Association of clinical outcomes and the predictive value of T lymphocyte subsets within colorectal cancer patients

Yuan, Chaofeng; Huang, Jiannan; Li, Haitao; Zhai, Rongnan; Zhai, Jin; Fang, Xuedong; Wu, Yue

doi:10.3389/fsurg.2023.1102545

Cited by 3 publications

(5 citation statements)

References 25 publications

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“…The immune ability of the patients directly affects the development of tumors, and T lymphocytes play an indispensable role in the fight against tumors. CD4 + T lymphocytes can activate CD8 + T lymphocytes through a variety of pathways to kill tumor cells, and CD3 + -induced lymphocyte proliferation plays a central role in the immune response cascade (McGregor et al, 2004;Yuan et al, 2023). One study showed that Frontiers in Pharmacology frontiersin.org higher levels of CD3 + , CD4 + , and CD8 + were associated with longer survival (Castaneda et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of traditional Chinese medicine on postoperative depression of breast cancer: a systematic review and meta-analysis

et al. 2023

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Background: Depression is one of the common complications in patients with postoperative breast cancer (BC). Conventional therapies for postoperative depression of BC always have modest treatment outcomes and undesirable side effects. Clinical practice and many studies have shown that traditional Chinese medicine (TCM) has a good effect on postoperative depression of BC. This meta-analysis aimed to assess the clinical effect of TCM as an add-on treatment for postoperative depression of BC.Methods: A systematic and thorough search was conducted on eight online electronic databases up to 20 July 2022. The control group received conventional therapies, and intervention groups received what control groups received plus TCM treatment. Review Manager 5.4.1 was used for statistical analysis.Results: Nine RCTs involved 789 participants who met the inclusion standards. The results showed the intervention group was better at decreasing the score of the Hamilton rating scale for depression (HAMD) (mean difference, MD = −4.21, 95% CI −5.54 to −2.88) and the self-rating depression scale (SDS) (MD = −12.03, 95% CI −15.94 to −8.13), improving clinical efficacy (RR = 1.25, 95% CI 1.14–1.37), increasing the levels of 5-hydroxytryptamine (5-HT) (MD = 0.27, 95% CI 0.20–0.34), dopamine (DA) (MD = 26.28, 95% CI 24.18–28.77), and norepinephrine (NE) (MD = 11.05, 95% CI 8.07–14.04), and influencing the immune index, including the levels of CD3+ (MD = 15.18, 95% CI 13.61–16.75), CD4+ (MD = 8.37, 95% CI 6.00–10.74), and CD4+/CD8+ (MD = 0.33, 95% CI 0.27–0.39). The level of CD8+ (MD = −4.04, 95% CI −11.98 to 3.99) had no obvious difference between the two groups.Conclusion: The meta‐analysis stated that a therapeutic regimen involving TCM could better improve the depression status in postoperative BC.

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Section: Discussionmentioning

confidence: 99%

Effect of traditional Chinese medicine on postoperative depression of breast cancer: a systematic review and meta-analysis

et al. 2023

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“…The correlation analysis performed in the present study indicated that there is a negative relationship between the levels of CEA and TK1 and the CD3 + T, CD4 + T, and CD8 + T lymphocyte counts. On the other hand, Yuan et al [13] suggested that CD8 + T lymphocytes exhibited a positive correlation with CEA. The differences in conclusions may be attributed to the characteristics of the subjects and the sample sizes involved.…”

Section: Discussionmentioning

confidence: 99%

“…Low and high expression of Ki-67 was defined as positive staining for Ki-67 ≤ 60% and Ki-67 > 60%, respectively. [13,14]…”

Section: Methodsmentioning

confidence: 99%

“…[12] However, limited research has been conducted on the correlation between T lymphocyte subsets and clinical features in the context of CRC. To the best of our knowledge, the only study on this topic was conducted by Yuan et al, [13] who examined the correlation between the percentage of cells in each subgroup and the clinical characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Association of T lymphocyte subset counts with the clinical features of colorectal cancer

