Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes

Hayashi, Kumi; Kurioka, Soichi; Yamaguchi, Toru; Morita, Miwa; Kanazawa, Ippei; Takase, Hirofumi; Wada, Akihiko; Kitagaki, Hajime; Nagai, Atsushi; Bokura, Hirokazu; Yamaguchi, Shûhei; Sugimoto, Toshitsugu

doi:10.1016/j.diabres.2011.07.002

Cited by 73 publications

(53 citation statements)

References 23 publications

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“…These results are consistent with those reported in other studies performed in subjects with T2D (12,13).…”

Section: Discussionsupporting

confidence: 83%

“…Apparently, various brain areas are involved in the visuospatial/ executive and delayed recall functions as assessed in the MoCA test (fronto-parieto-occipital cortices for the visuospatial/ executive function and hippocampal-parieto-frontal areas for retrieval memory, respectively) (21). Neuroimaging studies have shown that patients with T2D have global brain atrophy, but also regional atrophy in the hippocampus and prefrontal regions, which may explain at least in part the cognitive deficits seen in these patients (9,13). In fact, there is some evidence that higher blood glucose levels, even in the normal range, are associated with atrophy in the hippocampus and amygdala, brain regions critically important for memory (22).…”

Section: Discussionmentioning

confidence: 99%

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Markers of cognitive impairment in patients with type 2 diabetes

Șular¹,

Huţanu²,

Voidăzan³

2016

Revista Romana De Medicina De Laborator

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Background. The study aimed to evaluate the correlations of cognitive function with metabolic, nutritional, hormonal and immunologic parameters in patients with type 2 diabetes (T2D), in order to identify markers of cognitive impairment. Material and methods. This cross-sectional study included 216 T2D patients and 23 healthy individuals (HC p: 0.004). T2D patients with cognitive dysfunction were significantly older and less formally educated (p < 0.0001). Age negatively correlated with MoCA scores p < 0.0001). T2D patients had significantly lower p < 0.0001). Serum Mg levels positively correlated with MoCA scores (0.24, 95%CI: 0.07, 0.39; p: 0.003) and with visuospatial/executive (0.30; 95%CI: 0.14, 0.45; p: 0.0002) and naming functions (0.18; 95%CI: 0.01, 0.34; p: 0.02

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“…These results are consistent with those reported in other studies performed in subjects with T2D (12,13).…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Markers of cognitive impairment in patients with type 2 diabetes

Șular¹,

Huţanu²,

Voidăzan³

2016

Revista Romana De Medicina De Laborator

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“…Inversion prepulses were applied to suppress the signal contamination of cerebrospinal fluid (15). Images were acquired at multiple b values (0, 5,7,10,15,20,30,40,50,60,100,200, 400, 700, 1,000, and 1,500 s/mm 2 ) in the phaseencoding direction, and the number of signal averages was 1, except for the largest three b values, which were 2, 3, and 3, respectively, to improve the signal-to-noise ratio.…”

