a protective factor for DVT were identified in patients after AIS. The level of D-dimer which increased around 4-fold compared to the initial level could be an indicator for DVT occurrence.

Functional status and its related factors among stroke survivors in rehabilitation departments of hospitals in Shenzhen, China: a cross-sectional study

“…This is because infections could lead to immobilization, general frailty and rehabilitation delay which affect stroke survivors' functional outcomes [ 13 , 49 ]. Pulmonary infections can also contribute to other complications such as DVT [ 12 ].…”

“…Some complications are also considered essential factors that affect the rehabilitation outcomes of stroke survivors [ 12 – 14 ]. Pulmonary infection, deep vein thrombosis (DVT), and urinary tract infection are the common complications after stroke [ 1 , 14 , 15 ].…”

“…Moreover, these complications influence one another, and the presence of one of these complications increases the likelihood of other complications. In addition, pulmonary infection is an independent risk factor associated with DVT in hospitalized patients with stroke [ 12 ]. Even though functional outcome studies among stroke survivors, in general, have shown that the strongest predictor of functional recovery is the initial severity of the stroke [ 16 , 17 ], few studies have detailed the clinical characteristics of hospitalized patients with stroke [ 17 ], especially in rehabilitation departments of urban hospitals in China, as approximately 1115 cases per 100 000 people has experienced a stroke in their lifetime [ 18 ].…”

Functional Status and Its Related Factors Among Stroke Survivors in Rehabilitation Departments of Hospitals in Shenzhen, China

“…The presence of chronic disease and demographic factors such as age, sex, complications, and lifestyle behaviors (e.g., smoking or use of alcohol) play an important role in the development of functional outcomes of patients with stroke [1,11,[17][18][19]. Pulmonary infection, deep vein thrombosis (DVT), urinary tract infection are the common complications after stroke [1].…”

“…Moreover, these complications in uence each other and are risk factors for each other. Pulmonary infection is an independent risk factor associated with DVT in hospitalized patients with stroke [17]. Even though functional outcome studies among stroke survivors, in general, have shown that the most powerful predictor of functional recovery is the initial severity of the stroke [22,23], but few studies detailed the clinical characteristics of hospitalized patients with stroke [23], especially in rehabilitation departments of urban hospitals in China.…”