Zhang,

Shi,

Yang

et al. 2023

J Nutr Oncol

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Background Colorectal cancer (CRC) is a common gastrointestinal malignancy. The T lymphocyte subsets are important in the development, invasion and metastasis of tumors, including CRC. Nevertheless, limited research has explored the relationship between T cell subpopulations and the clinical characteristics of CRC. This study compared the T lymphocyte subsets in patients with CRC and healthy individuals and assessed the relationship between these values and clinical characteristics. Methods Peripheral blood was collected from 100 patients with CRC and 54 healthy individuals. The numbers of CD3+ T, CD4+ T, and CD8+ T lymphocytes, natural killer (NK) cells, and the CD4+/CD8+, ratio in peripheral blood were measured using flow cytometry and were compared between CRC patients and healthy individuals. Spearman’s correlation analysis was performed to investigate the relationship between the T lymphocyte subsets in patients diagnosed with CRC and the levels of carcinoembryonic antigen (CEA) and thymidine kinase 1 (TK1). Receiver operating characteristic (ROC) curves were utilized to evaluate the potential utility of the T lymphocyte counts in predicting lymph node metastasis, vascular infiltration, and high Ki-67 expression. Results The CRC patients had lower counts of CD3+ T, CD4+ T, and CD8+ T lymphocytes compared to the healthy population (P < 0.05). However, no significant differences were observed in the CD4+/CD8+ ratio or NK cells (P > 0.05). Notably, the CD3+ T, CD4+ T, and CD8+ T lymphocyte counts were higher in patients with stage I-II disease, no lymph node metastasis, no vascular invasion, and low Ki-67 expression than in those with stage III, lymph node metastasis, vascular invasion, and high Ki-67 expression (P < 0.05). There was a negative association between the CD3+ T, CD4+ T, and CD8+ T lymphocyte counts and CEA and TK1 levels in patients with CRC. The ROC curves demonstrated that CD3+ T, CD4+ T, and CD8+ T lymphocyte counts had significant predictive value for lymph node metastasis, vascular infiltration, and high Ki-67 expression. Conclusions The peripheral blood CD3+ T, CD4+ T, and CD8+ T lymphocyte counts are related to the clinical traits of patients with CRC and can predict the prognosis of the disease.

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“…Previous studies have shown an association between the densities of CD8+ T lymphocytes in the peripheral blood and the prognosis of various types of cancers, including non-small cell lung, breast, colorectal, pancreatic and bladder cancers [10][11][12][13][14]. In prostate cancer (PCa), most studies have focused on the associations between intratumoral T lymphocyte subpopulations and clinical outcomes [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

Baxevanis

Stokidis

Goulielmaki

et al. 2023

Onco

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Background: Various studies have reported associations between frequencies of total peripheral blood lymphocytes and prostate cancer prognosis, but none so far has addressed the prognostic role of CD8+ T-lymphocyte subsets. Methods: A total of 43 prostate cancer patients with metastatic disease and 81 patients with non-metastatic disease were included in this study. Flow cytometry analyses were employed for determining the frequencies of peripheral CD8+ T-lymphocyte subsets. Results: Statistically significant lower levels of terminally differentiated effector (TEMRA) cells in patients with non-metastatic disease vs. patients with metastatic disease were observed. Central memory (CM) and effector memory (EM) CD8+ subsets, were found to be significantly higher in patients with non-metastatic disease vs. patients with metastatic disease. A similar profile was revealed when these CD8+ subsets were analyzed based on the patients’ Gleason scores, as well as by combined disease stage (i.e., non-metastatic vs. metastatic disease) and Gleason score. Conclusions: Peripheral blood-derived CD8+ T-lymphocyte memory subsets could function as biomarkers for the prognosis of PCa.

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Association of clinical outcomes and the predictive value of T lymphocyte subsets within colorectal cancer patients

Cited by 3 publications

References 25 publications

Effect of traditional Chinese medicine on postoperative depression of breast cancer: a systematic review and meta-analysis

Effect of traditional Chinese medicine on postoperative depression of breast cancer: a systematic review and meta-analysis

Association of T lymphocyte subset counts with the clinical features of colorectal cancer

Peripheral Blood CD8+ T-Lymphocyte Subsets Are Associated with Prognosis in Prostate Cancer Patients

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