Section: Study Populationmentioning

confidence: 99%

On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes

et al. 2015

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OBJECTIVEType 2 diabetes is associated with accelerated cognitive decline, especially regarding memory for which the hippocampus plays an essential role. The pathophysiological mechanisms still remain to be elucidated. The purpose of this study is to examine whether hippocampal microvascular and microstructural changes are related to type 2 diabetes (based on status or based on fasting blood glucose [FBG] levels) and verbal memory performance. RESEARCH DESIGN AND METHODSThirty-nine participants with type 2 diabetes (64.5 6 6.1 years old) and 34 participants without type 2 diabetes (58.3 6 9.2 years old) underwent detailed cognitive assessments and 3-Tesla MRI using intravoxel incoherent motion (IVIM) MRI. Multivariate regression analyses controlling for age, sex, education level, BMI, systolic blood pressure, hematocrit level, and relative hippocampal volume were performed to examine associations between hippocampal IVIM measures, type 2 diabetes (status and FBG), and memory performance. RESULTSFor the microvasculature, blood perfusion volume (f) was larger in participants with type 2 diabetes, f and blood flow (fD*) increased with higher FBG levels, and microvascular pseudodiffusion (D*) and fD*, which are indicative of altered microvasculature, were higher in participants with both relatively high FBG levels and low memory performance. In addition, fD* increased with lower memory performance. For the parenchymal microstructure, the diffusion (D), indicative of injured microstructure, was higher with reduced memory performance. CONCLUSIONSIn addition to the parenchymal microstructure, especially the microvascular properties of the hippocampus are altered in participants with both type 2 diabetes and memory problems and possibly hint at an underlying vascular mechanism.Type 2 diabetes is associated with cognitive deficits, accelerated cognitive decline, and an increased risk of dementia and Alzheimer disease (AD) (1-3). A prominently affected cognitive domain in type 2 diabetes is memory (4), for which the hippocampus plays an essential role. In patients with type 2 diabetes and memory problems, reduced hippocampal volumes have previously been reported (5). Furthermore, chronic hyperglycemia has been shown to be associated with altered hippocampal microstructure and memory performance in elderly individuals without diabetes (6). Unfortunately, the exact mechanism underlying hyperglycemia and

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“…[16][17][18][19] A continuación se describirán los principales cambios neuroanatómicos que se presentan en la DM2, así como la repercusión que dichos cambios tienen en el funcionamiento cognoscitivo y la asociación que éste tiene con los factores relacionados con la adherencia terapéutica.…”

Section: -15unclassified

Funcionamiento cognoscitivo en la diabetes tipo 2: una revisión

et al. 2013

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El objetivo de este trabajo es ofrecer una revisión actualizada de las principales dificultades cognoscitivas que se presentan en la Diabetes mellitus tipo 2 (DM2) y su asociación con factores relacionados con la adherencia terapéutica propuestos por la Organización Panamericana de la Salud para las enfermedades crónicas como: las características del paciente, de la enfermedad y del tratamiento. La revisión se basó en una búsqueda en las bases de datos PubMed, PsycINFO y SpringerLink. Se abarcó el periodo de enero de 2000 hasta diciembre de 2011, y predominaron las investigaciones procedentes de los Estados Unidos de América, Canadá, Holanda, Inglaterra, el Japón, México y Alemania. En la mayoría de los estudios consultados se identificó que las fluctuaciones glicémicas, la duración de la enfermedad y el tipo de tratamiento farmacológico son los factores que más se han asociado con el funcionamiento cognoscitivo en la DM2. En cuanto a los cambios que se producen en el Sistema Nervioso Central (SNC), hasta la fecha no hay consenso en cuanto a si estos son exclusivamente degenerativos, vasculares o si son una combinación entre ambos. En el aspecto cognoscitivo, se ha reportado que la DM2 es un factor de riesgo para desarrollar deterioro cognoscitivo leve y que la cronicidad de esta condición, asociada a hipertensión, a un control glicémico inadecuado y a complicaciones macrovasculares aumenta la posibilidad de desarrollar demencia vascular. Las habilidades cognoscitivas más referidas como afectadas son memoria verbal y de trabajo, fluidez verbal, atención, planificación mental y velocidad psicomotora, las cuales se han relacionado con el funcionamiento de estructuras frontales, temporales e hipocámpicas, que en la DM2 también se encuentran comprometidas. Se concluye que a pesar de que se han identificado algunos factores de riesgo de las deficiencias cognoscitivas en la DM2, es importante que se determine cómo interactúan y en qué grado influyen estos factores en el rendimiento cognoscitivo global y en funciones específicas en esta población.

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Association of cognitive dysfunction with hippocampal atrophy in elderly Japanese people with type 2 diabetes

Cited by 73 publications

References 23 publications

Markers of cognitive impairment in patients with type 2 diabetes

Markers of cognitive impairment in patients with type 2 diabetes

On the Interplay of Microvasculature, Parenchyma, and Memory in Type 2 Diabetes

Funcionamiento cognoscitivo en la diabetes tipo 2: una revisión

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